Open Access
Ribosomal RNA guanine-(N2)-methyltransferases and their targets
Publication type: Journal Article
Publication date: 2007-03-27
scimago Q1
wos Q1
SJR: 7.776
CiteScore: 31.7
Impact factor: 13.1
ISSN: 03051048, 13624962
PubMed ID:
17389639
Genetics
Abstract
Five nearly universal methylated guanine-(N2) residues are present in bacterial rRNA in the ribosome. To date four out of five ribosomal RNA guanine-(N2)-methyltransferases are described. RsmC(YjjT) methylates G1207 of the 16S rRNA. RlmG(YgjO) and RlmL(YcbY) are responsible for the 23S rRNA m(2)G1835 and m(2)G2445 formation, correspondingly. RsmD(YhhF) is necessary for methylation of G966 residue of 16S rRNA. Structure of Escherichia coli RsmD(YhhF) methyltransferase and the structure of the Methanococcus jannaschii RsmC ortholog were determined. All ribosomal guanine-(N2)-methyltransferases have similar AdoMet-binding sites. In relation to the ribosomal substrate recognition, two enzymes that recognize assembled subunits are relatively small single domain proteins and two enzymes that recognize naked rRNA are larger proteins containing separate methyltransferase- and RNA-binding domains. The model for recognition of specific target nucleotide is proposed. The hypothetical role of the m(2)G residues in rRNA is discussed.
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53
Total citations:
53
Citations from 2025:
3
(5.66%)
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GOST
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Sergiev P. V. et al. Ribosomal RNA guanine-(N2)-methyltransferases and their targets // Nucleic Acids Research. 2007. Vol. 35. No. 7. pp. 2295-2301.
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Sergiev P. V., Bogdanov A. A., Dontsova O. A. Ribosomal RNA guanine-(N2)-methyltransferases and their targets // Nucleic Acids Research. 2007. Vol. 35. No. 7. pp. 2295-2301.
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RIS
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TY - JOUR
DO - 10.1093/nar/gkm104
UR - https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkm104
TI - Ribosomal RNA guanine-(N2)-methyltransferases and their targets
T2 - Nucleic Acids Research
AU - Sergiev, Petr V.
AU - Bogdanov, Alexey A.
AU - Dontsova, Olga A.
PY - 2007
DA - 2007/03/27
PB - Oxford University Press
SP - 2295-2301
IS - 7
VL - 35
PMID - 17389639
SN - 0305-1048
SN - 1362-4962
ER -
Cite this
BibTex (up to 50 authors)
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@article{2007_Sergiev,
author = {Petr V. Sergiev and Alexey A. Bogdanov and Olga A. Dontsova},
title = {Ribosomal RNA guanine-(N2)-methyltransferases and their targets},
journal = {Nucleic Acids Research},
year = {2007},
volume = {35},
publisher = {Oxford University Press},
month = {mar},
url = {https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkm104},
number = {7},
pages = {2295--2301},
doi = {10.1093/nar/gkm104}
}
Cite this
MLA
Copy
Sergiev, Petr V., et al. “Ribosomal RNA guanine-(N2)-methyltransferases and their targets.” Nucleic Acids Research, vol. 35, no. 7, Mar. 2007, pp. 2295-2301. https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkm104.
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