Open Access
Journal of Inflammation Research, volume Volume 11, pages 431-445
Sex differences of inflammation in target organs, induced by intraperitoneal injection of lipopolysaccharide, depend on its dose
Kosyreva Anna
1
,
Makarova O.
2
,
Kakturskiy Lev V
3
,
Mikhailova L P
2
,
Boltovskaya Marina N
4
,
Rogov Konstantin A
3
Publication type: Journal Article
Publication date: 2018-11-08
Journal:
Journal of Inflammation Research
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 4.5
ISSN: 11787031
PubMed ID:
30519071
Immunology
Immunology and Allergy
Abstract
Purpose The aim of our research was to study sex differences and the severity of inflammatory changes in target organs and the peculiarities of immunological disorders when low and high doses of lipopolysaccharide (LPS) were administered to rats. Methods Male and female 2- to 3-month-old Wistar rats (200–250 g) were injected intraperitoneally with Escherichia coli LPS in one of two doses: 1.5 or 15 mg/kg. In a day after the LPS injection, we studied endotoxin, corticosterone, sex steroids, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) activity levels in the serum; morphological disorders in the lung, liver, thymus, and spleen; ex vivo production of IL-2, IL-4, tumor necrosis factor (TNF), and interferon γ (IFNγ) by splenic cells activated by ConA; and relative amount of T- and B-lymphocytes in the peripheral blood. Results After the injection of low-dose LPS, the serum endotoxin level increased only in males and was combined with a more pronounced inflammatory response in the lungs and thymus and an increase in ALT and AST activity levels without any changes in corticosterone level. After the injection of high-dose LPS, the inflammatory and pathological changes in the target organs manifested as severe endotoxemia and sex differences of pathological changes in the lungs and liver were not revealed. The level of production of IL-2, IL-4, IFNγ, and TNF by splenic cells and the number of T-lymphocytes, including cytotoxic cells, in the peripheral blood, decreased in males, which is an evidence of a pronounced suppression of the immune response. Conclusion We have shown that the morphofunctional changes in the organs of the immune system in females and males, as well as the intensity of the sex differences of inflammation, depend on the severity of systemic inflammatory response, induced by different doses of LPS.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Kosyreva A. et al. Sex differences of inflammation in target organs, induced by intraperitoneal injection of lipopolysaccharide, depend on its dose // Journal of Inflammation Research. 2018. Vol. Volume 11. pp. 431-445.
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Kosyreva A., Makarova O., Kakturskiy L. V., Mikhailova L. P., Boltovskaya M. N., Rogov K. A. Sex differences of inflammation in target organs, induced by intraperitoneal injection of lipopolysaccharide, depend on its dose // Journal of Inflammation Research. 2018. Vol. Volume 11. pp. 431-445.
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TY - JOUR
DO - 10.2147/JIR.S178288
UR - https://doi.org/10.2147%2FJIR.S178288
TI - Sex differences of inflammation in target organs, induced by intraperitoneal injection of lipopolysaccharide, depend on its dose
T2 - Journal of Inflammation Research
AU - Kosyreva, Anna
AU - Makarova, O.
AU - Kakturskiy, Lev V
AU - Mikhailova, L P
AU - Boltovskaya, Marina N
AU - Rogov, Konstantin A
PY - 2018
DA - 2018/11/08 00:00:00
PB - Dove Medical Press
SP - 431-445
VL - Volume 11
PMID - 30519071
SN - 1178-7031
ER -
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@article{2018_Kosyreva,
author = {Anna Kosyreva and O. Makarova and Lev V Kakturskiy and L P Mikhailova and Marina N Boltovskaya and Konstantin A Rogov},
title = {Sex differences of inflammation in target organs, induced by intraperitoneal injection of lipopolysaccharide, depend on its dose},
journal = {Journal of Inflammation Research},
year = {2018},
volume = {Volume 11},
publisher = {Dove Medical Press},
month = {nov},
url = {https://doi.org/10.2147%2FJIR.S178288},
pages = {431--445},
doi = {10.2147/JIR.S178288}
}