Open Access
The HHpred interactive server for protein homology detection and structure prediction
Publication type: Journal Article
Publication date: 2005-07-01
scimago Q1
wos Q1
SJR: 7.776
CiteScore: 31.7
Impact factor: 13.1
ISSN: 03051048, 13624962
PubMed ID:
15980461
Genetics
Abstract
HHpred is a fast server for remote protein homology detection and structure prediction and is the first to implement pairwise comparison of profile hidden Markov models (HMMs). It allows to search a wide choice of databases, such as the PDB, SCOP, Pfam, SMART, COGs and CDD. It accepts a single query sequence or a multiple alignment as input. Within only a few minutes it returns the search results in a user-friendly format similar to that of PSI-BLAST. Search options include local or global alignment and scoring secondary structure similarity. HHpred can produce pairwise query-template alignments, multiple alignments of the query with a set of templates selected from the search results, as well as 3D structural models that are calculated by the MODELLER software from these alignments. A detailed help facility is available. As a demonstration, we analyze the sequence of SpoVT, a transcriptional regulator from Bacillus subtilis. HHpred can be accessed at http://protevo.eb.tuebingen.mpg.de/hhpred.
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Söding J., Biegert A., Lupas A. N. The HHpred interactive server for protein homology detection and structure prediction // Nucleic Acids Research. 2005. Vol. 33. No. Web Server. p. W244-W248.
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Söding J., Biegert A., Lupas A. N. The HHpred interactive server for protein homology detection and structure prediction // Nucleic Acids Research. 2005. Vol. 33. No. Web Server. p. W244-W248.
Cite this
RIS
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TY - JOUR
DO - 10.1093/nar/gki408
UR - https://doi.org/10.1093/nar/gki408
TI - The HHpred interactive server for protein homology detection and structure prediction
T2 - Nucleic Acids Research
AU - Söding, Johannes
AU - Biegert, A
AU - Lupas, Andrei N.
PY - 2005
DA - 2005/07/01
PB - Oxford University Press
SP - W244-W248
IS - Web Server
VL - 33
PMID - 15980461
SN - 0305-1048
SN - 1362-4962
ER -
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BibTex (up to 50 authors)
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@article{2005_Söding,
author = {Johannes Söding and A Biegert and Andrei N. Lupas},
title = {The HHpred interactive server for protein homology detection and structure prediction},
journal = {Nucleic Acids Research},
year = {2005},
volume = {33},
publisher = {Oxford University Press},
month = {jul},
url = {https://doi.org/10.1093/nar/gki408},
number = {Web Server},
pages = {W244--W248},
doi = {10.1093/nar/gki408}
}
Cite this
MLA
Copy
Söding, Johannes, et al. “The HHpred interactive server for protein homology detection and structure prediction.” Nucleic Acids Research, vol. 33, no. Web Server, Jul. 2005, pp. W244-W248. https://doi.org/10.1093/nar/gki408.