Open Access
New Halogen-Containing Drugs Approved by FDA in 2021: An Overview on Their Syntheses and Pharmaceutical Use
Publication type: Journal Article
Publication date: 2022-03-02
PubMed ID:
35268744
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
This review describes the recent Food and Drug Administration (FDA)-approved drugs (in the year 2021) containing at least one halogen atom (covalently bound). The structures proposed throughout this work are grouped according to their therapeutical use. Their synthesis is presented as well. The number of halogenated molecules that are reaching the market is regularly preserved, and 14 of the 50 molecules approved by the FDA in the last year contain halogens. This underlines the emergent role of halogens and, in particular, of fluorine and chlorine in the preparation of drugs for the treatment of several diseases such as viral infections, several types of cancer, cardiovascular disease, multiple sclerosis, migraine and inflammatory diseases such as vasculitis.
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120
Total citations:
120
Citations from 2024:
83
(69%)
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GOST
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Benedetto Tiz D. et al. New Halogen-Containing Drugs Approved by FDA in 2021: An Overview on Their Syntheses and Pharmaceutical Use // Molecules. 2022. Vol. 27. No. 5. p. 1643.
GOST all authors (up to 50)
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Benedetto Tiz D., Bagnoli L., Rosati O., Marini F., Sancineto L., Santi C. New Halogen-Containing Drugs Approved by FDA in 2021: An Overview on Their Syntheses and Pharmaceutical Use // Molecules. 2022. Vol. 27. No. 5. p. 1643.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/molecules27051643
UR - https://doi.org/10.3390/molecules27051643
TI - New Halogen-Containing Drugs Approved by FDA in 2021: An Overview on Their Syntheses and Pharmaceutical Use
T2 - Molecules
AU - Benedetto Tiz, Davide
AU - Bagnoli, Luana
AU - Rosati, Ornelio
AU - Marini, Francesca
AU - Sancineto, Luca
AU - Santi, Claudio
PY - 2022
DA - 2022/03/02
PB - MDPI
SP - 1643
IS - 5
VL - 27
PMID - 35268744
SN - 1420-3049
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2022_Benedetto Tiz,
author = {Davide Benedetto Tiz and Luana Bagnoli and Ornelio Rosati and Francesca Marini and Luca Sancineto and Claudio Santi},
title = {New Halogen-Containing Drugs Approved by FDA in 2021: An Overview on Their Syntheses and Pharmaceutical Use},
journal = {Molecules},
year = {2022},
volume = {27},
publisher = {MDPI},
month = {mar},
url = {https://doi.org/10.3390/molecules27051643},
number = {5},
pages = {1643},
doi = {10.3390/molecules27051643}
}
Cite this
MLA
Copy
Benedetto Tiz, Davide, et al. “New Halogen-Containing Drugs Approved by FDA in 2021: An Overview on Their Syntheses and Pharmaceutical Use.” Molecules, vol. 27, no. 5, Mar. 2022, p. 1643. https://doi.org/10.3390/molecules27051643.