Open Access
Gels, volume 8, issue 12, pages 765
Preparation of Protein Aerogel Particles for the Development of Innovative Drug Delivery Systems
Lovskaya Daria
1
,
Bezchasnyuk Anna
1
,
Mochalova Maria
1
,
Tsygankov Pavel
1
,
Zorkina Y.
2
,
Zubkov Eugene
2
,
Ochneva Aleksandra
2
,
Gurina Olga
2
,
Silantyev Artemiy
2
,
Majouga Alexander
1
,
Publication type: Journal Article
Publication date: 2022-11-24
Organic Chemistry
Polymers and Plastics
Bioengineering
Biomaterials
Abstract
The research was oriented towards the preparation of aerogel particles based on egg white and whey protein isolate using various dispersion methods: dripping, spraying, and homogenization. Based on the results of analytical studies, the most appropriate samples were selected to obtain aerogels loaded with the drug. The results of the experimental research were used to study methods for obtaining nasal drug delivery systems based on aerogels. Protein aerogels were obtained by thermal gelation followed by supercritical drying. The obtained particles of protein aerogels have a specific surface area of up to 350 m2/g with a pore volume of up to 2.9 cm3/g, as well as a porosity of up to 95%. The results of experimental studies have shown that changing the dispersion method makes it possible to control the structural characteristics of protein aerogel particles. The results of the studies were applied to obtain innovative nasal drug delivery systems for the treatment of socially significant diseases. Analytical studies were conducted to determine the amount and state of adsorbed drugs in protein aerogel particles, as well as in vivo experiments on the distribution of clomipramine in blood plasma and brain tissue of rats to study the pharmacokinetics and bioavailability of the resulting drug-loaded protein aerogel.
Citations by journals
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1
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Gels
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Gels
1 publication, 25%
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Molecules
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Molecules
1 publication, 25%
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Russian Journal of General Chemistry
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Russian Journal of General Chemistry
1 publication, 25%
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Macromolecular Rapid Communications
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Macromolecular Rapid Communications
1 publication, 25%
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1
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Citations by publishers
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1
2
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 50%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 25%
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Wiley
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Wiley
1 publication, 25%
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1
2
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Lovskaya D. et al. Preparation of Protein Aerogel Particles for the Development of Innovative Drug Delivery Systems // Gels. 2022. Vol. 8. No. 12. p. 765.
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Lovskaya D., Bezchasnyuk A., Mochalova M., Tsygankov P., Lebedev V. E., Zorkina Y., Zubkov E., Ochneva A., Gurina O., Silantyev A., Majouga A., Menshutina N. Preparation of Protein Aerogel Particles for the Development of Innovative Drug Delivery Systems // Gels. 2022. Vol. 8. No. 12. p. 765.
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TY - JOUR
DO - 10.3390/gels8120765
UR - https://doi.org/10.3390%2Fgels8120765
TI - Preparation of Protein Aerogel Particles for the Development of Innovative Drug Delivery Systems
T2 - Gels
AU - Lovskaya, Daria
AU - Bezchasnyuk, Anna
AU - Mochalova, Maria
AU - Tsygankov, Pavel
AU - Lebedev, Vladimir E
AU - Zorkina, Y.
AU - Zubkov, Eugene
AU - Ochneva, Aleksandra
AU - Gurina, Olga
AU - Silantyev, Artemiy
AU - Majouga, Alexander
AU - Menshutina, Natalia
PY - 2022
DA - 2022/11/24 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 765
IS - 12
VL - 8
SN - 2310-2861
ER -
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@article{2022_Lovskaya,
author = {Daria Lovskaya and Anna Bezchasnyuk and Maria Mochalova and Pavel Tsygankov and Vladimir E Lebedev and Y. Zorkina and Eugene Zubkov and Aleksandra Ochneva and Olga Gurina and Artemiy Silantyev and Alexander Majouga and Natalia Menshutina},
title = {Preparation of Protein Aerogel Particles for the Development of Innovative Drug Delivery Systems},
journal = {Gels},
year = {2022},
volume = {8},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {nov},
url = {https://doi.org/10.3390%2Fgels8120765},
number = {12},
pages = {765},
doi = {10.3390/gels8120765}
}
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MLA
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Lovskaya, Daria, et al. “Preparation of Protein Aerogel Particles for the Development of Innovative Drug Delivery Systems.” Gels, vol. 8, no. 12, Nov. 2022, p. 765. https://doi.org/10.3390%2Fgels8120765.