Mutations in Three Distinct Loci Cause Resistance to Peptide Deformylase Inhibitors in Bacillus subtilis
Тип публикации: Journal Article
Дата публикации: 2009-04-09
SCImago Q1
Tоп 10% SCImago
WOS Q1
БС1
SJR: 1.473
CiteScore: 8.4
Impact factor: 4.5
ISSN: 00664804, 10986596
PubMed ID:
19171795
Pharmacology
Infectious Diseases
Pharmacology (medical)
Краткое описание
ABSTRACT
Bacillus subtilis mutants with resistance against peptide deformylase inhibitors were isolated. All showed a bypass of the pathway through mutations in three genes required for formylation of Met-tRNA fMet , fmt, folD , and glyA. glyA corresponds to a yet uncharacterized locus inducing resistance. The bypass of formylation caused robust fitness reduction but was not accompanied by alterations of the transcription profile. A subtle adaptation of the enzymes of the intermediary metabolism was observed.
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ГОСТ
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Duroc Y., Giglione C., Meinnel T. Mutations in Three Distinct Loci Cause Resistance to Peptide Deformylase Inhibitors in Bacillus subtilis // Antimicrobial Agents and Chemotherapy. 2009. Vol. 53. No. 4. pp. 1673-1678.
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Duroc Y., Giglione C., Meinnel T. Mutations in Three Distinct Loci Cause Resistance to Peptide Deformylase Inhibitors in Bacillus subtilis // Antimicrobial Agents and Chemotherapy. 2009. Vol. 53. No. 4. pp. 1673-1678.
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TY - JOUR
DO - 10.1128/aac.01340-08
UR - https://doi.org/10.1128/aac.01340-08
TI - Mutations in Three Distinct Loci Cause Resistance to Peptide Deformylase Inhibitors in Bacillus subtilis
T2 - Antimicrobial Agents and Chemotherapy
AU - Duroc, Yann
AU - Giglione, Carmela
AU - Meinnel, Thierry
PY - 2009
DA - 2009/04/09
PB - American Society for Microbiology
SP - 1673-1678
IS - 4
VL - 53
PMID - 19171795
SN - 0066-4804
SN - 1098-6596
ER -
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@article{2009_Duroc,
author = {Yann Duroc and Carmela Giglione and Thierry Meinnel},
title = {Mutations in Three Distinct Loci Cause Resistance to Peptide Deformylase Inhibitors in Bacillus subtilis},
journal = {Antimicrobial Agents and Chemotherapy},
year = {2009},
volume = {53},
publisher = {American Society for Microbiology},
month = {apr},
url = {https://doi.org/10.1128/aac.01340-08},
number = {4},
pages = {1673--1678},
doi = {10.1128/aac.01340-08}
}
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MLA
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Duroc, Yann, et al. “Mutations in Three Distinct Loci Cause Resistance to Peptide Deformylase Inhibitors in Bacillus subtilis.” Antimicrobial Agents and Chemotherapy, vol. 53, no. 4, Apr. 2009, pp. 1673-1678. https://doi.org/10.1128/aac.01340-08.
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