Open Access
International Journal of Molecular Sciences, volume 20, issue 23, pages 6041
Dead Cas Systems: Types, Principles, and Applications
1
National Medical Research Center of Tuberculosis and Infectious Diseases, Ministry of Health, Moscow 127994, Russia
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Publication type: Journal Article
Publication date: 2019-11-30
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 16616596, 14220067
PubMed ID:
31801211
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
The gene editing tool CRISPR-Cas has become the foundation for developing numerous molecular systems used in research and, increasingly, in medical practice. In particular, Cas proteins devoid of nucleolytic activity (dead Cas proteins; dCas) can be used to deliver functional cargo to programmed sites in the genome. In this review, we describe current CRISPR systems used for developing different dCas-based molecular approaches and summarize their most significant applications. We conclude with comments on the state-of-art in the CRISPR field and future directions.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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GOST
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Brezgin S. et al. Dead Cas Systems: Types, Principles, and Applications // International Journal of Molecular Sciences. 2019. Vol. 20. No. 23. p. 6041.
GOST all authors (up to 50)
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Brezgin S., Kostyusheva A., Kostyushev D., Chulanov V. Dead Cas Systems: Types, Principles, and Applications // International Journal of Molecular Sciences. 2019. Vol. 20. No. 23. p. 6041.
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TY - JOUR
DO - 10.3390/ijms20236041
UR - https://doi.org/10.3390%2Fijms20236041
TI - Dead Cas Systems: Types, Principles, and Applications
T2 - International Journal of Molecular Sciences
AU - Brezgin, Sergey
AU - Kostyusheva, Anastasiya
AU - Kostyushev, Dmitry
AU - Chulanov, Vladimir
PY - 2019
DA - 2019/11/30 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 6041
IS - 23
VL - 20
PMID - 31801211
SN - 1661-6596
SN - 1422-0067
ER -
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@article{2019_Brezgin,
author = {Sergey Brezgin and Anastasiya Kostyusheva and Dmitry Kostyushev and Vladimir Chulanov},
title = {Dead Cas Systems: Types, Principles, and Applications},
journal = {International Journal of Molecular Sciences},
year = {2019},
volume = {20},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {nov},
url = {https://doi.org/10.3390%2Fijms20236041},
number = {23},
pages = {6041},
doi = {10.3390/ijms20236041}
}
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MLA
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Brezgin, Sergey, et al. “Dead Cas Systems: Types, Principles, and Applications.” International Journal of Molecular Sciences, vol. 20, no. 23, Nov. 2019, p. 6041. https://doi.org/10.3390%2Fijms20236041.