Surface modification of Fe3O4 magnetic nanoparticles with (S)-naproxen

Fe3O4 magnetic nanoparticles (MNPs) were obtained using the gas condensation method. These MNPs were modified with 3-aminopropylsilane (APS) through covalent bonding. The methods of qualitative and quantitative analysis of the modified MNPs were developed using UV and IR spectroscopy and inductively coupled plasma emission spectrometry (ICP-ES). It was established that the maximum loading level of APS on the surface of Fe3O4 MNPs was 0.91 mmol/g MNP. The study of the activity of the surface amino groups of the nanocomposites was carried out by the example of their modification with (S)-naproxen. The optimum conditions for coupling reaction were found. It was shown that the reaction proceeded most efficiently when using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) as coupling agent in the presence of 1-hydroxy-1H-benzotriazole (HOBt). The maximum immobilization level of (S)-naproxen on the Fe3O4 MNP surface was 0.55 mmol/g MNP. Thus, the high reactivity of amino groups of the obtained nano-composites was shown, making it possible to further modify them.