Open Access
Total Syntheses and Preliminary Biological Evaluation of Brominated Fascaplysin and Reticulatine Alkaloids and Their Analogues
Zhidkov
1
,
Smirnova
1
,
Tryapkin
1
,
Kantemirov
1
,
Khudyakova
2
,
Malyarenko
2
,
Ermakova
2
,
Grigorchuk
3
,
Kaune
4
,
Amsberg
4, 5
,
Dyshlovoy
1, 2, 4, 5
Publication type: Journal Article
Publication date: 2019-08-25
PubMed ID:
31450717
Drug Discovery
Pharmaceutical Science
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Abstract
A simple approach toward the synthesis of the marine sponge derived pigment fascaplysin was used to obtain the marine alkaloids 3-bromofascaplysin and 3,10-dibromofascaplysin. These compounds were used for first syntheses of the alkaloids 14-bromoreticulatate and 14-bromoreticulatine. Preliminary bioassays showed that 14-bromoreticulatine has a selective antibiotic (to Pseudomonas aeruginosa) activity and reveals cytotoxicity toward human melanoma, colon, and prostate cancer cells. 3,10-Dibromofascaplysin was able to target metabolic activity of the prostate cancer cells, without disrupting cell membrane’s integrity and had a wide therapeutic window amongst the fascaplysin alkaloids.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
2
4
6
8
10
|
|
|
Marine Drugs
10 publications, 37.04%
|
|
|
European Journal of Medicinal Chemistry
2 publications, 7.41%
|
|
|
Current Medicinal Chemistry
1 publication, 3.7%
|
|
|
Biomedicines
1 publication, 3.7%
|
|
|
Frontiers in Chemistry
1 publication, 3.7%
|
|
|
ChemistrySelect
1 publication, 3.7%
|
|
|
Journal of Natural Products
1 publication, 3.7%
|
|
|
Natural Product Reports
1 publication, 3.7%
|
|
|
Studies in Natural Products Chemistry
1 publication, 3.7%
|
|
|
International Review of Neurobiology
1 publication, 3.7%
|
|
|
Scientific Reports
1 publication, 3.7%
|
|
|
Frontiers in Marine Science
1 publication, 3.7%
|
|
|
Organic and Biomolecular Chemistry
1 publication, 3.7%
|
|
|
Current Pharmaceutical Biotechnology
1 publication, 3.7%
|
|
|
Current Organic Synthesis
1 publication, 3.7%
|
|
|
2
4
6
8
10
|
Publishers
|
2
4
6
8
10
12
|
|
|
MDPI
11 publications, 40.74%
|
|
|
Elsevier
4 publications, 14.81%
|
|
|
Bentham Science Publishers Ltd.
3 publications, 11.11%
|
|
|
Frontiers Media S.A.
2 publications, 7.41%
|
|
|
Royal Society of Chemistry (RSC)
2 publications, 7.41%
|
|
|
Wiley
1 publication, 3.7%
|
|
|
American Chemical Society (ACS)
1 publication, 3.7%
|
|
|
Research Square Platform LLC
1 publication, 3.7%
|
|
|
Springer Nature
1 publication, 3.7%
|
|
|
IntechOpen
1 publication, 3.7%
|
|
|
2
4
6
8
10
12
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
27
Total citations:
27
Citations from 2024:
10
(37%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Zhidkov et al. Total Syntheses and Preliminary Biological Evaluation of Brominated Fascaplysin and Reticulatine Alkaloids and Their Analogues // Marine Drugs. 2019. Vol. 17. No. 9. p. 496.
GOST all authors (up to 50)
Copy
Zhidkov, Smirnova, Tryapkin, Kantemirov, Khudyakova, Malyarenko, Ermakova, Grigorchuk, Kaune, Amsberg, Dyshlovoy Total Syntheses and Preliminary Biological Evaluation of Brominated Fascaplysin and Reticulatine Alkaloids and Their Analogues // Marine Drugs. 2019. Vol. 17. No. 9. p. 496.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/md17090496
UR - https://doi.org/10.3390/md17090496
TI - Total Syntheses and Preliminary Biological Evaluation of Brominated Fascaplysin and Reticulatine Alkaloids and Their Analogues
T2 - Marine Drugs
AU - Zhidkov
AU - Smirnova
AU - Tryapkin
AU - Kantemirov
AU - Khudyakova
AU - Malyarenko
AU - Ermakova
AU - Grigorchuk
AU - Kaune
AU - Amsberg
AU - Dyshlovoy
PY - 2019
DA - 2019/08/25
PB - MDPI
SP - 496
IS - 9
VL - 17
PMID - 31450717
SN - 1660-3397
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2019_Zhidkov,
author = {Zhidkov and Smirnova and Tryapkin and Kantemirov and Khudyakova and Malyarenko and Ermakova and Grigorchuk and Kaune and Amsberg and Dyshlovoy},
title = {Total Syntheses and Preliminary Biological Evaluation of Brominated Fascaplysin and Reticulatine Alkaloids and Their Analogues},
journal = {Marine Drugs},
year = {2019},
volume = {17},
publisher = {MDPI},
month = {aug},
url = {https://doi.org/10.3390/md17090496},
number = {9},
pages = {496},
doi = {10.3390/md17090496}
}
Cite this
MLA
Copy
Zhidkov, et al. “Total Syntheses and Preliminary Biological Evaluation of Brominated Fascaplysin and Reticulatine Alkaloids and Their Analogues.” Marine Drugs, vol. 17, no. 9, Aug. 2019, p. 496. https://doi.org/10.3390/md17090496.