Open Access
Nucleus, volume 8, issue 6, pages 641-653
Interstitial telomeric repeats-associated DNA breaks
Shubernetskaya Olga
1
,
Skvortsov Dmitry
1
,
Evfratov Sergey
1
,
Rubtsova Maria
1
,
Belova Elena
1
,
Strelkova Olga
2
,
Cherepaninets Varvara
2
,
Zhironkina Oxana
2
,
Olovnikov Alexey
3
,
Zvereva Maria
1, 2
,
Dontsova Olga
1, 2, 4
,
Kireev I.
2
,
Kireev Igor
2
Publication type: Journal Article
Publication date: 2017-09-15
Journal:
Nucleus
Quartile SCImago
Q1
Quartile WOS
Q3
Impact factor: 3.7
ISSN: 19491034, 19491042, 0864084X, 20755635
PubMed ID:
28914588
Cell Biology
Abstract
ABSTRACT During a cell's lifespan, DNA break formation is a common event, associated with many processes, from replication to apoptosis. Most of DNA breaks are readily repaired, but some are meant to persist in time, such as the chromosome ends, protected by telomeres. Besides them, eukaryotic genomes comprise shorter stretches of interstitial telomeric repeats. We assumed that the latter may also be associated with the formation of DNA breaks meant to persist in time. In zebrafish and mouse embryos, cells containing numerous breakage foci were identified. These breaks were not associated with apoptosis or replication, nor did they seem to activate DNA damage response machinery. Unlike short-living, accidental sparse breaks, the ones we found seem to be closely associated, forming discrete break foci. A PCR-based method was developed, allowing specific amplification of DNA regions located between inverted telomeric repeats associated with breaks. The cloning and sequencing of such DNA fragments were found to denote some specificity in their distribution for different tissue types and development stages.
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Citations by publishers
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1 publication, 16.67%
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1 publication, 16.67%
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SciELO
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1 publication, 16.67%
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1
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Shubernetskaya O. et al. Interstitial telomeric repeats-associated DNA breaks // Nucleus. 2017. Vol. 8. No. 6. pp. 641-653.
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Shubernetskaya O., Skvortsov D., Evfratov S., Rubtsova M., Belova E., Strelkova O., Cherepaninets V., Zhironkina O., Olovnikov A., Zvereva M., Dontsova O., Kireev I., Kireev I. Interstitial telomeric repeats-associated DNA breaks // Nucleus. 2017. Vol. 8. No. 6. pp. 641-653.
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TY - JOUR
DO - 10.1080/19491034.2017.1356501
UR - https://doi.org/10.1080%2F19491034.2017.1356501
TI - Interstitial telomeric repeats-associated DNA breaks
T2 - Nucleus
AU - Shubernetskaya, Olga
AU - Skvortsov, Dmitry
AU - Cherepaninets, Varvara
AU - Zhironkina, Oxana
AU - Olovnikov, Alexey
AU - Dontsova, Olga
AU - Kireev, Igor
AU - Evfratov, Sergey
AU - Rubtsova, Maria
AU - Belova, Elena
AU - Strelkova, Olga
AU - Zvereva, Maria
AU - Kireev, I.
PY - 2017
DA - 2017/09/15 00:00:00
PB - Taylor & Francis
SP - 641-653
IS - 6
VL - 8
PMID - 28914588
SN - 1949-1034
SN - 1949-1042
SN - 0864-084X
SN - 2075-5635
ER -
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@article{2017_Shubernetskaya,
author = {Olga Shubernetskaya and Dmitry Skvortsov and Varvara Cherepaninets and Oxana Zhironkina and Alexey Olovnikov and Olga Dontsova and Igor Kireev and Sergey Evfratov and Maria Rubtsova and Elena Belova and Olga Strelkova and Maria Zvereva and I. Kireev},
title = {Interstitial telomeric repeats-associated DNA breaks},
journal = {Nucleus},
year = {2017},
volume = {8},
publisher = {Taylor & Francis},
month = {sep},
url = {https://doi.org/10.1080%2F19491034.2017.1356501},
number = {6},
pages = {641--653},
doi = {10.1080/19491034.2017.1356501}
}
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MLA
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Shubernetskaya, Olga, et al. “Interstitial telomeric repeats-associated DNA breaks.” Nucleus, vol. 8, no. 6, Sep. 2017, pp. 641-653. https://doi.org/10.1080%2F19491034.2017.1356501.