Open Access
Preparation ofN,O-carboxymethyl chitosan nanoparticles as an insulin carrier
Тип публикации: Journal Article
Дата публикации: 2009-10-20
SCImago Q1
Tоп 10% SCImago
WOS Q1
БС1
SJR: 1.339
CiteScore: 20.2
Impact factor: 8
ISSN: 10717544, 15210464
PubMed ID:
19839790
General Medicine
Pharmaceutical Science
Краткое описание
The aim of this research was to develop pH-sensitive insulin-loaded NOCC (N,O-carboxymethyl chitosan) nanoparticles for the controlled release of insulin via the oral route. Thus, in this study, insulin-loaded NOCC nanoparticles were prepared by ionic gelation of NOCC with TPP (tripolyphosphate). NOCC nanoparticles were formed at conditions of 2 mg/ml of NOCC and 1 mg/ml of TPP. It was found that the encapsulation efficiency and process yield decreased with increasing NOCC to TPP weight ratio. Furthermore, the cumulative release of insulin from insulin-loaded NOCC nanoparticles decreased with decreasing NOCC-to-TPP weight ratio, but it increased with decreasing the initial concentration of insulin. The higher the pH of the phosphate buffered saline, the greater the amount of cumulative release of insulin-loaded NOCC nanoparticles, and thus they could protect insulin from acid.
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ГОСТ
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Lin C., Lin C. Preparation ofN,O-carboxymethyl chitosan nanoparticles as an insulin carrier // Drug Delivery. 2009. Vol. 16. No. 8. pp. 458-464.
ГОСТ со всеми авторами (до 50)
Скопировать
Lin C., Lin C. Preparation ofN,O-carboxymethyl chitosan nanoparticles as an insulin carrier // Drug Delivery. 2009. Vol. 16. No. 8. pp. 458-464.
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RIS
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TY - JOUR
DO - 10.3109/10717540903353090
UR - https://doi.org/10.3109/10717540903353090
TI - Preparation ofN,O-carboxymethyl chitosan nanoparticles as an insulin carrier
T2 - Drug Delivery
AU - Lin, Chuen-Chang
AU - Lin, Cheng-Wei
PY - 2009
DA - 2009/10/20
PB - Taylor & Francis
SP - 458-464
IS - 8
VL - 16
PMID - 19839790
SN - 1071-7544
SN - 1521-0464
ER -
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BibTex (до 50 авторов)
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@article{2009_Lin,
author = {Chuen-Chang Lin and Cheng-Wei Lin},
title = {Preparation ofN,O-carboxymethyl chitosan nanoparticles as an insulin carrier},
journal = {Drug Delivery},
year = {2009},
volume = {16},
publisher = {Taylor & Francis},
month = {oct},
url = {https://doi.org/10.3109/10717540903353090},
number = {8},
pages = {458--464},
doi = {10.3109/10717540903353090}
}
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MLA
Скопировать
Lin, Chuen-Chang, and Cheng-Wei Lin. “Preparation ofN,O-carboxymethyl chitosan nanoparticles as an insulin carrier.” Drug Delivery, vol. 16, no. 8, Oct. 2009, pp. 458-464. https://doi.org/10.3109/10717540903353090.
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