Open Access

Molecules

, volume 22 , issue 1 , pages 117

Synthetic Strategies for Peroxide Ring Construction in Artemisinin

Vera Vil ^{1, 2, 3}

Ivan Yaremenko ^{1, 2, 3}

Alexey Ilovaisky ¹

Alexander Terentev ^{1, 2, 3}

Hide authors affiliations Show authors affiliations: 3 affiliations

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospekt, Moscow 119991, Russia |

Faculty of Chemical and Pharmaceutical Technology and Biomedical Products, D. I. Mendeleev University of Chemical Technology of Russia, 9 Miusskaya Square, Moscow 125047, Russia |

All-Russian Research Institute for Phytopathology, 143050 B. Vyazyomy, Moscow Region, Russia |

Publication type: Journal Article

Publication date: 2017-01-11

MDPI

Molecules

scimago Q1

wos Q2

SJR: 0.865

CiteScore: 8.6

Impact factor: 4.6

ISSN: 14203049

DOI: 10.3390/molecules22010117

Copy DOI

PubMed ID: 28085073

Organic Chemistry

Drug Discovery

Physical and Theoretical Chemistry

Pharmaceutical Science

Molecular Medicine

Analytical Chemistry

Chemistry (miscellaneous)

Abstract

The present review summarizes publications on the artemisinin peroxide fragment synthesis from 1983 to 2016. The data are classified according to the structures of a precursor used in the key peroxidation step of artemisinin peroxide cycle synthesis. The first part of the review comprises the construction of artemisinin peroxide fragment in total syntheses, in which peroxide artemisinin ring resulted from reactions of unsaturated keto derivatives with singlet oxygen or ozone. In the second part, the methods of artemisinin synthesis based on transformations of dihydroartemisinic acid are highlighted.

Found

6 citations

Vil' Vera

PhD in Chemistry

86 publications, 1 987 citations, 3 reviews

h-index: 24

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

Research interests

Organic Chemistry

5 citations

Yaremenko Ivan

PhD in Chemistry

60 publications, 1 599 citations, 5 reviews

h-index: 24

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

Research interests

Organic Chemistry

3 citations

Dzhemileva Lilya

🥼

DSc in Health sciences, associate professor

128 publications, 1 281 citations, 70 reviews

h-index: 21

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

Institute of Physiologically Active Compounds of the Russian Academy of Science

Mendeleev University of Chemical Technology of Russia

Endocrinology Research Centre

2 citations

Medvedev Alexander

PhD in Chemistry

82 publications, 2 178 citations

h-index: 24

Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences

Moscow Institute of Physics and Technology

2 citations

Radulov Peter

PhD in Chemistry

38 publications, 552 citations, 22 reviews

h-index: 14

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

Research interests

Organic Chemistry

2 citations

Medvedev Michael

PhD in Physics and Mathematics, associate professor

85 publications, 2 074 citations, 7 reviews

h-index: 19

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

2 citations

Barsegyan Yana

🥼 🤝

PhD in Chemistry

16 publications, 174 citations

h-index: 7

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

1 citation

Mulina Olga

PhD in Chemistry

33 publications, 648 citations, 4 reviews

h-index: 14

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

Research interests

Electrosynthesis

Free radicals

1 citation

Shishatskaya Ekaterina

🥼

DSc in Biological/biomedical sciences, professor, professor of the Russian Academy of Sciences

112 publications, 2 855 citations

h-index: 29

Siberian Federal University

Research interests

Biocompatibility

Biodegradation

Biopolymers - structure

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GOST |

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GOST Copy

Vil V. et al. Synthetic Strategies for Peroxide Ring Construction in Artemisinin // Molecules. 2017. Vol. 22. No. 1. p. 117.

GOST all authors (up to 50) Copy

Vil V., Yaremenko I., Ilovaisky A., Terentev A. Synthetic Strategies for Peroxide Ring Construction in Artemisinin // Molecules. 2017. Vol. 22. No. 1. p. 117.

RIS |

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RIS Copy

TY - JOUR

DO - 10.3390/molecules22010117

UR - https://doi.org/10.3390/molecules22010117

TI - Synthetic Strategies for Peroxide Ring Construction in Artemisinin

T2 - Molecules

AU - Vil, Vera

AU - Yaremenko, Ivan

AU - Ilovaisky, Alexey

AU - Terentev, Alexander

PY - 2017

DA - 2017/01/11

PB - MDPI

SP - 117

IS - 1

VL - 22

PMID - 28085073

SN - 1420-3049

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2017_Vil,

author = {Vera Vil and Ivan Yaremenko and Alexey Ilovaisky and Alexander Terentev},

title = {Synthetic Strategies for Peroxide Ring Construction in Artemisinin},

journal = {Molecules},

year = {2017},

volume = {22},

publisher = {MDPI},

month = {jan},

url = {https://doi.org/10.3390/molecules22010117},

number = {1},

pages = {117},

doi = {10.3390/molecules22010117}

}

MLA

Cite this

MLA Copy

Vil, Vera, et al. “Synthetic Strategies for Peroxide Ring Construction in Artemisinin.” Molecules, vol. 22, no. 1, Jan. 2017, p. 117. https://doi.org/10.3390/molecules22010117.

Publisher

MDPI

Journal

Molecules

scimago Q1

wos Q2

SJR

0.865

CiteScore

8.6

Impact factor

4.6

ISSN

14203049 (Print, Electronic)

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