Russian Journal of Organic Chemistry

, том 54 , издание 9 , страницы 1411-1418

Synthesis and Biological Activity of Cyanoethyl Derivatives of Fusidic Acid

Тип публикации: Journal Article

Дата публикации: 2018-09-01

Pleiades Publishing

Russian Journal of Organic Chemistry

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SJR: 0.190

CiteScore: 1.3

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ISSN: 10704280, 16083393

DOI: 10.1134/S1070428018090245

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Organic Chemistry

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3,11-Dihydroxy and 3,11-dioxo triterpenoids of the fusidane series reacted with acrylonitrile in 1,4-dioxane in the presence of alkali and phase-transfer catalyst to give mono- and bis(2-cyanoethoxy) and 2-cyanoethyl derivatives. The reaction with 3,11-dioxo analog afforded 2,2-disubstituted derivative as a result of addition of two cyanoethyl groups to the α-position with respect to the C3=O carbonyl group. The isolated compounds were screened for antibacterial and antifungal activities.

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Парфенова Людмила

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Salimova E. V. et al. Synthesis and Biological Activity of Cyanoethyl Derivatives of Fusidic Acid // Russian Journal of Organic Chemistry. 2018. Vol. 54. No. 9. pp. 1411-1418.

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Salimova E. V., Mamaev A. G., Tretyakova E. V., Kukovinets O. S., Mavzyutov A. R., Shvets K. Yu., Parfenova L. V. Synthesis and Biological Activity of Cyanoethyl Derivatives of Fusidic Acid // Russian Journal of Organic Chemistry. 2018. Vol. 54. No. 9. pp. 1411-1418.

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TY - JOUR

DO - 10.1134/S1070428018090245

UR - https://doi.org/10.1134/S1070428018090245

TI - Synthesis and Biological Activity of Cyanoethyl Derivatives of Fusidic Acid

T2 - Russian Journal of Organic Chemistry

AU - Salimova, E V

AU - Mamaev, A G

AU - Tretyakova, E V

AU - Kukovinets, O S

AU - Mavzyutov, A R

AU - Shvets, K Yu

AU - Parfenova, L V

PY - 2018

DA - 2018/09/01

PB - Pleiades Publishing

SP - 1411-1418

IS - 9

VL - 54

SN - 1070-4280

SN - 1608-3393

ER -

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@article{2018_Salimova,

author = {E V Salimova and A G Mamaev and E V Tretyakova and O S Kukovinets and A R Mavzyutov and K Yu Shvets and L V Parfenova},

title = {Synthesis and Biological Activity of Cyanoethyl Derivatives of Fusidic Acid},

journal = {Russian Journal of Organic Chemistry},

year = {2018},

volume = {54},

publisher = {Pleiades Publishing},

month = {sep},

url = {https://doi.org/10.1134/S1070428018090245},

number = {9},

pages = {1411--1418},

doi = {10.1134/S1070428018090245}

}

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Salimova, E. V., et al. “Synthesis and Biological Activity of Cyanoethyl Derivatives of Fusidic Acid.” Russian Journal of Organic Chemistry, vol. 54, no. 9, Sep. 2018, pp. 1411-1418. https://doi.org/10.1134/S1070428018090245.