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Synthesis of N-Heterocyclic Analogues of 28-O-Methyl Betulinate, and Their Antibacterial and Antifungal Properties
Тип публикации: Journal Article
Дата публикации: 2019-12-19
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Краткое описание
The paper presents the results on the one-pot pyridine quaternization using betulinic 28-O-methyl ester (1) and Tempo+Br3− cation followed by reduction of the resulting salt (2) to 1,2,5,6-tetrahydropyridine derivative (3). The structures of new compounds are confirmed by means of 1D and 2D-NMR spectroscopy, as well as MALDI TOF/TOF spectrometry. The derivatives 2 and 3 are active against S. aureus at the minimum inhibitory concentration (MIC) of 4 μg/mL and 16 μg/mL, correspondingly.
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Shakurova E. R., Parfenova L. V. Synthesis of N-Heterocyclic Analogues of 28-O-Methyl Betulinate, and Their Antibacterial and Antifungal Properties // MolBank. 2019. Vol. 2020. No. 1. p. M1100.
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Shakurova E. R., Parfenova L. V. Synthesis of N-Heterocyclic Analogues of 28-O-Methyl Betulinate, and Their Antibacterial and Antifungal Properties // MolBank. 2019. Vol. 2020. No. 1. p. M1100.
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TY - JOUR
DO - 10.3390/M1100
UR - https://doi.org/10.3390/M1100
TI - Synthesis of N-Heterocyclic Analogues of 28-O-Methyl Betulinate, and Their Antibacterial and Antifungal Properties
T2 - MolBank
AU - Shakurova, Elvira R
AU - Parfenova, Lyudmila V.
PY - 2019
DA - 2019/12/19
PB - MDPI
SP - M1100
IS - 1
VL - 2020
SN - 1422-8599
ER -
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@article{2019_Shakurova,
author = {Elvira R Shakurova and Lyudmila V. Parfenova},
title = {Synthesis of N-Heterocyclic Analogues of 28-O-Methyl Betulinate, and Their Antibacterial and Antifungal Properties},
journal = {MolBank},
year = {2019},
volume = {2020},
publisher = {MDPI},
month = {dec},
url = {https://doi.org/10.3390/M1100},
number = {1},
pages = {M1100},
doi = {10.3390/M1100}
}
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MLA
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Shakurova, Elvira R., and Lyudmila V. Parfenova. “Synthesis of N-Heterocyclic Analogues of 28-O-Methyl Betulinate, and Their Antibacterial and Antifungal Properties.” MolBank, vol. 2020, no. 1, Dec. 2019, p. M1100. https://doi.org/10.3390/M1100.
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