volume 13 issue 1 pages 15-25

Conformation-dependent sequence design: Evolutionary approach

Publication typeJournal Article
Publication date2004-01-01
scimago Q3
wos Q3
SJR0.396
CiteScore3.7
Impact factor2.2
ISSN12928941, 1292895X
General Chemistry
Biophysics
Biotechnology
General Materials Science
Surfaces and Interfaces
Abstract
Abstract.A new modification of evolutionary approach to sequence design of copolymers has been proposed. A model of step-by-step evolution of a two-letter (HP) copolymer sequence has been studied by means of a coarse-grained Monte Carlo algorithm. The conditions for accepting a change in the primary sequence depend on the spatial conformation of HP-copolymer chain. This leads to a coupling between sequence and conformation and to formation of protein-like conformations and primary sequences (for some values of parameters of the model) independently of initial sequence and/or conformation. Simple theory describing these computer simulation observations is developed.
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GOST |
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GOST Copy
Chertovich A. V. et al. Conformation-dependent sequence design: Evolutionary approach // European Physical Journal E. 2004. Vol. 13. No. 1. pp. 15-25.
GOST all authors (up to 50) Copy
Chertovich A. V., Govorun E. N., Ivanov V. A., Khalatur P. G., Khokhlov A. R. Conformation-dependent sequence design: Evolutionary approach // European Physical Journal E. 2004. Vol. 13. No. 1. pp. 15-25.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1140/epje/e2004-00036-1
UR - https://doi.org/10.1140/epje/e2004-00036-1
TI - Conformation-dependent sequence design: Evolutionary approach
T2 - European Physical Journal E
AU - Chertovich, A V
AU - Govorun, E N
AU - Ivanov, V. A.
AU - Khalatur, P G
AU - Khokhlov, A R
PY - 2004
DA - 2004/01/01
PB - Springer Nature
SP - 15-25
IS - 1
VL - 13
PMID - 15024612
SN - 1292-8941
SN - 1292-895X
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2004_Chertovich,
author = {A V Chertovich and E N Govorun and V. A. Ivanov and P G Khalatur and A R Khokhlov},
title = {Conformation-dependent sequence design: Evolutionary approach},
journal = {European Physical Journal E},
year = {2004},
volume = {13},
publisher = {Springer Nature},
month = {jan},
url = {https://doi.org/10.1140/epje/e2004-00036-1},
number = {1},
pages = {15--25},
doi = {10.1140/epje/e2004-00036-1}
}
MLA
Cite this
MLA Copy
Chertovich, A. V., et al. “Conformation-dependent sequence design: Evolutionary approach.” European Physical Journal E, vol. 13, no. 1, Jan. 2004, pp. 15-25. https://doi.org/10.1140/epje/e2004-00036-1.