Open Access
Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe3O4 Nanoparticles with a SiO2/PEG Shell and Study of Their Effects on Cancer Cell Lines
Alexandra G Pershina
2, 3
,
Marina S Valova
1
,
Lina V Efimova
2
,
Alexandra A Syomchina
4
,
M.A. Uimin
5
,
A.S. Minin
5
,
Galina L. Levit
1
,
Valery Charushin
1, 6
2
Publication type: Journal Article
Publication date: 2022-08-13
scimago Q1
wos Q1
SJR: 1.273
CiteScore: 9.0
Impact factor: 4.9
ISSN: 16616596, 14220067
PubMed ID:
36012356
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
Novel nanocomposite materials based on Fe3O4 magnetic nanoparticles (MNPs) coated with silica and covalently modified by [(3-triethoxysilyl)propyl]succinic acid–polyethylene glycol (PEG 3000) conjugate, which provides a high level of doxorubicin (Dox) loading, were obtained. The efficiency of Dox desorption from the surface of nanomaterials under the action of an alternating magnetic field (AMF) in acidic and neutral media was evaluated. Their high cytotoxicity against tumor cells, as well as the drug release upon application of AMF, which leads to an increase in the cytotoxic effect, was demonstrated.
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Total citations:
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Citations from 2024:
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(40%)
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MLA
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GOST
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Demin A. V. et al. Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe3O4 Nanoparticles with a SiO2/PEG Shell and Study of Their Effects on Cancer Cell Lines // International Journal of Molecular Sciences. 2022. Vol. 23. No. 16. p. 9093.
GOST all authors (up to 50)
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Demin A. V., Vakhrushev A. V., Pershina A. G., Valova M. S., Efimova L. V., Syomchina A. A., Uimin M., Minin A., Levit G. L., Krasnov V. P., Charushin V. Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe3O4 Nanoparticles with a SiO2/PEG Shell and Study of Their Effects on Cancer Cell Lines // International Journal of Molecular Sciences. 2022. Vol. 23. No. 16. p. 9093.
Cite this
RIS
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TY - JOUR
DO - 10.3390/ijms23169093
UR - https://www.mdpi.com/1422-0067/23/16/9093
TI - Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe3O4 Nanoparticles with a SiO2/PEG Shell and Study of Their Effects on Cancer Cell Lines
T2 - International Journal of Molecular Sciences
AU - Demin, Alexander V.
AU - Vakhrushev, Alexander V
AU - Pershina, Alexandra G
AU - Valova, Marina S
AU - Efimova, Lina V
AU - Syomchina, Alexandra A
AU - Uimin, M.A.
AU - Minin, A.S.
AU - Levit, Galina L.
AU - Krasnov, Victor P.
AU - Charushin, Valery
PY - 2022
DA - 2022/08/13
PB - MDPI
SP - 9093
IS - 16
VL - 23
PMID - 36012356
SN - 1661-6596
SN - 1422-0067
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2022_Demin,
author = {Alexander V. Demin and Alexander V Vakhrushev and Alexandra G Pershina and Marina S Valova and Lina V Efimova and Alexandra A Syomchina and M.A. Uimin and A.S. Minin and Galina L. Levit and Victor P. Krasnov and Valery Charushin},
title = {Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe3O4 Nanoparticles with a SiO2/PEG Shell and Study of Their Effects on Cancer Cell Lines},
journal = {International Journal of Molecular Sciences},
year = {2022},
volume = {23},
publisher = {MDPI},
month = {aug},
url = {https://www.mdpi.com/1422-0067/23/16/9093},
number = {16},
pages = {9093},
doi = {10.3390/ijms23169093}
}
Cite this
MLA
Copy
Demin, Alexander V., et al. “Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe3O4 Nanoparticles with a SiO2/PEG Shell and Study of Their Effects on Cancer Cell Lines.” International Journal of Molecular Sciences, vol. 23, no. 16, Aug. 2022, p. 9093. https://www.mdpi.com/1422-0067/23/16/9093.