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Antibiotics, том 8, издание 4, номер публикации: 236

Exploitation of potentially new antibiotics from mangrove actinobacteria in maowei sea by combination of multiple discovery strategies

Lu Qin-Pei 1, 2
Ye Jing-Jing 3
Huang Yong-Mei 4
Liu Di 5
Liu Li-Fang 1, 2
Dong Kun 6
Osterman Ilya A. 7, 8
Sergiev Petr V. 7, 8
Dontsova Olga A. 7, 8, 9
Jia Shu-Han 3
Huang Da-lin 3
1
 
Department of Microbial Chemistry, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
2
 
Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
3
 
College of Basic Medical Sciences, Guilin Medical University, Guilin 541004, China
4
 
Zhanjiang for R&D Marine Microbial Resources in the Beibu Gulf Rim, Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, China
5
 
College of Life Sciences, Jiamusi University, Jiamusi 154007, China
6
 
College of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China
Тип документаJournal Article
Дата публикации2019-11-27
ИздательMultidisciplinary Digital Publishing Institute (MDPI)
Название журналаAntibiotics
Квартиль по SCImagoQ1
Квартиль по Web of ScienceQ1
Импакт-фактор 20215.22
ISSN20796382
Biochemistry
Microbiology (medical)
Microbiology
Infectious Diseases
Pharmacology (medical)
General Pharmacology, Toxicology and Pharmaceutics
Краткое описание

Rediscovery of known antibiotics from actinobacteria, especially Streptomyces, has become a bottleneck issue. Nowadays, more specific identification and dereplication could be acquired by a combination of modern analytic techniques with various databases. In this study, 261 actinobacterial strains were isolated from 8 mangrove soil samples by culture-dependent method. A total of 83 strains were selected to evaluate antibacterial activities and mechanisms by disc diffusion method and a unique double fluorescent protein reporter system (pDualrep2), respectively. Thirty-two strains exhibited antagonistic activity against at least one of the “ESKAPE” pathogens. Four Streptomyces strains (B475, B486, B353, and B98) showed strong inhibitory activity against Gram-positive bacteria and induced DNA damage SOS response. One Micromonospora strain (B704) exhibited inhibitory activity against several pathogens and induced attenuation-based translational inhibitors reporter. Seven members of quinoxaline-type antibiotics including quinomycin A, quinomycin monosulfoxide, and other five putative new analogues were found from the culture broth of strain B475 by a combination of anti-MRSA guide, HPTLC, HPLC-UV, and UPLC-UV-HRESIMS/MS analysis, Chemspider searching, and MS/MS-based molecular networking analysis. In conclusion, this study not only demonstrated that mangrove is a rich source of actinobacteria with the potentially new antibiotics but showed rapid dereplication of known antibiotics in the early stage can improve efficiency for the discovery of new antibiotics.

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ГОСТ |
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1. Lu Q.-P. и др. Exploitation of Potentially New Antibiotics from Mangrove Actinobacteria in Maowei Sea by Combination of Multiple Discovery Strategies // Antibiotics. 2019. Т. 8. № 4. С. 236.
RIS |
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TY - JOUR

DO - 10.3390/antibiotics8040236

UR - http://dx.doi.org/10.3390/antibiotics8040236

TI - Exploitation of Potentially New Antibiotics from Mangrove Actinobacteria in Maowei Sea by Combination of Multiple Discovery Strategies

T2 - Antibiotics

AU - Lu, Qin-Pei

AU - Ye, Jing-Jing

AU - Huang, Yong-Mei

AU - Liu, Di

AU - Liu, Li-Fang

AU - Dong, Kun

AU - Razumova, Elizaveta A.

AU - Osterman, Ilya A.

AU - Sergiev, Petr V.

AU - Dontsova, Olga A.

AU - Jia, Shu-Han

AU - Huang, Da-Lin

AU - Sun, Cheng-Hang

PY - 2019

DA - 2019/11/27

PB - MDPI AG

SP - 236

IS - 4

VL - 8

SN - 2079-6382

ER -

BibTex |
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@article{2019,

doi = {10.3390/antibiotics8040236},

url = {https://doi.org/10.3390%2Fantibiotics8040236},

year = 2019,

month = {nov},

publisher = {{MDPI} {AG}},

volume = {8},

number = {4},

pages = {236},

author = {Qin-Pei Lu and Jing-Jing Ye and Yong-Mei Huang and Di Liu and Li-Fang Liu and Kun Dong and Elizaveta A. Razumova and Ilya A. Osterman and Petr V. Sergiev and Olga A. Dontsova and Shu-Han Jia and Da-Lin Huang and Cheng-Hang Sun},

title = {Exploitation of Potentially New Antibiotics from Mangrove Actinobacteria in Maowei Sea by Combination of Multiple Discovery Strategies}

}

MLA
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Lu, Qin-Pei et al. “Exploitation of Potentially New Antibiotics from Mangrove Actinobacteria in Maowei Sea by Combination of Multiple Discovery Strategies.” Antibiotics 8.4 (2019): 236. Crossref. Web.