Mononuclear Cu(II), Zn(II), and Co(II) Complexes with 2-Furoate Anions and 2,2'-Bpy: Synthesis, Structure, and Biological Activity

The mononuclear complexes [M(Fur)2(Bpy)(H2O)] (M = Cu (I), Zn (II)) were prepared by the reactions of copper(II) and zinc(II) acetates with 2-furoic acid (HFur) anion and 2,2'-bipyridine (Bpy) in acetonitrile. A similar reaction with ZnCl2 used instead of Zn(OAc)2 · 2H2O gave the complex [Zn(Fur)2(Bpy)] (III). The cobalt(II) complex [Co(Fur)2(Bpy)] (IV) was obtained by the reaction of cobalt trimethylacetate with HFur and Bpy. The structure of mononuclear complexes was determined by X-ray diffraction (CIF files CCDC nos. 1993168 (I), 1993169 (II), 1993170 (III), and 1993171 (IV)). Compounds I, III, and IV were studied for the biological activity in vitro against the nonpathogenic mycobacterial strain Mycolicibacterium smegmatis. It was found that I and III have high biological activity and are promising for further studies for antituberculosis activity.