Open Access

Marine Drugs

, volume 19 , issue 11 , pages 610

Advances in Phenazines over the Past Decade: Review of Their Pharmacological Activities, Mechanisms of Action, Biosynthetic Pathways and Synthetic Strategies

Junjie Yan ¹

Weiwei Liu ²

Jiatong Cai ¹

Yiming Wang ¹

Dahong Li ¹

Huiming Hua ¹

Hao Cao ^{1, 3}

Hide authors affiliations Show authors affiliations: 3 affiliations

Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China |

Wuya College of innovation, Shenyang Pharmaceutical University, Shenyang 110016, China |

School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China |

Publication type: Journal Article

Publication date: 2021-10-27

MDPI

Marine Drugs

scimago Q1

wos Q1

SJR: 1.030

CiteScore: 10.1

Impact factor: 5.4

ISSN: 16603397

DOI: 10.3390/md19110610

Copy DOI

PubMed ID: 34822481

Drug Discovery

Pharmaceutical Science

Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Abstract

Phenazines are a large group of nitrogen-containing heterocycles, providing diverse chemical structures and various biological activities. Natural phenazines are mainly isolated from marine and terrestrial microorganisms. So far, more than 100 different natural compounds and over 6000 synthetic derivatives have been found and investigated. Many phenazines show great pharmacological activity in various fields, such as antimicrobial, antiparasitic, neuroprotective, insecticidal, anti-inflammatory and anticancer activity. Researchers continued to investigate these compounds and hope to develop them as medicines. Cimmino et al. published a significant review about anticancer activity of phenazines, containing articles from 2000 to 2011. Here, we mainly summarize articles from 2012 to 2021. According to sources of compounds, phenazines were categorized into natural phenazines and synthetic phenazine derivatives in this review. Their pharmacological activities, mechanisms of action, biosynthetic pathways and synthetic strategies were summarized. These may provide guidance for the investigation on phenazines in the future.

Found

1 citation

Beloglazkina Elena

DSc in Chemistry, professor

296 publications, 3 248 citations, 11 reviews

h-index: 29

Lomonosov Moscow State University

1 citation

Luponosov Yuriy

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DSc in Chemistry

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h-index: 27

Enikolopov Institute of Synthetic Polymeric Materials of the Russian Academy of Sciences

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Vil' Vera

PhD in Chemistry

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h-index: 24

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

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Organic Chemistry

1 citation

Yaremenko Ivan

PhD in Chemistry

60 publications, 1 567 citations, 5 reviews

h-index: 24

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

Research interests

Organic Chemistry

1 citation

Gorbunova Yuliya

DSc in Chemistry, professor, full member of the Russian Academy of Sciences

284 publications, 4 398 citations, 65 reviews

h-index: 34

Lomonosov Moscow State University

Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences

A.N. Frumkin Institute of Physical Chemistry and Electrochemistry of the Russian Academy of Sciences

Research interests

Coordination Chemistry

Lanthanides

Supramolecular chemistry

Tetrapyrrolic compounds

1 citation

Volcho Konstantin

DSc in Chemistry, professor of the Russian Academy of Sciences

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N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the Russian Academy of Sciences

1 citation

Danilkina Natalia

44 publications, 625 citations

h-index: 14

Saint Petersburg State University

Research interests

Bioorganic chemistry

Click chemistry

Heterocyclic compounds

Medicinal Chemistry

Organic Chemistry

1 citation

Osipov Sergey

DSc in Chemistry

138 publications, 2 739 citations, 3 reviews

h-index: 29

A.N.Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences

1 citation

Gazizov Almir

🥼

DSc in Chemistry

157 publications, 889 citations, 23 reviews

h-index: 14

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

Heterocyclic compounds

Organic Chemistry

Organophosphorus chemistry

1 citation

Karasik Andrey

DSc in Chemistry, professor, associate member of the Russian Academy of Sciences

224 publications, 2 599 citations

h-index: 26

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

Coordination Chemistry

Luminescence

Phosphorus ligands

1 citation

Dotsenko Viktor

DSc in Chemistry, professor

244 publications, 2 741 citations, 2 reviews

h-index: 22

North Caucasus Federal University

Kuban State University

Research interests

Active methylene compounds

Biological activity

Heterocyclic compounds

Malononitrile

Selenoamides

Thioamides

1 citation

Zagidullin Almaz

🥼 🤝

PhD in Chemistry

81 publications, 884 citations

h-index: 17

A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences

Research interests

Asymmetric metal complex catalysis

Chemistry of organic and organoelement compounds; chemistry of polymers; production of materials

Coordination chemistry of phosphorus

Organoelement chemistry

Organophosphorus chemistry

Synthesis of chiral phosphorus-containing ligands

1 citation

Aksenov Aleksandr

🥼 🤝

DSc in Chemistry, professor

243 publications, 2 187 citations, 15 reviews

h-index: 24

North Caucasus Federal University

Research interests

Medicinal Chemistry

Organic Chemistry

1 citation

Sosnovskikh Vyacheslav

DSc in Chemistry, professor

355 publications, 4 721 citations

h-index: 30

Ural Federal University

1 citation

Ilkin Vladimir

PhD in Chemistry

16 publications, 187 citations

h-index: 7

Ural Federal University

Research interests

Catalysis

Heterocyclic compounds

Organic Chemistry

Synthetic Organic Chemistry

1 citation

Krylov Igor

PhD in Chemistry

78 publications, 1 885 citations, 18 reviews

h-index: 25

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

Research interests

Green chemistry

Organic Chemistry

Organic electrochemistry

Organic synthesis

Photochemistry

Plant protection

1 citation

Tikhomirov Alexander

🥼 🤝

DSc in Chemistry, associate professor

59 publications, 920 citations

h-index: 17

Mendeleev University of Chemical Technology of Russia

Gause Institute of New Antibiotics

Research interests

Medicinal Chemistry

1 citation

Ivanov Andrey

54 publications, 534 citations

h-index: 12

A.E. Favorsky Irkutsk Institute of Chemistry of the Siberian Branch of the Russian Academy of Sciences

1 citation

Buev Evgeny

PhD in Chemistry

31 publications, 346 citations, 2 reviews

h-index: 9

Ural Federal University

Research interests

Chemistry of nitrogen-containing heterocycles

Organic Chemistry

Organic synthesis

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Yan J. et al. Advances in Phenazines over the Past Decade: Review of Their Pharmacological Activities, Mechanisms of Action, Biosynthetic Pathways and Synthetic Strategies // Marine Drugs. 2021. Vol. 19. No. 11. p. 610.

GOST all authors (up to 50) Copy

Yan J., Liu W., Cai J., Wang Y., Li D., Hua H., Cao H. Advances in Phenazines over the Past Decade: Review of Their Pharmacological Activities, Mechanisms of Action, Biosynthetic Pathways and Synthetic Strategies // Marine Drugs. 2021. Vol. 19. No. 11. p. 610.

RIS |

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RIS Copy

TY - JOUR

DO - 10.3390/md19110610

UR - https://doi.org/10.3390/md19110610

TI - Advances in Phenazines over the Past Decade: Review of Their Pharmacological Activities, Mechanisms of Action, Biosynthetic Pathways and Synthetic Strategies

T2 - Marine Drugs

AU - Yan, Junjie

AU - Liu, Weiwei

AU - Cai, Jiatong

AU - Wang, Yiming

AU - Li, Dahong

AU - Hua, Huiming

AU - Cao, Hao

PY - 2021

DA - 2021/10/27

PB - MDPI

SP - 610

IS - 11

VL - 19

PMID - 34822481

SN - 1660-3397

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2021_Yan,

author = {Junjie Yan and Weiwei Liu and Jiatong Cai and Yiming Wang and Dahong Li and Huiming Hua and Hao Cao},

title = {Advances in Phenazines over the Past Decade: Review of Their Pharmacological Activities, Mechanisms of Action, Biosynthetic Pathways and Synthetic Strategies},

journal = {Marine Drugs},

year = {2021},

volume = {19},

publisher = {MDPI},

month = {oct},

url = {https://doi.org/10.3390/md19110610},

number = {11},

pages = {610},

doi = {10.3390/md19110610}

}

MLA

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MLA Copy

Yan, Junjie, et al. “Advances in Phenazines over the Past Decade: Review of Their Pharmacological Activities, Mechanisms of Action, Biosynthetic Pathways and Synthetic Strategies.” Marine Drugs, vol. 19, no. 11, Oct. 2021, p. 610. https://doi.org/10.3390/md19110610.

Publisher

MDPI

Journal

Marine Drugs

scimago Q1

wos Q1

SJR

1.030

CiteScore

10.1

Impact factor

5.4

ISSN

16603397 (Print, Electronic)