Open Access
Open access
volume 10 issue 10 pages 1735

The Role of Reactive Species on Innate Immunity

Publication typeJournal Article
Publication date2022-10-17
scimago Q1
wos Q2
SJR1.024
CiteScore9.9
Impact factor3.4
ISSN2076393X
Drug Discovery
Pharmacology
Infectious Diseases
Pharmacology (medical)
Immunology
Abstract

This review examines the role of reactive species RS (of oxygen ROS, nitrogen RNS and halogen RHS) on innate immunity. The importance of these species in innate immunity was first recognized in phagocytes that underwent a “respiratory burst” after activation. The anion superoxide •O2− and hydrogen peroxide H2O2 are detrimental to the microbial population. NADPH oxidase NOx, as an •O2− producer is essential for microbial destruction, and patients lacking this functional oxidase are more susceptible to microbial infections. Reactive nitrogen species RNS (the most important are nitric oxide radical -•NO, peroxynitrite ONOO— and its derivatives), are also harmful to microorganisms, including bacteria, viruses, and parasites. Hypochlorous acid HOCl and hypothiocyanous acid HOSCN synthesized through the enzyme myeloperoxidase MPO, which catalyzes the reaction between H2O2 and Cl− or SCN−, are important inorganic bactericidal molecules, effective against a wide range of microbes. This review also discusses the role of antimicrobial peptides AMPs and their induction of ROS. In summary, reactive species RS are the heart of the innate immune system, and they are necessary for microbial lysis in infections that can affect mammals throughout their lives.

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GOST |
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GOST Copy
Andrés C. et al. The Role of Reactive Species on Innate Immunity // Vaccines. 2022. Vol. 10. No. 10. p. 1735.
GOST all authors (up to 50) Copy
Andrés C., Pérez de la Lastra J. M., Juan C., Plou F., Pérez Lebeña E. The Role of Reactive Species on Innate Immunity // Vaccines. 2022. Vol. 10. No. 10. p. 1735.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.3390/vaccines10101735
UR - https://doi.org/10.3390/vaccines10101735
TI - The Role of Reactive Species on Innate Immunity
T2 - Vaccines
AU - Andrés, Celia
AU - Pérez de la Lastra, José M.
AU - Juan, Celia
AU - Plou, Francisco
AU - Pérez Lebeña, Eduardo
PY - 2022
DA - 2022/10/17
PB - MDPI
SP - 1735
IS - 10
VL - 10
PMID - 36298601
SN - 2076-393X
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2022_Andrés,
author = {Celia Andrés and José M. Pérez de la Lastra and Celia Juan and Francisco Plou and Eduardo Pérez Lebeña},
title = {The Role of Reactive Species on Innate Immunity},
journal = {Vaccines},
year = {2022},
volume = {10},
publisher = {MDPI},
month = {oct},
url = {https://doi.org/10.3390/vaccines10101735},
number = {10},
pages = {1735},
doi = {10.3390/vaccines10101735}
}
MLA
Cite this
MLA Copy
Andrés, Celia, et al. “The Role of Reactive Species on Innate Immunity.” Vaccines, vol. 10, no. 10, Oct. 2022, p. 1735. https://doi.org/10.3390/vaccines10101735.