Open Access

International Journal of Molecular Sciences, volume 24, issue 10, pages 9100

Friunavirus Phage-Encoded Depolymerases Specific to Different Capsular Types of Acinetobacter baumannii

Timoshina Olga Yu ^{1, 2}

Kasimova Anastasia A ³

Shneider M. ²

Matyuta Ilya O. ^{4, 5}

Nikolaeva Alena Y. ⁶

Evseev Peter ²

Arbatsky Nikolay P. ³

Shashkov Alexander S. ³

Chizhov Alexander O ³

Шеленков А. А. ⁷

Mikhaylova Yulia V. ⁷

Slukin Pavel V ¹

Volozhantsev Nikolay V ¹

Boyko Konstantin M. ⁴

Knirel Yuriy A. ³

Miroshnikov K. A. ²

Popova Anastasiya V. ¹

Hide authors affiliations Show authors affiliations: 7 affiliations

State Research Center for Applied Microbiology and Biotechnology, 142279 Obolensk, Russia |

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia |

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russia |

⁴

Bach Institute of Biochemistry, Research Centre of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia

Bach Institute of Biochemistry of the Russian Academy of Sciences

Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences

⁵

Center for Photonics and 2D Materials, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Russia |

⁶

Complex of NBICS Technologies, National Research Center “Kurchatov Institute”, 123182 Moscow, Russia |

⁷

Central Scientific Research Institute of Epidemiology, 111123 Moscow, Russia |

Publication type: Journal Article

Publication date: 2023-05-22

Multidisciplinary Digital Publishing Institute (MDPI)

Journal: International Journal of Molecular Sciences

Quartile SCImago

Quartile WOS

Impact factor: 5.6

ISSN: 16616596, 14220067

DOI: 10.3390/ijms24109100

Copy DOI

PubMed ID: 37240444

Catalysis

Organic Chemistry

Inorganic Chemistry

Physical and Theoretical Chemistry

Computer Science Applications

Spectroscopy

Molecular Biology

General Medicine

Abstract

Acinetobacter baumannii is a critical priority nosocomial pathogen that produces a variety of capsular polysaccharides (CPSs), the primary receptors for specific depolymerase-carrying phages. In this study, the tailspike depolymerases (TSDs) encoded in genomes of six novel Friunaviruses, APK09, APK14, APK16, APK86, APK127v, APK128, and one previously described Friunavirus phage, APK37.1, were characterized. For all TSDs, the mechanism of specific cleavage of corresponding A. baumannii capsular polysaccharides (CPSs) was established. The structures of oligosaccharide fragments derived from K9, K14, K16, K37/K3-v1, K86, K127, and K128 CPSs degradation by the recombinant depolymerases have been determined. The crystal structures of three of the studied TSDs were obtained. A significant reduction in mortality of Galleria mellonella larvae infected with A. baumannii of K9 capsular type was shown in the example of recombinant TSD APK09_gp48. The data obtained will provide a better understanding of the interaction of phage–bacterial host systems and will contribute to the formation of principles of rational usage of lytic phages and phage-derived enzymes as antibacterial agents.

By date By citations

Citations by journals

	1
Virus Research	Virus Research, 1, 20% Virus Research 1 publication, 20%
Microbiology spectrum	Microbiology spectrum, 1, 20% Microbiology spectrum 1 publication, 20%
International Journal of Biological Macromolecules	International Journal of Biological Macromolecules, 1, 20% International Journal of Biological Macromolecules 1 publication, 20%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 20% International Journal of Molecular Sciences 1 publication, 20%
	1

Citations by publishers

	1 2
Elsevier	Elsevier, 2, 40% Elsevier 2 publications, 40%
American Society for Microbiology	American Society for Microbiology, 1, 20% American Society for Microbiology 1 publication, 20%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 1, 20% Multidisciplinary Digital Publishing Institute (MDPI) 1 publication, 20%
	1 2

We do not take into account publications that without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2023,2024],"ids":[0,0],"codes":[0,0],"imageUrls":["",""],"datasets":[{"label":"Citations number","data":[3,2],"backgroundColor":["#3B82F6","#3B82F6"],"percentage":["60","40"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Virus Research","Microbiology spectrum","International Journal of Biological Macromolecules","International Journal of Molecular Sciences"],"ids":[24704,17855,23035,14627],"codes":[0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/VPE7q24PXoHr5SS2SqfEgxccSMUxWLfZINOX60uo_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp"],"datasets":[{"label":"","data":[1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[20,20,20,20],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Elsevier","American Society for Microbiology","Multidisciplinary Digital Publishing Institute (MDPI)"],"ids":[17,142,202],"codes":[0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/VPE7q24PXoHr5SS2SqfEgxccSMUxWLfZINOX60uo_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp"],"datasets":[{"label":"","data":[2,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6"],"percentage":[40,20,20],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}

Publication PDF

Metrics

Cite this

GOST |

Cite this

GOST Copy

Timoshina O. Yu. et al. Friunavirus Phage-Encoded Depolymerases Specific to Different Capsular Types of Acinetobacter baumannii // International Journal of Molecular Sciences. 2023. Vol. 24. No. 10. p. 9100.

GOST all authors (up to 50) Copy

Timoshina O. Yu., Kasimova A. A., Shneider M., Matyuta I. O., Nikolaeva A. Y., Evseev P., Arbatsky N. P., Shashkov A. S., Chizhov A. O., Шеленков А. А., Mikhaylova Y. V., Slukin P. V., Volozhantsev N. V., Boyko K. M., Knirel Y. A., Miroshnikov K. A., Popova A. V. Friunavirus Phage-Encoded Depolymerases Specific to Different Capsular Types of Acinetobacter baumannii // International Journal of Molecular Sciences. 2023. Vol. 24. No. 10. p. 9100.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.3390/ijms24109100

UR - https://doi.org/10.3390%2Fijms24109100

TI - Friunavirus Phage-Encoded Depolymerases Specific to Different Capsular Types of Acinetobacter baumannii

T2 - International Journal of Molecular Sciences

AU - Timoshina, Olga Yu

AU - Kasimova, Anastasia A

AU - Shneider, M.

AU - Matyuta, Ilya O.

AU - Nikolaeva, Alena Y.

AU - Evseev, Peter

AU - Arbatsky, Nikolay P.

AU - Shashkov, Alexander S.

AU - Chizhov, Alexander O

AU - Шеленков, А. А.

AU - Mikhaylova, Yulia V.

AU - Slukin, Pavel V

AU - Volozhantsev, Nikolay V

AU - Boyko, Konstantin M.

AU - Knirel, Yuriy A.

AU - Miroshnikov, K. A.

AU - Popova, Anastasiya V.

PY - 2023

DA - 2023/05/22 00:00:00

PB - Multidisciplinary Digital Publishing Institute (MDPI)

SP - 9100

IS - 10

VL - 24

PMID - 37240444

SN - 1661-6596

SN - 1422-0067

ER -

BibTex |

Cite this

BibTex Copy

@article{2023_Timoshina,

author = {Olga Yu Timoshina and Anastasia A Kasimova and M. Shneider and Ilya O. Matyuta and Alena Y. Nikolaeva and Peter Evseev and Nikolay P. Arbatsky and Alexander S. Shashkov and Alexander O Chizhov and А. А. Шеленков and Yulia V. Mikhaylova and Pavel V Slukin and Nikolay V Volozhantsev and Konstantin M. Boyko and Yuriy A. Knirel and K. A. Miroshnikov and Anastasiya V. Popova},

title = {Friunavirus Phage-Encoded Depolymerases Specific to Different Capsular Types of Acinetobacter baumannii},

journal = {International Journal of Molecular Sciences},

year = {2023},

volume = {24},

publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},

month = {may},

url = {https://doi.org/10.3390%2Fijms24109100},

number = {10},

pages = {9100},

doi = {10.3390/ijms24109100}

}

MLA

Cite this

MLA Copy

Timoshina, Olga Yu., et al. “Friunavirus Phage-Encoded Depolymerases Specific to Different Capsular Types of Acinetobacter baumannii.” International Journal of Molecular Sciences, vol. 24, no. 10, May. 2023, p. 9100. https://doi.org/10.3390%2Fijms24109100.

Found error?