Mechanism of Metallo-β-Lactamase Inhibition by Oxacephalosporin Antibiotic
Publication type: Journal Article
Publication date: 2018-07-01
scimago Q4
wos Q4
SJR: 0.153
CiteScore: 1.1
Impact factor: 0.5
ISSN: 00271314, 19350260
General Chemistry
Abstract
Metallo-β-lactamases is a family of bacterial zinc-dependent enzymes that hydrolyze β-lactam antibiotics and are responsible for the bacterial resistance to them. As a result of the reaction, the slowly hydrolyzed substrate moxalactam undergoes not only chemical transformations in the structure of the β-lactam ring but a negatively charged fragment is also released on the periphery of the molecule, resulting in the formation of an intermediate firmly bound to the active site. In the paper, we present the results of the calculations of the mechanism of this process by a combined quantum mechanics/molecular mechanics approach.
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Khrenova M. G. et al. Mechanism of Metallo-β-Lactamase Inhibition by Oxacephalosporin Antibiotic // Moscow University Chemistry Bulletin. 2018. Vol. 73. No. 4. pp. 155-157.
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Khrenova M. G., Kulakova A. M., Grigorenko B. L., Nemukhin A. V. Mechanism of Metallo-β-Lactamase Inhibition by Oxacephalosporin Antibiotic // Moscow University Chemistry Bulletin. 2018. Vol. 73. No. 4. pp. 155-157.
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TY - JOUR
DO - 10.3103/S002713141804003X
UR - http://link.springer.com/10.3103/S002713141804003X
TI - Mechanism of Metallo-β-Lactamase Inhibition by Oxacephalosporin Antibiotic
T2 - Moscow University Chemistry Bulletin
AU - Khrenova, M. G.
AU - Kulakova, A M
AU - Grigorenko, B. L.
AU - Nemukhin, A. V.
PY - 2018
DA - 2018/07/01
PB - Allerton Press
SP - 155-157
IS - 4
VL - 73
SN - 0027-1314
SN - 1935-0260
ER -
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@article{2018_Khrenova,
author = {M. G. Khrenova and A M Kulakova and B. L. Grigorenko and A. V. Nemukhin},
title = {Mechanism of Metallo-β-Lactamase Inhibition by Oxacephalosporin Antibiotic},
journal = {Moscow University Chemistry Bulletin},
year = {2018},
volume = {73},
publisher = {Allerton Press},
month = {jul},
url = {http://link.springer.com/10.3103/S002713141804003X},
number = {4},
pages = {155--157},
doi = {10.3103/S002713141804003X}
}
Cite this
MLA
Copy
Khrenova, M. G., et al. “Mechanism of Metallo-β-Lactamase Inhibition by Oxacephalosporin Antibiotic.” Moscow University Chemistry Bulletin, vol. 73, no. 4, Jul. 2018, pp. 155-157. http://link.springer.com/10.3103/S002713141804003X.