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Nucleus, том 8, издание 6, номера страниц: 641-653

Interstitial telomeric repeats-associated DNA breaks

Shubernetskaya Olga 1
Evfratov Sergey 1
Belova Elena 1
Strelkova Olga 2
Cherepaninets Varvara 2
Olovnikov Alexey 3
Zvereva Maria 1, 2
Dontsova Olga 1, 2, 4
Тип документаJournal Article
Дата публикации2017-09-15
ИздательTaylor & Francis
Название журналаNucleus
Квартиль по SCImagoQ1
Квартиль по Web of ScienceQ3
Импакт-фактор 20214.59
ISSN19491034, 19491042
Cell Biology
Краткое описание
ABSTRACT During a cell's lifespan, DNA break formation is a common event, associated with many processes, from replication to apoptosis. Most of DNA breaks are readily repaired, but some are meant to persist in time, such as the chromosome ends, protected by telomeres. Besides them, eukaryotic genomes comprise shorter stretches of interstitial telomeric repeats. We assumed that the latter may also be associated with the formation of DNA breaks meant to persist in time. In zebrafish and mouse embryos, cells containing numerous breakage foci were identified. These breaks were not associated with apoptosis or replication, nor did they seem to activate DNA damage response machinery. Unlike short-living, accidental sparse breaks, the ones we found seem to be closely associated, forming discrete break foci. A PCR-based method was developed, allowing specific amplification of DNA regions located between inverted telomeric repeats associated with breaks. The cloning and sequencing of such DNA fragments were found to denote some specificity in their distribution for different tissue types and development stages.
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1. Shubernetskaya O. и др. Interstitial telomeric repeats-associated DNA breaks // Nucleus. 2017. Т. 8. № 6. С. 641–653.
RIS |
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TY - JOUR

DO - 10.1080/19491034.2017.1356501

UR - http://dx.doi.org/10.1080/19491034.2017.1356501

TI - Interstitial telomeric repeats-associated DNA breaks

T2 - Nucleus

AU - Shubernetskaya, Olga

AU - Skvortsov, Dmitry

AU - Evfratov, Sergey

AU - Rubtsova, Maria

AU - Belova, Elena

AU - Strelkova, Olga

AU - Cherepaninets, Varvara

AU - Zhironkina, Oxana

AU - Olovnikov, Alexey

AU - Zvereva, Maria

AU - Dontsova, Olga

AU - Kireev, Igor

PY - 2017

DA - 2017/09/15

PB - Informa UK Limited

SP - 641-653

IS - 6

VL - 8

SN - 1949-1034

SN - 1949-1042

ER -

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@article{2017,

doi = {10.1080/19491034.2017.1356501},

url = {https://doi.org/10.1080%2F19491034.2017.1356501},

year = 2017,

month = {sep},

publisher = {Informa {UK} Limited},

volume = {8},

number = {6},

pages = {641--653},

author = {Olga Shubernetskaya and Dmitry Skvortsov and Sergey Evfratov and Maria Rubtsova and Elena Belova and Olga Strelkova and Varvara Cherepaninets and Oxana Zhironkina and Alexey Olovnikov and Maria Zvereva and Olga Dontsova and Igor Kireev},

title = {Interstitial telomeric repeats-associated {DNA} breaks}

}

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Shubernetskaya, Olga et al. “Interstitial Telomeric Repeats-Associated DNA Breaks.” Nucleus 8.6 (2017): 641–653. Crossref. Web.