Approach to tune drug release in particles fabricated from methacrylate functionalized polylactides
Boris S. Shavkuta
1, 2
,
Boris Shavkuta
3, 4, 5, 6, 7
,
Kseniia N. Bardakova
1, 3, 4, 5, 6, 8, 9
,
Yana Khristidis
1, 2, 3, 4, 5, 6, 7
,
N. V. Minaev
8
,
Nikita V Minaev
5, 6, 9, 10
,
Anastasia Frolova
3, 4, 5, 6
,
Svetlana L Kotova
1, 3, 4, 5, 6, 11, 12
,
N A Aksenova
1, 11
,
Nadezhda Aksenova
3, 4, 5, 6, 12
,
Zahra Heydari
13, 14, 15, 16, 17, 18
,
Semenova Elena
6, 19, 20, 21, 22
,
Tatyana Khlebnikova
1, 3, 4, 5, 6, 23, 24
,
Elena N Golubeva
25
,
Sergei V. Kostjuk
1, 26, 27
,
Sergei Kostjuk
3, 4, 5, 6, 28
,
Massoud Vosough
13
,
Petr S. Timashev
1, 2, 3, 4, 5, 6, 7, 8, 11, 25
,
Anastasia I. Shpichka
1, 2, 3, 4, 5, 6, 7
3
Institute for Regenerative Medicine
5
Moscow
6
Russia
|
7
World-Class Research Center "Digital biodesign and personalized healthcare"
8
11
12
Department of Polymers and Composites
13
14
Department of Regenerative Medicine
15
Cell Science Research Center
18
Tehran
|
20
Institute for City Development
22
Sevastopol
|
24
Institute for Uronephrology and Reproductive Health
26
Publication type: Journal Article
Publication date: 2021-01-13
scimago Q1
wos Q3
SJR: 0.744
CiteScore: 5.6
Impact factor: 3.2
ISSN: 20589689
Materials Chemistry
Chemistry (miscellaneous)
Process Chemistry and Technology
Industrial and Manufacturing Engineering
Energy Engineering and Power Technology
Biomedical Engineering
Chemical Engineering (miscellaneous)
Abstract
The development of thermolabile substance carriers with a variable shape, size, and release kinetics is one of the most difficult goals of the pharmaceutical industry. Here, we propose to use the two-step combination of two-photon polymerization (2PP) and micromolding techniques to fabricate particles of a preset shape and size from star-shaped methacrylate functionalized poly(D,L)-lactides. Using a 2PP set-up, we fabricated an E-Shell cube-patterned matrix used to prepare a silicon mold. Then this mold was filled with functionalized poly(D,L)-lactides mixed with 4,4′-bis(dimethylamino)benzophenone as a photoinitiator and exposed to UV irradiation to crosslink particles which were further easily detached. The study revealed that the arm length of the functionalized polylactides caused differences in the mechanical properties and surface topography of the fabricated particles that determined their degradation rate, drug loading and release. Using the arm length as a structure parameter, one can prepare tailored polylactide particles with controllable substance release.
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Total citations:
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Citations from 2024:
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(57%)
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GOST
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Shavkuta B. S. et al. Approach to tune drug release in particles fabricated from methacrylate functionalized polylactides // Molecular Systems Design and Engineering. 2021. Vol. 6. No. 3. pp. 202-213.
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Shavkuta B. S. et al. Approach to tune drug release in particles fabricated from methacrylate functionalized polylactides // Molecular Systems Design and Engineering. 2021. Vol. 6. No. 3. pp. 202-213.
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RIS
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TY - JOUR
DO - 10.1039/d0me00157k
UR - https://xlink.rsc.org/?DOI=D0ME00157K
TI - Approach to tune drug release in particles fabricated from methacrylate functionalized polylactides
T2 - Molecular Systems Design and Engineering
AU - Shavkuta, Boris S.
AU - Shavkuta, Boris
AU - Bardakova, Kseniia N.
AU - Khristidis, Yana
AU - Minaev, N. V.
AU - Minaev, Nikita V
AU - Frolova, Anastasia A
AU - Frolova, Anastasia
AU - Kotova, Svetlana L
AU - Aksenova, N A
AU - Aksenova, Nadezhda
AU - Heydari, Zahra
AU - Elena, Semenova
AU - Khlebnikova, Tatyana
AU - Golubeva, Elena N
AU - Kostjuk, Sergei V.
AU - Kostjuk, Sergei
AU - Vosough, Massoud
AU - Timashev, Petr S.
AU - Shpichka, Anastasia I.
PY - 2021
DA - 2021/01/13
PB - Royal Society of Chemistry (RSC)
SP - 202-213
IS - 3
VL - 6
SN - 2058-9689
ER -
Cite this
BibTex (up to 50 authors)
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@article{2021_Shavkuta,
author = {Boris S. Shavkuta and Boris Shavkuta and Kseniia N. Bardakova and Yana Khristidis and N. V. Minaev and Nikita V Minaev and Anastasia A Frolova and Anastasia Frolova and Svetlana L Kotova and N A Aksenova and Nadezhda Aksenova and Zahra Heydari and Semenova Elena and Tatyana Khlebnikova and Elena N Golubeva and Sergei V. Kostjuk and Sergei Kostjuk and Massoud Vosough and Petr S. Timashev and Anastasia I. Shpichka and others},
title = {Approach to tune drug release in particles fabricated from methacrylate functionalized polylactides},
journal = {Molecular Systems Design and Engineering},
year = {2021},
volume = {6},
publisher = {Royal Society of Chemistry (RSC)},
month = {jan},
url = {https://xlink.rsc.org/?DOI=D0ME00157K},
number = {3},
pages = {202--213},
doi = {10.1039/d0me00157k}
}
Cite this
MLA
Copy
Shavkuta, Boris S., et al. “Approach to tune drug release in particles fabricated from methacrylate functionalized polylactides.” Molecular Systems Design and Engineering, vol. 6, no. 3, Jan. 2021, pp. 202-213. https://xlink.rsc.org/?DOI=D0ME00157K.