Russian Journal of Organic Chemistry

, volume 54 , issue 9 , pages 1411-1418

Synthesis and Biological Activity of Cyanoethyl Derivatives of Fusidic Acid

E V Salimova ¹

A G Mamaev ¹

E V Tretyakova ¹

O S Kukovinets ²

A R Mavzyutov ³

K Yu Shvets ^{2, 3}

L V Parfenova ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, Ufa, Russia |

Bashkir State University, Ufa, Russia |

Bashkir State Medical University, Ufa, Russia |

Publication type: Journal Article

Publication date: 2018-09-01

Pleiades Publishing

Russian Journal of Organic Chemistry

scimago Q4

wos Q4

SJR: 0.190

CiteScore: 1.3

Impact factor: 0.9

ISSN: 10704280, 16083393

DOI: 10.1134/S1070428018090245

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Organic Chemistry

Abstract

3,11-Dihydroxy and 3,11-dioxo triterpenoids of the fusidane series reacted with acrylonitrile in 1,4-dioxane in the presence of alkali and phase-transfer catalyst to give mono- and bis(2-cyanoethoxy) and 2-cyanoethyl derivatives. The reaction with 3,11-dioxo analog afforded 2,2-disubstituted derivative as a result of addition of two cyanoethyl groups to the α-position with respect to the C3=O carbonyl group. The isolated compounds were screened for antibacterial and antifungal activities.

Found

11 citations

Parfenova Lyudmila

🥼 🤝

DSc in Chemistry, associate professor

109 publications, 1 037 citations, 8 reviews

h-index: 17

Institute of Petrochemistry and Catalysis of the Ufa Federal Research Center of the Russian Academy of Sciences

Research interests

Asymmetric metal complex catalysis

Regenerative materials

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Salimova E. V. et al. Synthesis and Biological Activity of Cyanoethyl Derivatives of Fusidic Acid // Russian Journal of Organic Chemistry. 2018. Vol. 54. No. 9. pp. 1411-1418.

GOST all authors (up to 50) Copy

Salimova E. V., Mamaev A. G., Tretyakova E. V., Kukovinets O. S., Mavzyutov A. R., Shvets K. Yu., Parfenova L. V. Synthesis and Biological Activity of Cyanoethyl Derivatives of Fusidic Acid // Russian Journal of Organic Chemistry. 2018. Vol. 54. No. 9. pp. 1411-1418.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1134/S1070428018090245

UR - https://doi.org/10.1134/S1070428018090245

TI - Synthesis and Biological Activity of Cyanoethyl Derivatives of Fusidic Acid

T2 - Russian Journal of Organic Chemistry

AU - Salimova, E V

AU - Mamaev, A G

AU - Tretyakova, E V

AU - Kukovinets, O S

AU - Mavzyutov, A R

AU - Shvets, K Yu

AU - Parfenova, L V

PY - 2018

DA - 2018/09/01

PB - Pleiades Publishing

SP - 1411-1418

IS - 9

VL - 54

SN - 1070-4280

SN - 1608-3393

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2018_Salimova,

author = {E V Salimova and A G Mamaev and E V Tretyakova and O S Kukovinets and A R Mavzyutov and K Yu Shvets and L V Parfenova},

title = {Synthesis and Biological Activity of Cyanoethyl Derivatives of Fusidic Acid},

journal = {Russian Journal of Organic Chemistry},

year = {2018},

volume = {54},

publisher = {Pleiades Publishing},

month = {sep},

url = {https://doi.org/10.1134/S1070428018090245},

number = {9},

pages = {1411--1418},

doi = {10.1134/S1070428018090245}

}

MLA

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MLA Copy

Salimova, E. V., et al. “Synthesis and Biological Activity of Cyanoethyl Derivatives of Fusidic Acid.” Russian Journal of Organic Chemistry, vol. 54, no. 9, Sep. 2018, pp. 1411-1418. https://doi.org/10.1134/S1070428018090245.