Synthetic Approaches to Cytotoxic Amidophosphates, Aminophosphonates, and Aminobisphosphonates with 3,5-Bis(arylidene)piperid-4-one Framework
Michael V. Makarov
1
,
Evgenia S Leonova
1
,
Ekaterina V Matveeva
1
,
Gerd-Volker Röschenthaler
3
,
Irina L. Odinets
1
Publication type: Journal Article
Publication date: 2011-03-31
scimago Q4
wos Q3
SJR: 0.264
CiteScore: 2.6
Impact factor: 1.6
ISSN: 10426507, 15635325, 10267719
Organic Chemistry
Biochemistry
Inorganic Chemistry
Abstract
Abstract Facile synthetic approaches to a few novel classes of amidophosphates, ω-aminophosphonates, and bisphosphonates having a 3,5-bis(arylidene)piperid-4-one backbone have been elaborated starting from piperid-4-ones functionalized with phosphorus motives followed by aldol-crotonic condensation with a range of (hetero)aromatic aldehydes or via introduction of the corresponding phosphorus function into the preformed NH-3,5-bis(arylidene)piperid-4-ones. Combination of phosphorus-containing moieties possessing inherent bioactivity and cytotoxic 3,5-bis(arylidene)piperid-4-one moiety resulted in the compounds with high antitumor activity towards human carcinoma cell lines Caov3, A549, Scov3, PC3, KB 3-1, and KB 8–5 (IC50 in the range of 1–80 μM).
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Total citations:
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Citations from 2024:
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Makarov M. V. et al. Synthetic Approaches to Cytotoxic Amidophosphates, Aminophosphonates, and Aminobisphosphonates with 3,5-Bis(arylidene)piperid-4-one Framework // Phosphorus, Sulfur and Silicon and the Related Elements. 2011. Vol. 186. No. 4. pp. 908-917.
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Makarov M. V., Leonova E. S., Matveeva E. V., Rybalkina E. Yu., Röschenthaler G., Timofeeva T. A., Odinets I. L. Synthetic Approaches to Cytotoxic Amidophosphates, Aminophosphonates, and Aminobisphosphonates with 3,5-Bis(arylidene)piperid-4-one Framework // Phosphorus, Sulfur and Silicon and the Related Elements. 2011. Vol. 186. No. 4. pp. 908-917.
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RIS
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TY - JOUR
DO - 10.1080/10426507.2010.514308
UR - https://doi.org/10.1080/10426507.2010.514308
TI - Synthetic Approaches to Cytotoxic Amidophosphates, Aminophosphonates, and Aminobisphosphonates with 3,5-Bis(arylidene)piperid-4-one Framework
T2 - Phosphorus, Sulfur and Silicon and the Related Elements
AU - Makarov, Michael V.
AU - Leonova, Evgenia S
AU - Matveeva, Ekaterina V
AU - Rybalkina, Ekaterina Yu
AU - Röschenthaler, Gerd-Volker
AU - Timofeeva, Tatiana A.
AU - Odinets, Irina L.
PY - 2011
DA - 2011/03/31
PB - Taylor & Francis
SP - 908-917
IS - 4
VL - 186
SN - 1042-6507
SN - 1563-5325
SN - 1026-7719
ER -
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BibTex (up to 50 authors)
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@article{2011_Makarov,
author = {Michael V. Makarov and Evgenia S Leonova and Ekaterina V Matveeva and Ekaterina Yu Rybalkina and Gerd-Volker Röschenthaler and Tatiana A. Timofeeva and Irina L. Odinets},
title = {Synthetic Approaches to Cytotoxic Amidophosphates, Aminophosphonates, and Aminobisphosphonates with 3,5-Bis(arylidene)piperid-4-one Framework},
journal = {Phosphorus, Sulfur and Silicon and the Related Elements},
year = {2011},
volume = {186},
publisher = {Taylor & Francis},
month = {mar},
url = {https://doi.org/10.1080/10426507.2010.514308},
number = {4},
pages = {908--917},
doi = {10.1080/10426507.2010.514308}
}
Cite this
MLA
Copy
Makarov, Michael V., et al. “Synthetic Approaches to Cytotoxic Amidophosphates, Aminophosphonates, and Aminobisphosphonates with 3,5-Bis(arylidene)piperid-4-one Framework.” Phosphorus, Sulfur and Silicon and the Related Elements, vol. 186, no. 4, Mar. 2011, pp. 908-917. https://doi.org/10.1080/10426507.2010.514308.