Open Access
Enzymes, Reacting with Organophosphorus Compounds as Detoxifiers: Diversity and Functions
Ilya Lyagin
1
,
Publication type: Journal Article
Publication date: 2021-02-10
scimago Q1
wos Q1
SJR: 1.273
CiteScore: 9.0
Impact factor: 4.9
ISSN: 16616596, 14220067
PubMed ID:
33578824
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
Organophosphorus compounds (OPCs) are able to interact with various biological targets in living organisms, including enzymes. The binding of OPCs to enzymes does not always lead to negative consequences for the body itself, since there are a lot of natural biocatalysts that can catalyze the chemical transformations of the OPCs via hydrolysis or oxidation/reduction and thereby provide their detoxification. Some of these enzymes, their structural differences and identity, mechanisms, and specificity of catalytic action are discussed in this work, including results of computational modeling. Phylogenetic analysis of these diverse enzymes was specially realized for this review to emphasize a great area for future development(s) and applications.
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Metrics
30
Total citations:
30
Citations from 2024:
10
(34.48%)
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MLA
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GOST
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Lyagin I., Efremenko E. N. Enzymes, Reacting with Organophosphorus Compounds as Detoxifiers: Diversity and Functions // International Journal of Molecular Sciences. 2021. Vol. 22. No. 4. p. 1761.
GOST all authors (up to 50)
Copy
Lyagin I., Efremenko E. N. Enzymes, Reacting with Organophosphorus Compounds as Detoxifiers: Diversity and Functions // International Journal of Molecular Sciences. 2021. Vol. 22. No. 4. p. 1761.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/ijms22041761
UR - https://doi.org/10.3390/ijms22041761
TI - Enzymes, Reacting with Organophosphorus Compounds as Detoxifiers: Diversity and Functions
T2 - International Journal of Molecular Sciences
AU - Lyagin, Ilya
AU - Efremenko, E. N.
PY - 2021
DA - 2021/02/10
PB - MDPI
SP - 1761
IS - 4
VL - 22
PMID - 33578824
SN - 1661-6596
SN - 1422-0067
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2021_Lyagin,
author = {Ilya Lyagin and E. N. Efremenko},
title = {Enzymes, Reacting with Organophosphorus Compounds as Detoxifiers: Diversity and Functions},
journal = {International Journal of Molecular Sciences},
year = {2021},
volume = {22},
publisher = {MDPI},
month = {feb},
url = {https://doi.org/10.3390/ijms22041761},
number = {4},
pages = {1761},
doi = {10.3390/ijms22041761}
}
Cite this
MLA
Copy
Lyagin, Ilya, and E. N. Efremenko. “Enzymes, Reacting with Organophosphorus Compounds as Detoxifiers: Diversity and Functions.” International Journal of Molecular Sciences, vol. 22, no. 4, Feb. 2021, p. 1761. https://doi.org/10.3390/ijms22041761.