Open Access
Molecules, volume 25, issue 19, pages 4446
Hetiamacin E and F, New amicoumacin antibiotics from bacillus subtilis PJS using MS/MS-based molecular networking
Wang Ting
1, 2
,
Lu Qinpei
1, 2
,
Sun Chenghang
1, 2
,
Lukianov Dmitrii
3
,
Osterman Ilya A
3, 4
,
Sergiev Petr Vladimirovich
3, 4
,
Dontsova Olga Anatolievna
3, 4, 5
,
Hu Xinxin
1, 2
,
You Xuefu
1, 2
,
Liu Shaowei
1, 2
,
Wu Gang
1, 2
Publication type: Journal Article
Publication date: 2020-09-27
PubMed ID:
32992672
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
To combat escalating levels of antibiotic resistance, novel strategies are developed to address the everlasting demand for new antibiotics. This study aimed at investigating amicoumacin antibiotics from the desert-derived Bacillus subtilis PJS by using the modern MS/MS-based molecular networking approach. Two new amicoumacins, namely hetiamacin E (1) and hetiamacin F (2), were finally isolated. The planar structures were determined by analysis of extensive NMR spectroscopic and HR–ESI–MS data, and the absolute configurations were concluded by analysis of the CD spectrum. Hetiamacin E (1) showed strong antibacterial activities against methicillin-sensitive and resistant Staphylococcus epidermidis at 2–4 µg/mL, and methicillin-sensitive and resistant Staphylococcus aureus at 8–16 µg/mL. Hetiamacin F (2) exhibited moderate antibacterial activities against Staphylococcus sp. at 32 µg/mL. Both compounds were inhibitors of protein biosynthesis demonstrated by a double fluorescent protein reporter system.
Citations by journals
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1
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Frontiers in Microbiology
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Frontiers in Microbiology
1 publication, 7.14%
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Microorganisms
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Microorganisms
1 publication, 7.14%
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Antibiotics
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Antibiotics
1 publication, 7.14%
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Molecules
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Molecules
1 publication, 7.14%
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Marine Drugs
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Marine Drugs
1 publication, 7.14%
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Plants
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Plants
1 publication, 7.14%
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Chinese Medicine
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Chinese Medicine
1 publication, 7.14%
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Asian Journal of Organic Chemistry
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Asian Journal of Organic Chemistry
1 publication, 7.14%
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Life
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Life
1 publication, 7.14%
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ACS Omega
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ACS Omega
1 publication, 7.14%
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Microbiology
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Microbiology
1 publication, 7.14%
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Bioscience, Biotechnology and Biochemistry
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Bioscience, Biotechnology and Biochemistry
1 publication, 7.14%
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1
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Citations by publishers
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1
2
3
4
5
6
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
6 publications, 42.86%
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 7.14%
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Springer Nature
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Springer Nature
1 publication, 7.14%
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Wiley
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Wiley
1 publication, 7.14%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
1 publication, 7.14%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 7.14%
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Taylor & Francis
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Taylor & Francis
1 publication, 7.14%
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1
2
3
4
5
6
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Wang T. et al. Hetiamacin E and F, New amicoumacin antibiotics from bacillus subtilis PJS using MS/MS-based molecular networking // Molecules. 2020. Vol. 25. No. 19. p. 4446.
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Wang T., Lu Q., Sun C., Lukianov D., Osterman I. A., Sergiev P. V., Dontsova O. A., Hu X., You X., Liu S., Wu G. Hetiamacin E and F, New amicoumacin antibiotics from bacillus subtilis PJS using MS/MS-based molecular networking // Molecules. 2020. Vol. 25. No. 19. p. 4446.
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TY - JOUR
DO - 10.3390/molecules25194446
UR - https://doi.org/10.3390%2Fmolecules25194446
TI - Hetiamacin E and F, New amicoumacin antibiotics from bacillus subtilis PJS using MS/MS-based molecular networking
T2 - Molecules
AU - Lu, Qinpei
AU - Lukianov, Dmitrii
AU - Sergiev, Petr Vladimirovich
AU - Dontsova, Olga Anatolievna
AU - Hu, Xinxin
AU - Liu, Shaowei
AU - Wang, Ting
AU - Wu, Gang
AU - Sun, Chenghang
AU - Osterman, Ilya A
AU - You, Xuefu
PY - 2020
DA - 2020/09/27 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 4446
IS - 19
VL - 25
PMID - 32992672
SN - 1420-3049
ER -
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@article{2020_Wang,
author = {Qinpei Lu and Dmitrii Lukianov and Petr Vladimirovich Sergiev and Olga Anatolievna Dontsova and Xinxin Hu and Shaowei Liu and Ting Wang and Gang Wu and Chenghang Sun and Ilya A Osterman and Xuefu You},
title = {Hetiamacin E and F, New amicoumacin antibiotics from bacillus subtilis PJS using MS/MS-based molecular networking},
journal = {Molecules},
year = {2020},
volume = {25},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {sep},
url = {https://doi.org/10.3390%2Fmolecules25194446},
number = {19},
pages = {4446},
doi = {10.3390/molecules25194446}
}
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MLA
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Wang, Ting, et al. “Hetiamacin E and F, New amicoumacin antibiotics from bacillus subtilis PJS using MS/MS-based molecular networking.” Molecules, vol. 25, no. 19, Sep. 2020, p. 4446. https://doi.org/10.3390%2Fmolecules25194446.