Open Access

International Journal of Molecular Sciences

, том 20 , издание 23 , страницы 6041

Dead Cas Systems: Types, Principles, and Applications

Тип публикации: Journal Article

Дата публикации: 2019-11-30

MDPI

International Journal of Molecular Sciences

SCImago Q1

Tоп 10% SCImago

WOS Q1

БС1

SJR: 1.316

CiteScore: 10

Impact factor: 5.6

ISSN: 16616596, 14220067

DOI: 10.3390/ijms20236041

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PubMed ID: 31801211

Catalysis

Organic Chemistry

Inorganic Chemistry

Physical and Theoretical Chemistry

Computer Science Applications

Spectroscopy

Molecular Biology

General Medicine

Краткое описание

The gene editing tool CRISPR-Cas has become the foundation for developing numerous molecular systems used in research and, increasingly, in medical practice. In particular, Cas proteins devoid of nucleolytic activity (dead Cas proteins; dCas) can be used to deliver functional cargo to programmed sites in the genome. In this review, we describe current CRISPR systems used for developing different dCas-based molecular approaches and summarize their most significant applications. We conclude with comments on the state-of-art in the CRISPR field and future directions.

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ГОСТ |

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Brezgin S. et al. Dead Cas Systems: Types, Principles, and Applications // International Journal of Molecular Sciences. 2019. Vol. 20. No. 23. p. 6041.

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Brezgin S., Kostyusheva A., Kostyushev D., Chulanov V. Dead Cas Systems: Types, Principles, and Applications // International Journal of Molecular Sciences. 2019. Vol. 20. No. 23. p. 6041.

RIS |

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TY - JOUR

DO - 10.3390/ijms20236041

UR - https://doi.org/10.3390/ijms20236041

TI - Dead Cas Systems: Types, Principles, and Applications

T2 - International Journal of Molecular Sciences

AU - Brezgin, Sergey

AU - Kostyusheva, Anastasiya

AU - Kostyushev, Dmitry

AU - Chulanov, Vladimir

PY - 2019

DA - 2019/11/30

PB - MDPI

SP - 6041

IS - 23

VL - 20

PMID - 31801211

SN - 1661-6596

SN - 1422-0067

ER -

BibTex |

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@article{2019_Brezgin,

author = {Sergey Brezgin and Anastasiya Kostyusheva and Dmitry Kostyushev and Vladimir Chulanov},

title = {Dead Cas Systems: Types, Principles, and Applications},

journal = {International Journal of Molecular Sciences},

year = {2019},

volume = {20},

publisher = {MDPI},

month = {nov},

url = {https://doi.org/10.3390/ijms20236041},

number = {23},

pages = {6041},

doi = {10.3390/ijms20236041}

}

MLA

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MLA Скопировать

Brezgin, Sergey, et al. “Dead Cas Systems: Types, Principles, and Applications.” International Journal of Molecular Sciences, vol. 20, no. 23, Nov. 2019, p. 6041. https://doi.org/10.3390/ijms20236041.

Издатель

MDPI

Журнал

International Journal of Molecular Sciences

SCImago Q1

Tоп 10% SCImago

WOS Q1

БС1

SJR

1.316

CiteScore

Impact factor