Moscow University Chemistry Bulletin, volume 73, issue 4, pages 155-157

Mechanism of Metallo-β-Lactamase Inhibition by Oxacephalosporin Antibiotic

Publication typeJournal Article
Publication date2018-07-01
Quartile SCImago
Q4
Quartile WOS
Impact factor0.6
ISSN00271314, 19350260
General Chemistry
Abstract
Metallo-β-lactamases is a family of bacterial zinc-dependent enzymes that hydrolyze β-lactam antibiotics and are responsible for the bacterial resistance to them. As a result of the reaction, the slowly hydrolyzed substrate moxalactam undergoes not only chemical transformations in the structure of the β-lactam ring but a negatively charged fragment is also released on the periphery of the molecule, resulting in the formation of an intermediate firmly bound to the active site. In the paper, we present the results of the calculations of the mechanism of this process by a combined quantum mechanics/molecular mechanics approach.

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Khrenova M. G. et al. Mechanism of Metallo-β-Lactamase Inhibition by Oxacephalosporin Antibiotic // Moscow University Chemistry Bulletin. 2018. Vol. 73. No. 4. pp. 155-157.
GOST all authors (up to 50) Copy
Khrenova M. G., Kulakova A. M., Grigorenko B. L., Nemukhin A. V. Mechanism of Metallo-β-Lactamase Inhibition by Oxacephalosporin Antibiotic // Moscow University Chemistry Bulletin. 2018. Vol. 73. No. 4. pp. 155-157.
RIS |
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TY - JOUR
DO - 10.3103/S002713141804003X
UR - https://doi.org/10.3103%2FS002713141804003X
TI - Mechanism of Metallo-β-Lactamase Inhibition by Oxacephalosporin Antibiotic
T2 - Moscow University Chemistry Bulletin
AU - Khrenova, M. G.
AU - Kulakova, A M
AU - Nemukhin, A. V.
AU - Grigorenko, B. L.
PY - 2018
DA - 2018/07/01 00:00:00
PB - Pleiades Publishing
SP - 155-157
IS - 4
VL - 73
SN - 0027-1314
SN - 1935-0260
ER -
BibTex |
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BibTex Copy
@article{2018_Khrenova
author = {M. G. Khrenova and A M Kulakova and A. V. Nemukhin and B. L. Grigorenko},
title = {Mechanism of Metallo-β-Lactamase Inhibition by Oxacephalosporin Antibiotic},
journal = {Moscow University Chemistry Bulletin},
year = {2018},
volume = {73},
publisher = {Pleiades Publishing},
month = {jul},
url = {https://doi.org/10.3103%2FS002713141804003X},
number = {4},
pages = {155--157},
doi = {10.3103/S002713141804003X}
}
MLA
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MLA Copy
Khrenova, M. G., et al. “Mechanism of Metallo-β-Lactamase Inhibition by Oxacephalosporin Antibiotic.” Moscow University Chemistry Bulletin, vol. 73, no. 4, Jul. 2018, pp. 155-157. https://doi.org/10.3103%2FS002713141804003X.
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