Synlett, volume 31, issue 11, pages 1067-1072
Straightforward Three-Component Synthesis of N′,N′′-Disubstituted N -Alkyl-1,3,5-Triazinanes
Frontera Antonio
2
,
Sinelshchikova Anna A
3
,
Grigoriev Mikhail S.
3
,
Grudova Mariya V
1
,
Shetnev Anton
5
,
2
Department of Chemistry, Universitat de les Illes Balears
Publication type: Journal Article
Publication date: 2020-04-17
Organic Chemistry
Abstract
Efficient approaches towards the synthesis of various N-substituted 1,3,5-triazinanes based on a transformation of N-alkyl-1,5,3-dioxazepanes or on a domino reaction involving condensation of various amines, amides, and paraformaldehyde are described for the first time. Mg(ClO4)2 was shown to be one of the most potent additives for the condensation. The proposed approaches permit the synthesis of a broad spectrum of substituted sym-triazinanes in good yields with relatively easy workup. In the case of the multicomponent reaction, the approach allows the preparation of the target substances from simple and easily accessible reagents. The representatives of the resulting compounds were found to possess no antimicrobial or cytotoxic activity in in vitro bioassays.
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1
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IOP Conference Series: Earth and Environmental Science
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1 publication, 16.67%
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Citations by publishers
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1
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Elsevier
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2 publications, 33.33%
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Multidisciplinary Digital Publishing Institute (MDPI)
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1 publication, 16.67%
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Springer Nature
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1 publication, 16.67%
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IOP Publishing
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IOP Publishing
1 publication, 16.67%
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Thieme
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Thieme
1 publication, 16.67%
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1
2
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Kletskov A. V. et al. Straightforward Three-Component Synthesis of N′,N′′-Disubstituted N -Alkyl-1,3,5-Triazinanes // Synlett. 2020. Vol. 31. No. 11. pp. 1067-1072.
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Kletskov A. V., Frontera A., Sinelshchikova A. A., Grigoriev M. S., Zaytsev V. P., Grudova M. V., Bunev A. S., Presnukhina S., Shetnev A., Zubkov F. I. Straightforward Three-Component Synthesis of N′,N′′-Disubstituted N -Alkyl-1,3,5-Triazinanes // Synlett. 2020. Vol. 31. No. 11. pp. 1067-1072.
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TY - JOUR
DO - 10.1055/s-0039-1690900
UR - https://doi.org/10.1055%2Fs-0039-1690900
TI - Straightforward Three-Component Synthesis of N′,N′′-Disubstituted N -Alkyl-1,3,5-Triazinanes
T2 - Synlett
AU - Kletskov, Alexey V
AU - Frontera, Antonio
AU - Sinelshchikova, Anna A
AU - Grigoriev, Mikhail S.
AU - Zaytsev, Vladimir P.
AU - Grudova, Mariya V
AU - Bunev, Alexander S.
AU - Presnukhina, Sofia
AU - Shetnev, Anton
AU - Zubkov, Fedor I.
PY - 2020
DA - 2020/04/17 00:00:00
PB - Thieme
SP - 1067-1072
IS - 11
VL - 31
SN - 0936-5214
SN - 1437-2096
ER -
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@article{2020_Kletskov,
author = {Alexey V Kletskov and Antonio Frontera and Anna A Sinelshchikova and Mikhail S. Grigoriev and Vladimir P. Zaytsev and Mariya V Grudova and Alexander S. Bunev and Sofia Presnukhina and Anton Shetnev and Fedor I. Zubkov},
title = {Straightforward Three-Component Synthesis of N′,N′′-Disubstituted N -Alkyl-1,3,5-Triazinanes},
journal = {Synlett},
year = {2020},
volume = {31},
publisher = {Thieme},
month = {apr},
url = {https://doi.org/10.1055%2Fs-0039-1690900},
number = {11},
pages = {1067--1072},
doi = {10.1055/s-0039-1690900}
}
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MLA
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Kletskov, Alexey V., et al. “Straightforward Three-Component Synthesis of N′,N′′-Disubstituted N -Alkyl-1,3,5-Triazinanes.” Synlett, vol. 31, no. 11, Apr. 2020, pp. 1067-1072. https://doi.org/10.1055%2Fs-0039-1690900.