Gynecological Endocrinology, volume 35, issue sup1, pages 5-10
NK and trophoblast cells interaction: cytotoxic activity on recurrent pregnancy loss
Publication type: Journal Article
Publication date: 2019-07-31
Journal:
Gynecological Endocrinology
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 2
ISSN: 09513590, 14730766
Endocrinology
Endocrinology, Diabetes and Metabolism
Obstetrics and Gynecology
Abstract
The trial objective was to determine the peripheral blood NK cells cytotoxic activity effect on trophoblast cells at recurrent pregnancy loss (RPL). The investigation involved non-pregnant women with PRL in proliferating and secretory menstrual cycle phases (PMCPh and SMCPh, respectively); women of 6–7 weeks pregnancy with RPL in past medical history; healthy fertile non-pregnant women in PMCPh and SMCPh, women of 6–7 weeks physiological pregnancy, nulliparity healthy women with regular menstrual function in PMCPh and SMCPh. NK cells cytotoxic activity was determined using peripheral blood mononuclear cells. The target cells were JEG-3 line trophoblasts. It has been established that NK cells cytotoxic activity effect on trophoblasts is lower in SMCPh than in PMCPh in non-pregnant fertile women. The NK cells cytotoxic activity was higher in SMCPh than in PMCPh in non-pregnant women with PRL and also higher than the same value in SMCPh in non-pregnant fertile women. The increased NK cells cytotoxic activity values in SMCPh in women with RPL may be the reason for miscarriage.
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Citations by publishers
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Multidisciplinary Digital Publishing Institute (MDPI)
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3 publications, 33.33%
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1 publication, 11.11%
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American Physiological Society
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1 publication, 11.11%
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Taylor & Francis
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1 publication, 11.11%
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Media Sphere Publishing Group
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1 publication, 11.11%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Sokolov D. I. et al. NK and trophoblast cells interaction: cytotoxic activity on recurrent pregnancy loss // Gynecological Endocrinology. 2019. Vol. 35. No. sup1. pp. 5-10.
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Sokolov D. I., Mikhailova V., Agnayeva A. O., Bazhenov D. O., Khokhlova E. V., Bespalova O. N., Gzgzyan A. M., Selkov S. A. NK and trophoblast cells interaction: cytotoxic activity on recurrent pregnancy loss // Gynecological Endocrinology. 2019. Vol. 35. No. sup1. pp. 5-10.
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TY - JOUR
DO - 10.1080/09513590.2019.1632084
UR - https://doi.org/10.1080%2F09513590.2019.1632084
TI - NK and trophoblast cells interaction: cytotoxic activity on recurrent pregnancy loss
T2 - Gynecological Endocrinology
AU - Sokolov, Dmitry I.
AU - Mikhailova, Valentina
AU - Agnayeva, Alana O
AU - Bazhenov, Dmitry O
AU - Khokhlova, Evgeniya V
AU - Bespalova, Olesya N
AU - Gzgzyan, Alexander M.
AU - Selkov, S. A.
PY - 2019
DA - 2019/07/31 00:00:00
PB - Taylor & Francis
SP - 5-10
IS - sup1
VL - 35
SN - 0951-3590
SN - 1473-0766
ER -
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@article{2019_Sokolov,
author = {Dmitry I. Sokolov and Valentina Mikhailova and Alana O Agnayeva and Dmitry O Bazhenov and Evgeniya V Khokhlova and Olesya N Bespalova and Alexander M. Gzgzyan and S. A. Selkov},
title = {NK and trophoblast cells interaction: cytotoxic activity on recurrent pregnancy loss},
journal = {Gynecological Endocrinology},
year = {2019},
volume = {35},
publisher = {Taylor & Francis},
month = {jul},
url = {https://doi.org/10.1080%2F09513590.2019.1632084},
number = {sup1},
pages = {5--10},
doi = {10.1080/09513590.2019.1632084}
}
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MLA
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Sokolov, Dmitry I., et al. “NK and trophoblast cells interaction: cytotoxic activity on recurrent pregnancy loss.” Gynecological Endocrinology, vol. 35, no. sup1, Jul. 2019, pp. 5-10. https://doi.org/10.1080%2F09513590.2019.1632084.