Natural products with 1,2-oxazine scaffold: occurrence, chemical diversity, bioactivity, synthesis, and biosynthesis
2
Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Wenhai Road 1, Qingdao 266237, China
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4
Center for Ocean Mega-Science, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China
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Publication type: Journal Article
Publication date: 2023-08-29
scimago Q1
wos Q1
SJR: 2.463
CiteScore: 22.8
Impact factor: 10.6
ISSN: 02650568, 14604752
PubMed ID:
37642299
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
Covering: up to the end of July, 2023
1,2-Oxazine is a heterocyclic scaffold rarely found in natural products and is characterized by a directly connected N–O bond in a six-membered ring. Since the discovery of geneserine, the first 1,2-oxazine-containing natural product (1,2-oxazine NP) being isolated from Calabar bean (Physostigma venenosum) in 1925, a total of 76 naturally occurring 1,2-oxazine NPs have been isolated and identified from various sources, which have attracted the attention of researchers in the field of natural product chemistry, organic synthesis, biosynthesis, and pharmacology. This review summarizes the chemical family of 1,2-oxazine NPs, focusing on their source organisms, structural diversities, chemical synthesis, and biosynthesis.
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18
Total citations:
18
Citations from 2024:
16
(88.88%)
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GOST
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Yan L. et al. Natural products with 1,2-oxazine scaffold: occurrence, chemical diversity, bioactivity, synthesis, and biosynthesis // Natural Product Reports. 2023. Vol. 40. No. 12. pp. 1874-1900.
GOST all authors (up to 50)
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Yan L., Li X., Wang B. Natural products with 1,2-oxazine scaffold: occurrence, chemical diversity, bioactivity, synthesis, and biosynthesis // Natural Product Reports. 2023. Vol. 40. No. 12. pp. 1874-1900.
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RIS
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TY - JOUR
DO - 10.1039/d3np00023k
UR - https://xlink.rsc.org/?DOI=D3NP00023K
TI - Natural products with 1,2-oxazine scaffold: occurrence, chemical diversity, bioactivity, synthesis, and biosynthesis
T2 - Natural Product Reports
AU - Yan, Li-Hong
AU - Li, Xin
AU - Wang, Bingui
PY - 2023
DA - 2023/08/29
PB - Royal Society of Chemistry (RSC)
SP - 1874-1900
IS - 12
VL - 40
PMID - 37642299
SN - 0265-0568
SN - 1460-4752
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2023_Yan,
author = {Li-Hong Yan and Xin Li and Bingui Wang},
title = {Natural products with 1,2-oxazine scaffold: occurrence, chemical diversity, bioactivity, synthesis, and biosynthesis},
journal = {Natural Product Reports},
year = {2023},
volume = {40},
publisher = {Royal Society of Chemistry (RSC)},
month = {aug},
url = {https://xlink.rsc.org/?DOI=D3NP00023K},
number = {12},
pages = {1874--1900},
doi = {10.1039/d3np00023k}
}
Cite this
MLA
Copy
Yan, Li-Hong, et al. “Natural products with 1,2-oxazine scaffold: occurrence, chemical diversity, bioactivity, synthesis, and biosynthesis.” Natural Product Reports, vol. 40, no. 12, Aug. 2023, pp. 1874-1900. https://xlink.rsc.org/?DOI=D3NP00023K.