Molecular Systems Design and Engineering, volume 6, issue 3, pages 202-213
Approach to tune drug release in particles fabricated from methacrylate functionalized polylactides
Shavkuta Boris S.
1, 2
,
Bardakova Kseniia N.
1, 3
,
Khristidis Yana
1, 2
,
Minaev N. V.
3
,
Frolova Anastasia A
1
,
Kotova Svetlana L
1, 4
,
Aksenova N A
1, 4
,
Heydari Zahra
5
,
Elena Semenova
6
,
Khlebnikova Tatyana
1, 7
,
Golubeva Elena N
8
,
Kostjuk Sergei V.
1, 9, 10
,
Vosough Massoud
5
,
Timashev Petr S.
1, 2, 3, 4, 8
,
3
4
5
Publication type: Journal Article
Publication date: 2021-01-13
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 3.6
ISSN: 20589689
Materials Chemistry
Chemistry (miscellaneous)
Process Chemistry and Technology
Industrial and Manufacturing Engineering
Energy Engineering and Power Technology
Biomedical Engineering
Chemical Engineering (miscellaneous)
Abstract
The development of thermolabile substance carriers with a variable shape, size, and release kinetics is one of the most difficult goals of the pharmaceutical industry. Here, we propose to use the two-step combination of two-photon polymerization (2PP) and micromolding techniques to fabricate particles of a preset shape and size from star-shaped methacrylate functionalized poly(D,L)-lactides. Using a 2PP set-up, we fabricated an E-Shell cube-patterned matrix used to prepare a silicon mold. Then this mold was filled with functionalized poly(D,L)-lactides mixed with 4,4′-bis(dimethylamino)benzophenone as a photoinitiator and exposed to UV irradiation to crosslink particles which were further easily detached. The study revealed that the arm length of the functionalized polylactides caused differences in the mechanical properties and surface topography of the fabricated particles that determined their degradation rate, drug loading and release. Using the arm length as a structure parameter, one can prepare tailored polylactide particles with controllable substance release.
Citations by journals
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1
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Polymers
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Polymers
1 publication, 25%
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Advanced Drug Delivery Reviews
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Advanced Drug Delivery Reviews
1 publication, 25%
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Physics of Wave Phenomena
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Physics of Wave Phenomena
1 publication, 25%
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ACS Biomaterials Science and Engineering
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ACS Biomaterials Science and Engineering
1 publication, 25%
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1
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Citations by publishers
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1
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 25%
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Elsevier
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Elsevier
1 publication, 25%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 25%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
1 publication, 25%
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1
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Shavkuta B. S. et al. Approach to tune drug release in particles fabricated from methacrylate functionalized polylactides // Molecular Systems Design and Engineering. 2021. Vol. 6. No. 3. pp. 202-213.
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Shavkuta B. S., Bardakova K. N., Khristidis Y., Minaev N. V., Frolova A. A., Kotova S. L., Aksenova N. A., Heydari Z., Elena S., Khlebnikova T., Golubeva E. N., Kostjuk S. V., Vosough M., Timashev P. S., Shpichka A. I. Approach to tune drug release in particles fabricated from methacrylate functionalized polylactides // Molecular Systems Design and Engineering. 2021. Vol. 6. No. 3. pp. 202-213.
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TY - JOUR
DO - 10.1039/d0me00157k
UR - https://doi.org/10.1039%2Fd0me00157k
TI - Approach to tune drug release in particles fabricated from methacrylate functionalized polylactides
T2 - Molecular Systems Design and Engineering
AU - Bardakova, Kseniia N.
AU - Khristidis, Yana
AU - Kotova, Svetlana L
AU - Heydari, Zahra
AU - Khlebnikova, Tatyana
AU - Timashev, Petr S.
AU - Shpichka, Anastasia I.
AU - Elena, Semenova
AU - Shavkuta, Boris S.
AU - Minaev, N. V.
AU - Frolova, Anastasia A
AU - Aksenova, N A
AU - Golubeva, Elena N
AU - Kostjuk, Sergei V.
AU - Vosough, Massoud
PY - 2021
DA - 2021/01/13 00:00:00
PB - Royal Society of Chemistry (RSC)
SP - 202-213
IS - 3
VL - 6
SN - 2058-9689
ER -
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@article{2021_Shavkuta,
author = {Kseniia N. Bardakova and Yana Khristidis and Svetlana L Kotova and Zahra Heydari and Tatyana Khlebnikova and Petr S. Timashev and Anastasia I. Shpichka and Semenova Elena and Boris S. Shavkuta and N. V. Minaev and Anastasia A Frolova and N A Aksenova and Elena N Golubeva and Sergei V. Kostjuk and Massoud Vosough},
title = {Approach to tune drug release in particles fabricated from methacrylate functionalized polylactides},
journal = {Molecular Systems Design and Engineering},
year = {2021},
volume = {6},
publisher = {Royal Society of Chemistry (RSC)},
month = {jan},
url = {https://doi.org/10.1039%2Fd0me00157k},
number = {3},
pages = {202--213},
doi = {10.1039/d0me00157k}
}
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MLA
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Shavkuta, Boris S., et al. “Approach to tune drug release in particles fabricated from methacrylate functionalized polylactides.” Molecular Systems Design and Engineering, vol. 6, no. 3, Jan. 2021, pp. 202-213. https://doi.org/10.1039%2Fd0me00157k.