Disclosing biosynthetic connections and functions of atypical angucyclinones with a fragmented C-ring
Publication type: Journal Article
Publication date: 2021-01-22
scimago Q1
wos Q1
SJR: 2.463
CiteScore: 22.8
Impact factor: 10.6
ISSN: 02650568, 14604752
PubMed ID:
33480893
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
This review on atypical angucyclinones possessing an aromatic cleavage of the C-ring covers literature between 1995 and early 2020.
The unusual framework of the middle C-ring, “broken” as a result of biotransformations and oxidations in vivo and bearing an sp3-C connection, is of interest for biosynthetic investigations. The reported 39 natural compounds (55 including stereoisomers) have been analyzed and arranged into three structural groups. The biosynthetic origin of all these compounds has been thoroughly reviewed and revised, based on the found connections with oxidized angucyclinone structures. The data on biological activities has been summarized. Careful consideration of the origin of the structure allowed us to outline a hypothesis on the biological function as well as prospective applications of such atypical angucyclinones.
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21
Total citations:
21
Citations from 2024:
9
(45%)
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GOST
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Mikhaylov A. A. et al. Disclosing biosynthetic connections and functions of atypical angucyclinones with a fragmented C-ring // Natural Product Reports. 2021. Vol. 38. No. 8. pp. 1506-1517.
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Mikhaylov A. A., Ikonnikova V. A., Solyev P. N. Disclosing biosynthetic connections and functions of atypical angucyclinones with a fragmented C-ring // Natural Product Reports. 2021. Vol. 38. No. 8. pp. 1506-1517.
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RIS
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TY - JOUR
DO - 10.1039/D0NP00082E
UR - https://xlink.rsc.org/?DOI=D0NP00082E
TI - Disclosing biosynthetic connections and functions of atypical angucyclinones with a fragmented C-ring
T2 - Natural Product Reports
AU - Mikhaylov, Andrey A
AU - Ikonnikova, Viktoria A
AU - Solyev, Pavel N.
PY - 2021
DA - 2021/01/22
PB - Royal Society of Chemistry (RSC)
SP - 1506-1517
IS - 8
VL - 38
PMID - 33480893
SN - 0265-0568
SN - 1460-4752
ER -
Cite this
BibTex (up to 50 authors)
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@article{2021_Mikhaylov,
author = {Andrey A Mikhaylov and Viktoria A Ikonnikova and Pavel N. Solyev},
title = {Disclosing biosynthetic connections and functions of atypical angucyclinones with a fragmented C-ring},
journal = {Natural Product Reports},
year = {2021},
volume = {38},
publisher = {Royal Society of Chemistry (RSC)},
month = {jan},
url = {https://xlink.rsc.org/?DOI=D0NP00082E},
number = {8},
pages = {1506--1517},
doi = {10.1039/D0NP00082E}
}
Cite this
MLA
Copy
Mikhaylov, Andrey A., et al. “Disclosing biosynthetic connections and functions of atypical angucyclinones with a fragmented C-ring.” Natural Product Reports, vol. 38, no. 8, Jan. 2021, pp. 1506-1517. https://xlink.rsc.org/?DOI=D0NP00082E.