From 2003 to 2005, 813 patients were included if they had early arthritis (<6 months) with a high probability of RA and had never been prescribed DMARDs. Multivariate analysis was used to evaluate predictors of outcome.

Results

In total, 521 (64.1%) RA patients were followed up for 10 years; 35 (4.3%) died, which appears to be similar to the French general population. Overall, 480 (92.1%) patients received a DMARD; 174 (33.4%) received at least one biologic DMARD, 13.6% within 2 years. At year 10, 273 (52.4%) patients were in DAS28 remission, 40.1% in sustained remission, 14.1% in drug-free remission, 39.7% in CDAI remission. Half of the patients achieved a health assessment questionnaire-disability index (HAQ-DI) < 0.5. SF-36 physical component and pain were well controlled. Structural progression was weak, with a mean change from baseline in modified Sharp score of 11.0 (17.9). Only 34 (6.5%) patients required major joint surgery. A substantial number of patients showed new comorbidities over 10 years. Positivity for anti-citrullinated peptides antibodies (ACPA) was confirmed as a robust predictor of long-term outcome.

Conclusions

We report a very mild 10-year outcome of a large cohort of patients with early RA diagnosed in the early 2000s, which was much better than results for a previous cohort of patients who were recruited in 1993. This current favourable outcome may be related to more intensive care for real-life patients.

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GOST |

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GOST Copy

Combe B. et al. Current favourable 10-year outcome of patients with early rheumatoid arthritis: data from the ESPOIR cohort // Rheumatology. 2021. Vol. 60. No. 11. pp. 5073-5079.

GOST all authors (up to 50) Copy

Combe B., Rincheval N., Berenbaum F., Boumier P., Cantagrel A., Dieude P., DOUGADOS M., Fautrel B., Flipo R., GOUPILLE P., Mariette X., Saraux A., Schaeverbeke T., Sibilia J., Vittecoq O., DAURES J. Current favourable 10-year outcome of patients with early rheumatoid arthritis: data from the ESPOIR cohort // Rheumatology. 2021. Vol. 60. No. 11. pp. 5073-5079.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1093/rheumatology/keab398

UR - https://doi.org/10.1093/rheumatology/keab398

TI - Current favourable 10-year outcome of patients with early rheumatoid arthritis: data from the ESPOIR cohort

T2 - Rheumatology

AU - Combe, Bernard

AU - Rincheval, Nathalie

AU - Berenbaum, Francis

AU - Boumier, Patrick

AU - Cantagrel, Alain

AU - Dieude, Philippe

AU - DOUGADOS, MAXIME

AU - Fautrel, Bruno

AU - Flipo, René-Marc

AU - GOUPILLE, P

AU - Mariette, Xavier

AU - Saraux, Alain

AU - Schaeverbeke, Thierry

AU - Sibilia, Jean

AU - Vittecoq, Olivier

AU - DAURES, JEAN-PIERRE

PY - 2021

DA - 2021/05/07

PB - Oxford University Press

SP - 5073-5079

IS - 11

VL - 60

PMID - 33961011

SN - 1462-0324

SN - 1462-0332

SN - 1460-2172

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{2021_Combe,

author = {Bernard Combe and Nathalie Rincheval and Francis Berenbaum and Patrick Boumier and Alain Cantagrel and Philippe Dieude and MAXIME DOUGADOS and Bruno Fautrel and René-Marc Flipo and P GOUPILLE and Xavier Mariette and Alain Saraux and Thierry Schaeverbeke and Jean Sibilia and Olivier Vittecoq and JEAN-PIERRE DAURES},

title = {Current favourable 10-year outcome of patients with early rheumatoid arthritis: data from the ESPOIR cohort},

journal = {Rheumatology},

year = {2021},

volume = {60},

publisher = {Oxford University Press},

month = {may},

url = {https://doi.org/10.1093/rheumatology/keab398},

number = {11},

pages = {5073--5079},

doi = {10.1093/rheumatology/keab398}

}

MLA

Cite this

MLA Copy

Combe, Bernard, et al. “Current favourable 10-year outcome of patients with early rheumatoid arthritis: data from the ESPOIR cohort.” Rheumatology, vol. 60, no. 11, May. 2021, pp. 5073-5079. https://doi.org/10.1093/rheumatology/keab398.

Publisher

Oxford University Press

Journal

Rheumatology

scimago Q1

wos Q1

SJR

1.721

CiteScore

9.9

Impact factor

4.4

ISSN

14620324 (Print)

14620332 (Electronic)

14602172 (Electronic)