Open Access
Oxygenated Polyketides from Plakinastrella mamillaris as a New Chemotype of PXR Agonists
Carmen Festa
1
,
Claudio D'Amore
2
,
Barbara Renga
2
,
Gianluigi Lauro
3
,
Simona Marino
1
,
Maria Dauria
1
,
Giuseppe Bifulco
3
,
Angela Zampella
1
,
Stefano Fiorucci
2
1
2
Publication type: Journal Article
Publication date: 2013-07-02
PubMed ID:
23820629
Drug Discovery
Pharmaceutical Science
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Abstract
Further purification of the apolar extracts of the sponge Plakinastrella mamillaris, afforded a new oxygenated polyketide named gracilioether K, together with the previously isolated gracilioethers E–G and gracilioethers I and J. The structure of the new compound has been elucidated by extensive NMR (1H and 13C, COSY, HSQC, HMBC, and ROESY) and ESI-MS analysis. With the exception of gracilioether F, all compounds are endowed with potent pregnane-X-receptor (PXR) agonistic activity and therefore represent a new chemotype of potential anti-inflammatory leads. Docking calculations suggested theoretical binding modes of the identified compounds, compatible with an agonistic activity on hPXR, and clarified the molecular basis of their biological activities.
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Metrics
44
Total citations:
44
Citations from 2025:
3
(6.82%)
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MLA
Cite this
GOST
Copy
Festa C. et al. Oxygenated Polyketides from Plakinastrella mamillaris as a New Chemotype of PXR Agonists // Marine Drugs. 2013. Vol. 11. No. 7. pp. 2314-2327.
GOST all authors (up to 50)
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Festa C., D'Amore C., Renga B., Lauro G., Marino S., Dauria M., Bifulco G., Zampella A., Fiorucci S. Oxygenated Polyketides from Plakinastrella mamillaris as a New Chemotype of PXR Agonists // Marine Drugs. 2013. Vol. 11. No. 7. pp. 2314-2327.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/md11072314
UR - https://doi.org/10.3390/md11072314
TI - Oxygenated Polyketides from Plakinastrella mamillaris as a New Chemotype of PXR Agonists
T2 - Marine Drugs
AU - Festa, Carmen
AU - D'Amore, Claudio
AU - Renga, Barbara
AU - Lauro, Gianluigi
AU - Marino, Simona
AU - Dauria, Maria
AU - Bifulco, Giuseppe
AU - Zampella, Angela
AU - Fiorucci, Stefano
PY - 2013
DA - 2013/07/02
PB - MDPI
SP - 2314-2327
IS - 7
VL - 11
PMID - 23820629
SN - 1660-3397
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2013_Festa,
author = {Carmen Festa and Claudio D'Amore and Barbara Renga and Gianluigi Lauro and Simona Marino and Maria Dauria and Giuseppe Bifulco and Angela Zampella and Stefano Fiorucci},
title = {Oxygenated Polyketides from Plakinastrella mamillaris as a New Chemotype of PXR Agonists},
journal = {Marine Drugs},
year = {2013},
volume = {11},
publisher = {MDPI},
month = {jul},
url = {https://doi.org/10.3390/md11072314},
number = {7},
pages = {2314--2327},
doi = {10.3390/md11072314}
}
Cite this
MLA
Copy
Festa, Carmen, et al. “Oxygenated Polyketides from Plakinastrella mamillaris as a New Chemotype of PXR Agonists.” Marine Drugs, vol. 11, no. 7, Jul. 2013, pp. 2314-2327. https://doi.org/10.3390/md11072314.