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Molecules, том 25, издание 19, номер публикации: 4446

Hetiamacin E and F, New amicoumacin antibiotics from bacillus subtilis PJS using MS/MS-based molecular networking

Wang Ting 1, 2
Lu Qinpei 1, 2
Sun Cheng-Hang 1, 2
Lukianov Dmitrii 3
Osterman Ilya A. 3, 4
Hu Xinxin 1, 2
You Xuefu 1, 2
Liu Shaowei 1, 2
Wu Gang 1, 2
1
 
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
2
 
Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Тип документаJournal Article
Дата публикации2020-09-27
ИздательMultidisciplinary Digital Publishing Institute (MDPI)
Название журналаMolecules
Квартиль по SCImagoQ1
Квартиль по Web of ScienceQ2
Импакт-фактор 20214.93
ISSN14203049
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Краткое описание

To combat escalating levels of antibiotic resistance, novel strategies are developed to address the everlasting demand for new antibiotics. This study aimed at investigating amicoumacin antibiotics from the desert-derived Bacillus subtilis PJS by using the modern MS/MS-based molecular networking approach. Two new amicoumacins, namely hetiamacin E (1) and hetiamacin F (2), were finally isolated. The planar structures were determined by analysis of extensive NMR spectroscopic and HR–ESI–MS data, and the absolute configurations were concluded by analysis of the CD spectrum. Hetiamacin E (1) showed strong antibacterial activities against methicillin-sensitive and resistant Staphylococcus epidermidis at 2–4 µg/mL, and methicillin-sensitive and resistant Staphylococcus aureus at 8–16 µg/mL. Hetiamacin F (2) exhibited moderate antibacterial activities against Staphylococcus sp. at 32 µg/mL. Both compounds were inhibitors of protein biosynthesis demonstrated by a double fluorescent protein reporter system.

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ГОСТ |
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1. Wang T. и др. Hetiamacin E and F, New Amicoumacin Antibiotics from Bacillus subtilis PJS Using MS/MS-Based Molecular Networking // Molecules. 2020. Т. 25. № 19. С. 4446.
RIS |
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TY - JOUR

DO - 10.3390/molecules25194446

UR - http://dx.doi.org/10.3390/molecules25194446

TI - Hetiamacin E and F, New Amicoumacin Antibiotics from Bacillus subtilis PJS Using MS/MS-Based Molecular Networking

T2 - Molecules

AU - Wang, Ting

AU - Lu, Qinpei

AU - Sun, Chenghang

AU - Lukianov, Dmitrii

AU - Osterman, Ilya Andreevich

AU - Sergiev, Petr Vladimirovich

AU - Dontsova, Olga Anatolievna

AU - Hu, Xinxin

AU - You, Xuefu

AU - Liu, Shaowei

AU - Wu, Gang

PY - 2020

DA - 2020/09/27

PB - MDPI AG

SP - 4446

IS - 19

VL - 25

SN - 1420-3049

ER -

BibTex |
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@article{2020,

doi = {10.3390/molecules25194446},

url = {https://doi.org/10.3390%2Fmolecules25194446},

year = 2020,

month = {sep},

publisher = {{MDPI} {AG}},

volume = {25},

number = {19},

pages = {4446},

author = {Ting Wang and Qinpei Lu and Chenghang Sun and Dmitrii Lukianov and Ilya Andreevich Osterman and Petr Vladimirovich Sergiev and Olga Anatolievna Dontsova and Xinxin Hu and Xuefu You and Shaowei Liu and Gang Wu},

title = {Hetiamacin E and F, New Amicoumacin Antibiotics from Bacillus subtilis {PJS} Using {MS}/{MS}-Based Molecular Networking}

}

MLA
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Wang, Ting et al. “Hetiamacin E and F, New Amicoumacin Antibiotics from Bacillus Subtilis PJS Using MS/MS-Based Molecular Networking.” Molecules 25.19 (2020): 4446. Crossref. Web.