Open Access
Open access
Oxford University Press
Antibody Therapeutics
,  volume 4 ,  issue 1 ,  pages 1-15

Challenges and opportunities to develop enediyne natural products as payloads for antibody-drug conjugates

Publication type: Journal Article
Publication date: 2021-01-01
Oxford University Press
scimago Q1
wos Q2
SJR: 1.314
CiteScore: 8.4
Impact factor: 4.5
ISSN: 25164236
DOI:  10.1093/abt/tbab001
PubMed ID:  33554043
Immunology
Immunology and Allergy
Abstract

Calicheamicin, the payload of the antibody-drug-conjugates (ADCs) gemtuzumab ozogamicin (Mylotarg®) and inotuzumab ozogamicin (Besponsa®), belongs to the class of enediyne natural products. Since the isolation and structural determination of the neocarzinostatin chromophore in 1985, the enediynes have attracted considerable attention for their value as DNA damaging agents in cancer chemotherapy. Due to their non-discriminatory cytotoxicity towards both cancer and healthy cells, the clinical utilization of enediyne natural products relies on conjugation to an appropriate delivery system, such as an antibody. Here, we review the current landscape of enediynes as payloads of first-generation and next-generation ADCs.

Found 
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Cite this
GOST |
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GOST Copy
Adhikari A. et al. Challenges and opportunities to develop enediyne natural products as payloads for antibody-drug conjugates // Antibody Therapeutics. 2021. Vol. 4. No. 1. pp. 1-15.
GOST all authors (up to 50) Copy
Adhikari A., Shen B., Rader C. P. Challenges and opportunities to develop enediyne natural products as payloads for antibody-drug conjugates // Antibody Therapeutics. 2021. Vol. 4. No. 1. pp. 1-15.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1093/abt/tbab001
UR - https://academic.oup.com/abt/article/4/1/1/6089012
TI - Challenges and opportunities to develop enediyne natural products as payloads for antibody-drug conjugates
T2 - Antibody Therapeutics
AU - Adhikari, Ajeeth
AU - Shen, Ben
AU - Rader, Christoph P.
PY - 2021
DA - 2021/01/01
PB - Oxford University Press
SP - 1-15
IS - 1
VL - 4
PMID - 33554043
SN - 2516-4236
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2021_Adhikari,
author = {Ajeeth Adhikari and Ben Shen and Christoph P. Rader},
title = {Challenges and opportunities to develop enediyne natural products as payloads for antibody-drug conjugates},
journal = {Antibody Therapeutics},
year = {2021},
volume = {4},
publisher = {Oxford University Press},
month = {jan},
url = {https://academic.oup.com/abt/article/4/1/1/6089012},
number = {1},
pages = {1--15},
doi = {10.1093/abt/tbab001}
}
MLA
Cite this
MLA Copy
Adhikari, Ajeeth, et al. “Challenges and opportunities to develop enediyne natural products as payloads for antibody-drug conjugates.” Antibody Therapeutics, vol. 4, no. 1, Jan. 2021, pp. 1-15. https://academic.oup.com/abt/article/4/1/1/6089012.