Open Access
Nucleic Acids Research, volume 33, issue Web Server, pages W244-W248
The HHpred interactive server for protein homology detection and structure prediction
Publication type: Journal Article
Publication date: 2005-07-01
Journal:
Nucleic Acids Research
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 14.9
ISSN: 03051048, 13624962
PubMed ID:
15980461
Genetics
Abstract
HHpred is a fast server for remote protein homology detection and structure prediction and is the first to implement pairwise comparison of profile hidden Markov models (HMMs). It allows to search a wide choice of databases, such as the PDB, SCOP, Pfam, SMART, COGs and CDD. It accepts a single query sequence or a multiple alignment as input. Within only a few minutes it returns the search results in a user-friendly format similar to that of PSI-BLAST. Search options include local or global alignment and scoring secondary structure similarity. HHpred can produce pairwise query-template alignments, multiple alignments of the query with a set of templates selected from the search results, as well as 3D structural models that are calculated by the MODELLER software from these alignments. A detailed help facility is available. As a demonstration, we analyze the sequence of SpoVT, a transcriptional regulator from Bacillus subtilis. HHpred can be accessed at http://protevo.eb.tuebingen.mpg.de/hhpred.
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Söding J., Biegert A., Lupas A. N. The HHpred interactive server for protein homology detection and structure prediction // Nucleic Acids Research. 2005. Vol. 33. No. Web Server. p. W244-W248.
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Söding J., Biegert A., Lupas A. N. The HHpred interactive server for protein homology detection and structure prediction // Nucleic Acids Research. 2005. Vol. 33. No. Web Server. p. W244-W248.
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TY - JOUR
DO - 10.1093/nar/gki408
UR - https://doi.org/10.1093/nar/gki408
TI - The HHpred interactive server for protein homology detection and structure prediction
T2 - Nucleic Acids Research
AU - Söding, Johannes
AU - Biegert, A
AU - Lupas, Andrei N.
PY - 2005
DA - 2005/07/01
PB - Oxford University Press
SP - W244-W248
IS - Web Server
VL - 33
PMID - 15980461
SN - 0305-1048
SN - 1362-4962
ER -
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BibTex
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@article{2005_Söding,
author = {Johannes Söding and A Biegert and Andrei N. Lupas},
title = {The HHpred interactive server for protein homology detection and structure prediction},
journal = {Nucleic Acids Research},
year = {2005},
volume = {33},
publisher = {Oxford University Press},
month = {jul},
url = {https://doi.org/10.1093/nar/gki408},
number = {Web Server},
pages = {W244--W248},
doi = {10.1093/nar/gki408}
}
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Söding, Johannes, et al. “The HHpred interactive server for protein homology detection and structure prediction.” Nucleic Acids Research, vol. 33, no. Web Server, Jul. 2005, pp. W244-W248. https://doi.org/10.1093/nar/gki408.