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Science

, volume 337 , issue 6093 , pages 473-476

The Structure and Catalytic Cycle of a Sodium-Pumping Pyrophosphatase

Juho Kellosalo ^{1, 2}

Tommi Kajander ¹

KONSTANTIN KOGAN ¹

Kisun Pokharel ^{1, 3}

Adrian Goldman ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

Structural Biology and Biophysics Program, Institute of Biotechnology, Post Office Box 65, University of Helsinki, FIN-00014, Finland. |

Graduate School of Informational and Structural Biology, Finland. |

Department of Biochemistry and Food Chemistry, FIN-20014 University of Turku, Finland. |

Publication type: Journal Article

Publication date: 2012-07-27

American Association for the Advancement of Science (AAAS)

Science

scimago Q1

wos Q1

SJR: 10.416

CiteScore: 48.4

Impact factor: 45.8

ISSN: 00368075, 10959203

DOI: 10.1126/science.1222505

Copy DOI

PubMed ID: 22837527

Multidisciplinary

Abstract

View of a Sodium Pump

Membrane-integral pyrophosphatases (M-PPases) found in plants, protozoans, bacteria, and archaea, link pyrophosphate hydrolysis or synthesis to sodium or proton pumping and contribute to generating an electrochemical potential across the membrane. Kellosalo et al. (p. 473 ) report the structure of the sodium pumping M-PPase from Thermotoga maritima in the resting state with product bound. The structures reveal the conformational changes that are likely to accompany pyrophosphate binding and provide insight into the ion-pumping mechanism.

Found

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Zvereva Maria

DSc in Chemistry, professor

102 publications, 1 295 citations

h-index: 19

Lomonosov Moscow State University

1 citation

Le-Deygen Irina

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PhD in Chemistry

68 publications, 2 744 citations, 8 reviews

h-index: 19

Lomonosov Moscow State University

Research interests

Antibiotics

Chitosan

Drug delivery systems

Polymers for drug delivery

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GOST |

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GOST Copy

Kellosalo J. et al. The Structure and Catalytic Cycle of a Sodium-Pumping Pyrophosphatase // Science. 2012. Vol. 337. No. 6093. pp. 473-476.

GOST all authors (up to 50) Copy

Kellosalo J., Kajander T., KOGAN K., Pokharel K., Goldman A. The Structure and Catalytic Cycle of a Sodium-Pumping Pyrophosphatase // Science. 2012. Vol. 337. No. 6093. pp. 473-476.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1126/science.1222505

UR - https://doi.org/10.1126/science.1222505

TI - The Structure and Catalytic Cycle of a Sodium-Pumping Pyrophosphatase

T2 - Science

AU - Kellosalo, Juho

AU - Kajander, Tommi

AU - KOGAN, KONSTANTIN

AU - Pokharel, Kisun

AU - Goldman, Adrian

PY - 2012

DA - 2012/07/27

PB - American Association for the Advancement of Science (AAAS)

SP - 473-476

IS - 6093

VL - 337

PMID - 22837527

SN - 0036-8075

SN - 1095-9203

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2012_Kellosalo,

author = {Juho Kellosalo and Tommi Kajander and KONSTANTIN KOGAN and Kisun Pokharel and Adrian Goldman},

title = {The Structure and Catalytic Cycle of a Sodium-Pumping Pyrophosphatase},

journal = {Science},

year = {2012},

volume = {337},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {jul},

url = {https://doi.org/10.1126/science.1222505},

number = {6093},

pages = {473--476},

doi = {10.1126/science.1222505}

}

MLA

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MLA Copy

Kellosalo, Juho, et al. “The Structure and Catalytic Cycle of a Sodium-Pumping Pyrophosphatase.” Science, vol. 337, no. 6093, Jul. 2012, pp. 473-476. https://doi.org/10.1126/science.1222505.

Publisher

American Association for the Advancement of Science (AAAS)

Journal

Science

scimago Q1

wos Q1

SJR

10.416

CiteScore

48.4

Impact factor

45.8

ISSN

00368075 (Print)

10959203 (Electronic)