Automated assay of oxygen radical absorbance capacity with the COBAS FARA II
Publication type: Journal Article
Publication date: 1995-12-01
scimago Q1
wos Q1
SJR: 1.345
CiteScore: 9.7
Impact factor: 6.3
ISSN: 00099147, 15308561
Clinical Biochemistry
Biochemistry (medical)
Abstract
Reactive oxygen species are of interest in biology and medicine because of evidence relating them to aging and disease processes. A relatively simple but sensitive and reliable method for quantifying the oxygen radical absorbance capacity (ORAC) of antioxidants in biological tissues has been automated for use with the COBAS FARA II centrifugal analyzer with a fluorescence-measuring attachment. In this assay, beta-phycoerythrin (beta-PE) is used as an indicator protein, 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH) as a peroxyl radical generator, and 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox) as a calibrator for antioxidant activity. This assay is unique because the reaction goes to completion so that both inhibition time and inhibition degree are considered in quantifying ORAC (micromoles of Trolox equivalent per liter or per gram of tissue). This method can be used not only for serum but also other tissue and food samples and is suitable for application to a range of nutritional and clinical conditions.
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Metrics
256
Total citations:
256
Citations from 2024:
3
(1.17%)
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GOST
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Cao G. et al. Automated assay of oxygen radical absorbance capacity with the COBAS FARA II // Clinical Chemistry. 1995. Vol. 41. No. 12. pp. 1738-1744.
GOST all authors (up to 50)
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Cao G., Verdon C. P., Wu A. H., Wang H., Prior R. L. Automated assay of oxygen radical absorbance capacity with the COBAS FARA II // Clinical Chemistry. 1995. Vol. 41. No. 12. pp. 1738-1744.
Cite this
RIS
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TY - JOUR
DO - 10.1093/clinchem/41.12.1738
UR - https://doi.org/10.1093/clinchem/41.12.1738
TI - Automated assay of oxygen radical absorbance capacity with the COBAS FARA II
T2 - Clinical Chemistry
AU - Cao, G.
AU - Verdon, C. P.
AU - Wu, A H
AU - Wang, H.
AU - Prior, R. L.
PY - 1995
DA - 1995/12/01
PB - American Association for Clinical Chemistry
SP - 1738-1744
IS - 12
VL - 41
SN - 0009-9147
SN - 1530-8561
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1995_Cao,
author = {G. Cao and C. P. Verdon and A H Wu and H. Wang and R. L. Prior},
title = {Automated assay of oxygen radical absorbance capacity with the COBAS FARA II},
journal = {Clinical Chemistry},
year = {1995},
volume = {41},
publisher = {American Association for Clinical Chemistry},
month = {dec},
url = {https://doi.org/10.1093/clinchem/41.12.1738},
number = {12},
pages = {1738--1744},
doi = {10.1093/clinchem/41.12.1738}
}
Cite this
MLA
Copy
Cao, G., et al. “Automated assay of oxygen radical absorbance capacity with the COBAS FARA II.” Clinical Chemistry, vol. 41, no. 12, Dec. 1995, pp. 1738-1744. https://doi.org/10.1093/clinchem/41.12.1738.