Electrospinning vs. Electro-Assisted Solution Blow Spinning for Fabrication of Fibrous Scaffolds for Tissue Engineering

Tatiana Demina ¹

E. N. Bolbasov ²

Maria Peshkova ^{1, 3, 4}

Yuri M. Efremov ³

Polina Y. Bikmulina ¹

Aisylu V Birdibekova ⁵

Tatiana Popyrina ⁵

Nastasia V. Kosheleva ^{3, 4, 6}

S. I. Tverdokhlebov ²

Peter S. Timashev ^{1, 3, 7}

Tatiana Akopova ⁵

Show full list: 11 authors

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World-Class Research Center “Digital Biodesign and Personalized Healthcare”, Sechenov First Moscow State Medical University, 8-2 Trubetskaya St., 119991 Moscow, Russia |

Weinberg Research Center, School of Nuclear Science & Engineering, National Research Tomsk Polytechnic University, 30 Lenin Ave, 634050 Tomsk, Russia |

Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, 8-2 Trubetskaya st., 119991 Moscow, Russia |

⁴

Laboratory of Clinical Smart Nanotechnologies, Sechenov First Moscow State Medical University, 8-2 Trubetskaya St., 119991 Moscow, Russia |

⁵

Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences, 70 Profsoyuznaya St., 117393 Moscow, Russia |

⁶

FSBSI Institute of General Pathology and Pathophysiology, 8 Baltiyskaya Ulitsa, 125315 Moscow, Russia |

⁷

Chemistry Department, Lomonosov Moscow State University, Leninskiye Gory 1-3, 119991 Moscow, Russia |

Publication type: Journal Article

Publication date: 2022-12-01

MDPI

Journal: Polymers

scimago Q1

SJR: 0.800

CiteScore: 8.0

Impact factor: 4.7

ISSN: 20734360

DOI: 10.3390/polym14235254

Copy DOI

PubMed ID: 36501648

General Chemistry

Polymers and Plastics

Abstract

Biodegradable polymeric fibrous non-woven materials are widely used type of scaffolds for tissue engineering. Their morphology and properties could be controlled by composition and fabrication technology. This work is aimed at development of fibrous scaffolds from a multicomponent polymeric system containing biodegradable synthetic (polylactide, polycaprolactone) and natural (gelatin, chitosan) components using different methods of non-woven mats fabrication: electrospinning and electro-assisted solution blow spinning. The effect of the fabrication technique of the fibrous materials onto their morphology and properties, including the ability to support adhesion and growth of cells, was evaluated. The mats fabricated using electrospinning technology consist of randomly oriented monofilament fibers, while application of solution blow spinning gave a rise to chaotically arranged multifilament fibers. Cytocompatibility of all fabricated fibrous mats was confirmed using in vitro analysis of metabolic activity, proliferative capacity and morphology of NIH 3T3 cell line. Live/Dead assay revealed the formation of the highest number of cell–cell contacts in the case of multifilament sample formed by electro-assisted solution blow spinning technology.

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