Laboratory of Chemistry of Coordinating Polynuclear Compounds

Synthesized compounds are complexes based on vital metals (Cu, Zn, Mn, Co, Fe, etc.) with anions of 2-furancarboxylic acid and various donor ligands - phenanthroline, bipyridine, phenylpyridine, pyridine, etc. The activity of the complexes is determined relative to drugs of the 1st series of tuberculosis treatment (isoniazid and rifampicin). Stage 1 of determination - a complex is applied to the discs and placed in the medium of the strain, and then, as cloudy or transparent discs form, the concentration is determined., the so-called MIC (minimum inhibitory concentration) is the effective concentration at which the colony dies. Complexes with high activity are further determined for cytotoxicity and are already being put into clinical trials to create pharmaceutical compositions of future anti-tuberculosis drugs.

Synthesis of heterometallic coordination compounds with various combinations of metal ions (s-d, d-d' and d-f) by varying the geometric and electronic characteristics of malonate ligands. Investigation of the structure-forming role of a substituent in carboxylate anions binding metal centers and determination of other factors affecting the crystal structure and magnetic properties of the compounds formed.