Open Access
Advances in Phenazines over the Past Decade: Review of Their Pharmacological Activities, Mechanisms of Action, Biosynthetic Pathways and Synthetic Strategies
Тип публикации: Journal Article
Дата публикации: 2021-10-27
scimago Q1
wos Q1
БС1
SJR: 1.030
CiteScore: 10.1
Impact factor: 5.4
ISSN: 16603397
PubMed ID:
34822481
Drug Discovery
Pharmaceutical Science
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Краткое описание
Phenazines are a large group of nitrogen-containing heterocycles, providing diverse chemical structures and various biological activities. Natural phenazines are mainly isolated from marine and terrestrial microorganisms. So far, more than 100 different natural compounds and over 6000 synthetic derivatives have been found and investigated. Many phenazines show great pharmacological activity in various fields, such as antimicrobial, antiparasitic, neuroprotective, insecticidal, anti-inflammatory and anticancer activity. Researchers continued to investigate these compounds and hope to develop them as medicines. Cimmino et al. published a significant review about anticancer activity of phenazines, containing articles from 2000 to 2011. Here, we mainly summarize articles from 2012 to 2021. According to sources of compounds, phenazines were categorized into natural phenazines and synthetic phenazine derivatives in this review. Their pharmacological activities, mechanisms of action, biosynthetic pathways and synthetic strategies were summarized. These may provide guidance for the investigation on phenazines in the future.
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Метрики
73
Всего цитирований:
73
Цитирований c 2025:
32
(43.84%)
Цитировать
ГОСТ |
RIS |
BibTex |
MLA
Цитировать
ГОСТ
Скопировать
Yan J. et al. Advances in Phenazines over the Past Decade: Review of Their Pharmacological Activities, Mechanisms of Action, Biosynthetic Pathways and Synthetic Strategies // Marine Drugs. 2021. Vol. 19. No. 11. p. 610.
ГОСТ со всеми авторами (до 50)
Скопировать
Yan J., Liu W., Cai J., Wang Y., Li D., Hua H., Cao H. Advances in Phenazines over the Past Decade: Review of Their Pharmacological Activities, Mechanisms of Action, Biosynthetic Pathways and Synthetic Strategies // Marine Drugs. 2021. Vol. 19. No. 11. p. 610.
Цитировать
RIS
Скопировать
TY - JOUR
DO - 10.3390/md19110610
UR - https://doi.org/10.3390/md19110610
TI - Advances in Phenazines over the Past Decade: Review of Their Pharmacological Activities, Mechanisms of Action, Biosynthetic Pathways and Synthetic Strategies
T2 - Marine Drugs
AU - Yan, Junjie
AU - Liu, Weiwei
AU - Cai, Jiatong
AU - Wang, Yiming
AU - Li, Dahong
AU - Hua, Huiming
AU - Cao, Hao
PY - 2021
DA - 2021/10/27
PB - MDPI
SP - 610
IS - 11
VL - 19
PMID - 34822481
SN - 1660-3397
ER -
Цитировать
BibTex (до 50 авторов)
Скопировать
@article{2021_Yan,
author = {Junjie Yan and Weiwei Liu and Jiatong Cai and Yiming Wang and Dahong Li and Huiming Hua and Hao Cao},
title = {Advances in Phenazines over the Past Decade: Review of Their Pharmacological Activities, Mechanisms of Action, Biosynthetic Pathways and Synthetic Strategies},
journal = {Marine Drugs},
year = {2021},
volume = {19},
publisher = {MDPI},
month = {oct},
url = {https://doi.org/10.3390/md19110610},
number = {11},
pages = {610},
doi = {10.3390/md19110610}
}
Цитировать
MLA
Скопировать
Yan, Junjie, et al. “Advances in Phenazines over the Past Decade: Review of Their Pharmacological Activities, Mechanisms of Action, Biosynthetic Pathways and Synthetic Strategies.” Marine Drugs, vol. 19, no. 11, Oct. 2021, p. 610. https://doi.org/10.3390/md19110610.