Open Access

Journal of the American Heart Association

, том 9 , издание 7

Association of Insulin Resistance, Plasma Glucose Level, and Serum Insulin Level With Hypertension in a Population With Different Stages of Impaired Glucose Metabolism

Kanji yamada ¹

Ryoji Ozono ²

Yukihito Higashi ³

Ryo Maeda ¹

Yasuki Kihara ⁴

Скрыть аффилиации авторов Показать аффилиации авторов: 4 аффилиации

Health Management and Promotion Center Hiroshima Atomic Bomb Casualty Council Hiroshima Japan |

Department of General Medicine Hiroshima University Graduate School of Biomedical and Health Sciences Hiroshima Japan |

Department of Cardiovascular Regeneration and Medicine Research Institute for Radiation Biology and Medicine Hiroshima University Graduate School of Biomedical and Health Sciences Hiroshima Japan |

⁴

Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences Hiroshima Japan |

Тип публикации: Journal Article

Дата публикации: 2020-03-21

Wiley

Journal of the American Heart Association

scimago Q1

wos Q1

БС1

SJR: 2.189

CiteScore: 8.5

Impact factor: 5.3

ISSN: 20479980

DOI: 10.1161/JAHA.119.015546

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PubMed ID: 32200720

Cardiology and Cardiovascular Medicine

Краткое описание

Background

The interrelationships among the different stages of impaired glucose metabolism, insulin resistance, and hypertension are not fully understood.

Methods and Results

We investigated the impact of insulin resistance, plasma glucose, and serum immunoreactive insulin levels on hypertension in 19 166 participants with different stages of impaired glucose metabolism (7114 normal fasting glucose/normal glucose tolerance, 3543 isolated impaired fasting glucose [ IFG ], 2089 isolated impaired glucose tolerance, 2922 IFG plus impaired glucose tolerance, and 3498 diabetes mellitus]) determined by 75‐g oral glucose tolerance tests. Participants were recruited from examinees who finished a general health checkup for atomic bomb survivors between 1982 and 2017. The profiles of plasma glucose and immunoreactive insulin during oral glucose tolerance tests were assessed using the total area under the curve. Insulin resistance was assessed using the homeostasis model assessment of insulin resistance. The rate of hypertension increased from 36.3% in participants with normal fasting glucose/normal glucose tolerance to 50.1%, 50.8%, 58.3%, and 63.8% in participants with isolated IFG , isolated impaired glucose tolerance, IFG plus impaired glucose tolerance, and diabetes mellitus, respectively. Homeostasis model assessment of insulin resistance was associated with hypertension regardless of the presence and the degree of impaired glucose metabolism. Furthermore, fasting plasma glucose and serum immunoreactive insulin levels and areas under the curve for plasma glucose and immunoreactive insulin during oral glucose tolerance tests were associated with hypertension in normal fasting glucose/normal glucose tolerance and isolated IFG , but such a relationship was diminished in other types of prediabetes and diabetes mellitus.

Conclusions

The prevalence of hypertension increases with worsening stages of impaired glucose metabolism; however, hyperglycemia and hyperinsulinemia are significant contributors to the presence of hypertension only in the early stages of impaired insulin metabolism.

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yamada K. et al. Association of Insulin Resistance, Plasma Glucose Level, and Serum Insulin Level With Hypertension in a Population With Different Stages of Impaired Glucose Metabolism // Journal of the American Heart Association. 2020. Vol. 9. No. 7.

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yamada K., Ozono R., Higashi Y., Maeda R., Kihara Y. Association of Insulin Resistance, Plasma Glucose Level, and Serum Insulin Level With Hypertension in a Population With Different Stages of Impaired Glucose Metabolism // Journal of the American Heart Association. 2020. Vol. 9. No. 7.

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TY - JOUR

DO - 10.1161/JAHA.119.015546

UR - https://doi.org/10.1161/JAHA.119.015546

TI - Association of Insulin Resistance, Plasma Glucose Level, and Serum Insulin Level With Hypertension in a Population With Different Stages of Impaired Glucose Metabolism

T2 - Journal of the American Heart Association

AU - yamada, Kanji

AU - Ozono, Ryoji

AU - Higashi, Yukihito

AU - Maeda, Ryo

AU - Kihara, Yasuki

PY - 2020

DA - 2020/03/21

PB - Wiley

IS - 7

VL - 9

PMID - 32200720

SN - 2047-9980

ER -

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@article{2020_yamada,

author = {Kanji yamada and Ryoji Ozono and Yukihito Higashi and Ryo Maeda and Yasuki Kihara},

title = {Association of Insulin Resistance, Plasma Glucose Level, and Serum Insulin Level With Hypertension in a Population With Different Stages of Impaired Glucose Metabolism},

journal = {Journal of the American Heart Association},

year = {2020},

volume = {9},

publisher = {Wiley},

month = {mar},

url = {https://doi.org/10.1161/JAHA.119.015546},

number = {7},

doi = {10.1161/JAHA.119.015546}

}

Издатель

Wiley

Журнал

Journal of the American Heart Association

scimago Q1

wos Q1

БС1

SJR

2.189

CiteScore

8.5

Impact factor

5.3

ISSN

20479980 (Print, Electronic)