Open Access
Drug Delivery, volume 16, issue 8, pages 458-464
Preparation ofN,O-carboxymethyl chitosan nanoparticles as an insulin carrier
Publication type: Journal Article
Publication date: 2009-10-20
General Medicine
Pharmaceutical Science
Abstract
The aim of this research was to develop pH-sensitive insulin-loaded NOCC (N,O-carboxymethyl chitosan) nanoparticles for the controlled release of insulin via the oral route. Thus, in this study, insulin-loaded NOCC nanoparticles were prepared by ionic gelation of NOCC with TPP (tripolyphosphate). NOCC nanoparticles were formed at conditions of 2 mg/ml of NOCC and 1 mg/ml of TPP. It was found that the encapsulation efficiency and process yield decreased with increasing NOCC to TPP weight ratio. Furthermore, the cumulative release of insulin from insulin-loaded NOCC nanoparticles decreased with decreasing NOCC-to-TPP weight ratio, but it increased with decreasing the initial concentration of insulin. The higher the pH of the phosphate buffered saline, the greater the amount of cumulative release of insulin-loaded NOCC nanoparticles, and thus they could protect insulin from acid.
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Lin C., Lin C. Preparation ofN,O-carboxymethyl chitosan nanoparticles as an insulin carrier // Drug Delivery. 2009. Vol. 16. No. 8. pp. 458-464.
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Lin C., Lin C. Preparation ofN,O-carboxymethyl chitosan nanoparticles as an insulin carrier // Drug Delivery. 2009. Vol. 16. No. 8. pp. 458-464.
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RIS
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TY - JOUR
DO - 10.3109/10717540903353090
UR - https://doi.org/10.3109/10717540903353090
TI - Preparation ofN,O-carboxymethyl chitosan nanoparticles as an insulin carrier
T2 - Drug Delivery
AU - Lin, Chuen-Chang
AU - Lin, Cheng-Wei
PY - 2009
DA - 2009/10/20
PB - Taylor & Francis
SP - 458-464
IS - 8
VL - 16
SN - 1071-7544
SN - 1521-0464
ER -
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BibTex (up to 50 authors)
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@article{2009_Lin,
author = {Chuen-Chang Lin and Cheng-Wei Lin},
title = {Preparation ofN,O-carboxymethyl chitosan nanoparticles as an insulin carrier},
journal = {Drug Delivery},
year = {2009},
volume = {16},
publisher = {Taylor & Francis},
month = {oct},
url = {https://doi.org/10.3109/10717540903353090},
number = {8},
pages = {458--464},
doi = {10.3109/10717540903353090}
}
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MLA
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Lin, Chuen-Chang, and Cheng-Wei Lin. “Preparation ofN,O-carboxymethyl chitosan nanoparticles as an insulin carrier.” Drug Delivery, vol. 16, no. 8, Oct. 2009, pp. 458-464. https://doi.org/10.3109/10717540903353090.