Cell and Tissue Biology, volume 13, issue 3, pages 237-241
The Role of Mechanical Properties of the Nucleus in Maintaining Tissue Homeostasis
Lavrushkina S V
1
,
Ovsyannikova N L
2
,
Yudina A. S.
2
,
Strelkova O S
3
,
Zhironkina O A
3
,
Perepelina K I
4, 5
,
Malashicheva A B
4, 5
,
Kireev I I
1, 3, 6
Publication type: Journal Article
Publication date: 2019-05-01
Journal:
Cell and Tissue Biology
Quartile SCImago
Q4
Quartile WOS
—
Impact factor: —
ISSN: 1990519X, 19905203
Cell Biology
Abstract
Abstract —The rigid skeleton formed by networks of A- and B-type lamins is responsible for maintaining the nucleus shape. Moreover, the change in the ratio of lamin proteins in its composition, apparently, is a key factor determining mechanical properties of the cell nucleus, in particular plasticity. In this paper, the effect of the component composition of the nuclear lamina on the resistance of cells to mechanical stress and on the cell motility was considered. Expression of mutant forms of lamin A is accompanied by changes in the distance between microdomains of lamins within the nuclear membrane, and its increased bubbling relative to wild-type cells and cells overexpressing lamin A is observed. An increased number of deformed nuclei are noted when exposed to osmotic shock. The assessment of the effect of a change in the molecular composition of the nuclear lamina due to an increase (decrease) in expression of lamin A, as well as the introduction of progerin in an experimental wound model, showed that there are no differences under conditions of unlimited space.
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Journal of Biomechanical Engineering
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Journal of Biomechanical Engineering
1 publication, 100%
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Citations by publishers
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ASME
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ASME
1 publication, 100%
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Lavrushkina S. V. et al. The Role of Mechanical Properties of the Nucleus in Maintaining Tissue Homeostasis // Cell and Tissue Biology. 2019. Vol. 13. No. 3. pp. 237-241.
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Lavrushkina S. V., Ovsyannikova N. L., Yudina A. S., Strelkova O. S., Zhironkina O. A., Perepelina K. I., Malashicheva A. B., Kireev I. I. The Role of Mechanical Properties of the Nucleus in Maintaining Tissue Homeostasis // Cell and Tissue Biology. 2019. Vol. 13. No. 3. pp. 237-241.
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TY - JOUR
DO - 10.1134/S1990519X19030064
UR - https://doi.org/10.1134%2FS1990519X19030064
TI - The Role of Mechanical Properties of the Nucleus in Maintaining Tissue Homeostasis
T2 - Cell and Tissue Biology
AU - Lavrushkina, S V
AU - Perepelina, K I
AU - Malashicheva, A B
AU - Strelkova, O S
AU - Zhironkina, O A
AU - Kireev, I I
AU - Ovsyannikova, N L
AU - Yudina, A. S.
PY - 2019
DA - 2019/05/01 00:00:00
PB - Pleiades Publishing
SP - 237-241
IS - 3
VL - 13
SN - 1990-519X
SN - 1990-5203
ER -
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@article{2019_Lavrushkina,
author = {S V Lavrushkina and K I Perepelina and A B Malashicheva and O S Strelkova and O A Zhironkina and I I Kireev and N L Ovsyannikova and A. S. Yudina},
title = {The Role of Mechanical Properties of the Nucleus in Maintaining Tissue Homeostasis},
journal = {Cell and Tissue Biology},
year = {2019},
volume = {13},
publisher = {Pleiades Publishing},
month = {may},
url = {https://doi.org/10.1134%2FS1990519X19030064},
number = {3},
pages = {237--241},
doi = {10.1134/S1990519X19030064}
}
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Lavrushkina, S. V., et al. “The Role of Mechanical Properties of the Nucleus in Maintaining Tissue Homeostasis.” Cell and Tissue Biology, vol. 13, no. 3, May. 2019, pp. 237-241. https://doi.org/10.1134%2FS1990519X19030064.