Ventilator-associated pneumonia in neonates and children: a systematic analysis of diagnostic methods and prevention
Aim: While ventilator-associated pneumonia (VAP) remains frequent in Pediatric ICU, there is no gold standard for diagnosis. Methodology: We conducted a systematic PUBMED analysis (January 1990–January 2017) searching original, full-length studies addressing only pediatric patients; for VAP diagnosis, only those comparing different diagnostic methods and for VAP prevention those implementing preventive measures. Results: Among 367 articles, 17 and 16 were analyzed for diagnosis and prevention, respectively. For diagnosis, 13 studies used CDC criteria; whereas, 14 assessed algorithms: clinical pulmonary index score, ventilator-associated events and biomarkers. Among five randomized trials assessing preventive strategies one found a role of probiotics. Ventilator-care bundles reduced VAP rates. Conclusion: Absence of diagnostic gold standard impedes comparison of current approaches and preventive strategies.
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Pediatric Infectious Disease Journal
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Antibiotics
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Children
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BMC Infectious Diseases
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Cochrane Database of Systematic Reviews
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Infection Control and Hospital Epidemiology
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Journal of Pediatric Critical Care
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Pathogens
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AAP Grand Rounds
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Experimental and Therapeutic Medicine
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Pediatric Critical Care Medicine
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Infectious Diseases & Immunity
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International Journal of Environmental Research and Public Health
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Frontiers in Pediatrics
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Frontiers in Medicine
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Der Gynakologe
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Journal of Perinatology
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BMC Pediatrics
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Pediatric Research
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Acta Biomaterialia
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Seminars in Perinatology
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Environmental Health: A Global Access Science Source
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Pediatrics and Neonatology
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BioFactors
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All Life
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Revista Romana de Medicina de Laborator
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Journal of Healthcare Engineering
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Hospital pediatrics
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Pediatric Pulmonology
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Springer Nature
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MDPI
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Elsevier
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Ovid Technologies (Wolters Kluwer Health)
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Wiley
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Frontiers Media S.A.
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American Academy of Pediatrics
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Cambridge University Press
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Spandidos Publications
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Taylor & Francis
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De Gruyter Brill
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Hindawi Limited
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AIP Publishing
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SAGE
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
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