Open Access

Nucleus, издание 8, том 6, страницы 641-653

Interstitial telomeric repeats-associated DNA breaks

Shubernetskaya Olga ¹

Skvortsov Dmitry ¹

Evfratov Sergey ¹

Rubtsova Maria ¹

Belova Elena ¹

Strelkova Olga ²

Cherepaninets Varvara ²

Zhironkina Oxana ²

Olovnikov Alexey ³

Zvereva Maria ^{1, 2}

Dontsova Olga ^{1, 2, 4}

Kireev I. ²

Kireev Igor ²

Chemistry department, M.V. Lomonosov Moscow State University, Moscow, Russia

A.N. Belozersky Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State University, Moscow, Russia

Institute of Biochemical Physics, RAS, Moscow, Russia

⁴

Skolkovo Institute of Science and Technology, Skolkovo, Moscow, Russia

Тип публикации: Journal Article

Дата публикации: 2017-09-15

Taylor & Francis

Журнал: Nucleus

Квартиль SCImago: Q1

Квартиль WOS: Q3

Impact factor: 3.7

ISSN: 19491034, 19491042, 0864084X, 20755635

DOI: 10.1080/19491034.2017.1356501

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PubMed ID: 28914588

Cell Biology

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ABSTRACT During a cell's lifespan, DNA break formation is a common event, associated with many processes, from replication to apoptosis. Most of DNA breaks are readily repaired, but some are meant to persist in time, such as the chromosome ends, protected by telomeres. Besides them, eukaryotic genomes comprise shorter stretches of interstitial telomeric repeats. We assumed that the latter may also be associated with the formation of DNA breaks meant to persist in time. In zebrafish and mouse embryos, cells containing numerous breakage foci were identified. These breaks were not associated with apoptosis or replication, nor did they seem to activate DNA damage response machinery. Unlike short-living, accidental sparse breaks, the ones we found seem to be closely associated, forming discrete break foci. A PCR-based method was developed, allowing specific amplification of DNA regions located between inverted telomeric repeats associated with breaks. The cloning and sequencing of such DNA fragments were found to denote some specificity in their distribution for different tissue types and development stages.

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	1
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 16.67% International Journal of Molecular Sciences 1 публикация, 16.67%
Psicologia Ciência e Profissão	Psicologia Ciência e Profissão, 1, 16.67% Psicologia Ciência e Profissão 1 публикация, 16.67%
	1

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Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 1, 16.67% Multidisciplinary Digital Publishing Institute (MDPI) 1 публикация, 16.67%
SciELO	SciELO, 1, 16.67% SciELO 1 публикация, 16.67%
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Shubernetskaya O. et al. Interstitial telomeric repeats-associated DNA breaks // Nucleus. 2017. Vol. 8. No. 6. pp. 641-653.

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Shubernetskaya O., Skvortsov D., Evfratov S., Rubtsova M., Belova E., Strelkova O., Cherepaninets V., Zhironkina O., Olovnikov A., Zvereva M., Dontsova O., Kireev I., Kireev I. Interstitial telomeric repeats-associated DNA breaks // Nucleus. 2017. Vol. 8. No. 6. pp. 641-653.

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TY - JOUR

DO - 10.1080/19491034.2017.1356501

UR - https://doi.org/10.1080/19491034.2017.1356501

TI - Interstitial telomeric repeats-associated DNA breaks

T2 - Nucleus

AU - Shubernetskaya, Olga

AU - Skvortsov, Dmitry

AU - Cherepaninets, Varvara

AU - Zhironkina, Oxana

AU - Olovnikov, Alexey

AU - Dontsova, Olga

AU - Kireev, Igor

AU - Evfratov, Sergey

AU - Rubtsova, Maria

AU - Belova, Elena

AU - Strelkova, Olga

AU - Zvereva, Maria

AU - Kireev, I.

PY - 2017

DA - 2017/09/15 00:00:00

PB - Taylor & Francis

SP - 641-653

IS - 6

VL - 8

PMID - 28914588

SN - 1949-1034

SN - 1949-1042

SN - 0864-084X

SN - 2075-5635

ER -

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@article{2017_Shubernetskaya

author = {Olga Shubernetskaya and Dmitry Skvortsov and Varvara Cherepaninets and Oxana Zhironkina and Alexey Olovnikov and Olga Dontsova and Igor Kireev and Sergey Evfratov and Maria Rubtsova and Elena Belova and Olga Strelkova and Maria Zvereva and I. Kireev},

title = {Interstitial telomeric repeats-associated DNA breaks},

journal = {Nucleus},

year = {2017},

volume = {8},

publisher = {Taylor & Francis},

month = {sep},

url = {https://doi.org/10.1080/19491034.2017.1356501},

number = {6},

pages = {641--653},

doi = {10.1080/19491034.2017.1356501}

}

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Shubernetskaya, Olga, et al. “Interstitial telomeric repeats-associated DNA breaks.” Nucleus, vol. 8, no. 6, Sep. 2017, pp. 641-653. https://doi.org/10.1080/19491034.2017.1356501.

Издатель

Taylor & Francis

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Nucleus

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Квартиль WOS

Impact factor

3.7

ISSN

19491034 (Print)
19491042 (Electronic)
0864084X (Print)
20755635 (Electronic)

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