Biochemistry (Moscow), volume 82, issue 11, pages 1391-1401
Protein poly(ADP-ribosyl)ation system: Changes in development and aging as well as due to restriction of cell proliferation
Publication type: Journal Article
Publication date: 2017-11-11
Journal:
Biochemistry (Moscow)
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 2.8
ISSN: 00062979, 16083040
Biochemistry
General Medicine
Abstract
It is well known that the number of dividing cells in an organism decreases with age. The average rate of cell division in tissues and organs of a mature organism sharply decreases, which is probably a trigger for accumulation of damage leading to disturbance of genome integrity. This can be a cause for the development of many age-related diseases and appearance of phenotypic and physiological signs of aging. In this connection, the protein poly(ADP-ribosyl)ation system, which is activated in response to appearance of various DNA damage, attracts great interest. This review summarizes and analyzes data on changes in the poly(ADP-ribosyl)ation system during development and aging in vivo and in vitro, and due to restriction of cell proliferation. Special attention is given to methodological aspects of determination of activity of poly(ADP-ribose) polymerases (PARPs). Analysis of relevant publications and our own data has led us to the conclusion that PARP activity upon the addition of free DNA ends (in this review referred to as stimulated PARP activity) is steadily decreasing with age. However, the dynamics of PARP activity measured without additional activation of the enzyme (in this review referred to as unstimulated activity) does not have such a clear trend: in many studies, the presented differences are statistically non-significant, although it is well known that the number of unrepaired DNA lesions steadily increases with aging. Apparently, the cell has additional regulatory systems that limit its own capability of reacting to DNA damage. Special attention is given to the influence of the cell proliferative status on PARP activity. We have systematized and analyzed data on changes in PARP activity during development and aging of an organism, as well as data on differences in the dynamics of this activity in the presence/absence of additional stimulation and on cellular processes that are associated with activation of these enzymes. Moreover, data obtained in different models of cellular aging are compared.
Citations by journals
|
1
2
|
|
|
Biochemistry (Moscow)
|
Biochemistry (Moscow)
2 publications, 33.33%
|
|
Moscow University Biological Sciences Bulletin
|
Moscow University Biological Sciences Bulletin
1 publication, 16.67%
|
|
Molecular Biology Reports
|
Molecular Biology Reports
1 publication, 16.67%
|
|
Oxidative Medicine and Cellular Longevity
|
Oxidative Medicine and Cellular Longevity
1 publication, 16.67%
|
|
Advances in Gerontology
|
Advances in Gerontology
1 publication, 16.67%
|
|
1
2
|
Citations by publishers
|
1
2
3
4
|
|
|
Pleiades Publishing
|
Pleiades Publishing
4 publications, 66.67%
|
|
Springer Nature
|
Springer Nature
1 publication, 16.67%
|
|
Hindawi Limited
|
Hindawi Limited
1 publication, 16.67%
|
|
1
2
3
4
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2018,2019,2020,2021,2022,2023,2024],"ids":[0,0,0,0,0,0,0],"codes":[0,0,0,0,0,0,0],"imageUrls":["","","","","","",""],"datasets":[{"label":"Citations number","data":[1,1,1,0,0,1,2],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["16.67","16.67","16.67",0,0,"16.67","33.33"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Biochemistry (Moscow)","Moscow University Biological Sciences Bulletin","Molecular Biology Reports","Oxidative Medicine and Cellular Longevity","Advances in Gerontology"],"ids":[2119,12722,2791,11615,9266],"codes":[0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/hqfzhQAjTGlNSRs6yzFNITgjSMm9Jr2QuotJHIvE_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp"],"datasets":[{"label":"","data":[2,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[33.33,16.67,16.67,16.67,16.67],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Pleiades Publishing","Springer Nature","Hindawi Limited"],"ids":[101,8,6921],"codes":[0,0,0],"imageUrls":["\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/hqfzhQAjTGlNSRs6yzFNITgjSMm9Jr2QuotJHIvE_medium.webp"],"datasets":[{"label":"","data":[4,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6"],"percentage":[66.67,16.67,16.67],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Shilovsky G. A. et al. Protein poly(ADP-ribosyl)ation system: Changes in development and aging as well as due to restriction of cell proliferation // Biochemistry (Moscow). 2017. Vol. 82. No. 11. pp. 1391-1401.
GOST all authors (up to 50)
Copy
Shilovsky G. A., Shram S., Morgunova G. V., Khokhlov A. N. Protein poly(ADP-ribosyl)ation system: Changes in development and aging as well as due to restriction of cell proliferation // Biochemistry (Moscow). 2017. Vol. 82. No. 11. pp. 1391-1401.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1134/S0006297917110177
UR - https://doi.org/10.1134%2FS0006297917110177
TI - Protein poly(ADP-ribosyl)ation system: Changes in development and aging as well as due to restriction of cell proliferation
T2 - Biochemistry (Moscow)
AU - Shilovsky, G A
AU - Shram, S.I.
AU - Morgunova, G V
AU - Khokhlov, A N
PY - 2017
DA - 2017/11/11 00:00:00
PB - Pleiades Publishing
SP - 1391-1401
IS - 11
VL - 82
SN - 0006-2979
SN - 1608-3040
ER -
Cite this
BibTex
Copy
@article{2017_Shilovsky,
author = {G A Shilovsky and S.I. Shram and G V Morgunova and A N Khokhlov},
title = {Protein poly(ADP-ribosyl)ation system: Changes in development and aging as well as due to restriction of cell proliferation},
journal = {Biochemistry (Moscow)},
year = {2017},
volume = {82},
publisher = {Pleiades Publishing},
month = {nov},
url = {https://doi.org/10.1134%2FS0006297917110177},
number = {11},
pages = {1391--1401},
doi = {10.1134/S0006297917110177}
}
Cite this
MLA
Copy
Shilovsky, G. A., et al. “Protein poly(ADP-ribosyl)ation system: Changes in development and aging as well as due to restriction of cell proliferation.” Biochemistry (Moscow), vol. 82, no. 11, Nov. 2017, pp. 1391-1401. https://doi.org/10.1134%2FS0006297917110177.
Profiles