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Publications found: 12371
Q2

Determination of KGa‐1b and SHCa‐1 Δ′17O and δ18O via Laser Fluorination of Lithium Fluoride Clay Pellets
Gagnon C., Havel R., Chen J., Piccione G., Ibarra D.
ABSTRACTRationaleStable oxygen isotope measurements in silicate clays, such as smectite and kaolinite, provide crucial information for understanding Earth's climate history and environmental changes. Despite a growing interest in the oxygen isotope analysis of silicate clays and clay‐rich sediments, there lacks a consensus on the preparation and standardization of clay mineral samples. To improve the accuracy and interlaboratory comparisons of clay isotope measurements, especially those involving laser fluorination techniques, newly established kaolinite and smectite oxygen isotope standards are much needed.MethodsWe employed conventional nickel bomb fluorination combined with dual‐inlet isotope ratio mass spectrometry to establish precise δ18O and Δ′17O values for leached clay reference materials KGa‐1b and SHCa‐1, a kaolinite and a hectorite/smectite, respectively. We further measured leached KGa‐1b and SHCa‐1 pressed into pellets with a lithium fluoride as a binding agent for the laser fluorination method, allowing us to test the reproducibility between methods and utilize a standard laser chamber drift correction scheme.ResultsThe laser fluorination technique yielded highly precise and reproducible δ18O and Δ′17O measurements for the KGa‐1b and SHCa‐1, aligning with bomb values of δ18O. This confirms the method's reliability and comparability to conventional isotope measurement techniques while also stressing the importance of proper sample preparation and laser chamber drift corrections.ConclusionsThis study demonstrates that laser fluorination is an effective method for accurately measuring the stable oxygen isotope composition of silicate clays or clay‐rich sediments when corrected with known silicate clay standards. These methods offer a valuable methodology for future research and applications that will significantly improve our understanding of past climate and environmental conditions.
Q2

Rapid Proteomic Amelogenin Sex Estimation of Human and Cattle Remains Using Untargeted Evosep‐timsTOF Mass Spectrometry
Blacka C., Dowle A., Lisowski M., Alexander M., Hendy J., Penkman K., Mosely J.
ABSTRACTRationaleSex estimation by analysis of amelogenin peptides in archaeological and fossil material has recently been gaining great traction within the fields of archaeology and palaeontology. Current widely used proteomic amelogenin sex estimation methods are hindered by relatively long mass spectrometric run times, or targeting peptides specific to human amelogenin proteins. Untargeted, high‐throughput amelogenin sexing would be invaluable for a range of applications, from sex estimation of remains at mass grave sites to broadening the application of rapid amelogenin sexing to non‐hominin species for husbandry and evolutionary studies.MethodsA new acid etch protocol followed by Evosep‐LC‐TIMS‐TOF mass spectrometry is presented for amelogenin analysis, providing global peptide data through rapid mass spectrometric methods in under 20 min per sample (including sample preparation, mass spectrometric acquisition and data processing). This sampling protocol was developed on modern cattle (Bos taurus) teeth, before Evosep‐timsTOF partial validation with archaeological cattle and human (Homo sapiens) teeth, demonstrating the potential of straightforward application of this rapid amelogenin sexing method to a range of taxa.ResultsThe rapid Evosep‐LC‐TIMS‐TOF mass spectrometry methods gave comparable peptide counts to conventional long untargeted methods, while maintaining similar (or faster) acquisition times to those reported in methods targeting specific human amelogenin peptides. Implementation of the novel acid etch sampling approach also streamlined sample preparation without compromising peptide counts.ConclusionsRapid, untargeted Evosep‐LC‐TIMS‐TOF mass spectrometry was successfully implemented in sex estimation of modern and archaeological material from Bos taurus and Homo sapiens teeth. This demonstrates an advancement in low‐cost, high‐throughput amelogenin sex estimation, for both human and zooarchaeological applications.
Q2

Determination of K Isotope Compositions in Sedimentary Rocks and Their Implications for Discriminating Sediment Origin
Cui M., Moynier F., Su B., Hu Y.
ABSTRACTThe advent of a new generation of collision‐cell multicollector inductively‐coupled‐plasma mass‐spectrometers (CC–MC–ICP–MS), the Nu sapphire, has provided a new venue in achieving higher precision K isotopic compositions compared to the older generation of instruments. Here, we take advantage of this new technology to report the K isotopic compositions of eight sediment reference materials. The K isotopic compositions (reported as the δ41K representing the 41K/39K ratios) for these sediment reference materials span a range of 0.2‰: −0.42 ± 0.04‰ (BCSS‐1), −0.51 ± 0.07‰ (MESS‐1), and −0.43 ± 0.01‰ (MESS‐4) for three marine sediments, −0.35 ± 0.07‰ (NIST‐SRM 1646a) for estuarine sediment, −0.40 ± 0.06‰ (NIST‐SRM 2704) and −0.40 ± 0.05‰ (SWR‐3) for two river sediments, −0.55 ± 0.04‰ (NIST‐SRM 1d) for limestone, and −0.46 ± 0.00‰ (SBC‐1) for marine shale. The high‐precision K isotopic data presented herein provide a valuable reference for future quality control and interlaboratory comparisons. Data compilation reveals that biogenic sediments show extremely low K concentrations (K2O = 0.001–0.048 wt.%) and large K isotopic variations (δ41K = −1.88–0.94‰) with an average value of −0.001‰, whereas the abiogenic sediments are featured with light K isotopes (average δ41K value of −0.47‰) and high K concentrations (K2O = 0.52 ~ 4.29 wt.%). This finding suggests that the variation of K isotopes may serve as a useful tool for discriminating the various geneses of sediments.
Q2

Carbon and Nitrogen Isotopic Composition of Duplicate Diet of the Japanese
Yoshinaga J.
ABSTRACTRationaleCarbon and nitrogen stable isotope ratios (δ13C and δ15N) of whole diet have rarely been measured to date though the isotope ratios in human sample have been extensively used for diet and nutritional researches. In order to fully validate the isotope dietary analysis, isotopic information of whole diet is required.Methodsδ13C and δ15N of 150 duplicate diet samples collected in Japan during 2016–2017 were measured. Sixty‐five males and 85 females (mean age: 45 years) donated duplicate diet sample of which δ13C and δ15N were measured by element analyzer‐isotope ratio mass spectrometry.ResultsMean δ13C and δ15N of the 150 duplicate diets were −24.3 (1.1) ‰ and 3.58 (0.93) ‰, respectively, with no gender‐ and age‐dependent variation. δ15N of diet containing seafood (median: 3.60‰, n = 111) was significantly more elevated than that not containing seafood (3.01‰, n = 39). δ15N of Japanese diet is decreasing from 1990s to the present, which is consistent with the national statistics showing decreasing trend of seafood consumption of the Japanese. Contradictory to these observation, dietary δ15N was not elevated in diet samples from the elderlies though the diet of elderlies contained seafood more frequently than those of younger study participants.ConclusionThere were some uncertainties as to whether seafood is a major determinant of dietary δ15N of the Japanese. To further characterize dietary components that determine δ values, isotope ratio analysis of diet of known quantitative dietary components is warranted.
Q2

Combination of Metabolite Analysis and Network Pharmacology to Explore the Potential Anticough Mechanism of Protopine—A Marker in Zhi‐Ke‐Bao Tablets
Zou Q., Chen D., Liu C., Chen Z., Yang X., Xu R., Zhou Z., Chen J., Shi W., Zhang F.
ABSTRACTRationaleProtopine, an active alkaloid in Papaver somniferum L., was abundant in a well‐known anticough traditional Chinese medicine preparation—Zhi‐Ke‐Bao tablets. Till now, the metabolism feature and anticough mechanism of protopine have not been fully elucidated, restricting its further development.MethodsThe metabolites of protopine in rats were profiled by using ultra‐high performance liquid chromatography coupled with time‐of‐flight mass spectrometry, and its anticough targets and mechanism were predicted by network pharmacology.ResultsIn rats, a total of 19 metabolites were identified following ingestion of protopine (21 mg/kg/day, i.g.), including 4 in plasma, 6 in urine, 5 in feces, 10 in liver, 2 in spleen, 4 in lung, 3 in kidney, 3 in heart, and 3 in brain. The main metabolic features were ring‐opening, methylation, demethylation, glucuronidation, sulfation, and hydroxylation. Among them, methylation, sulfation, and hydroxylation of protopine in vivo were revealed for the first time. The network pharmacology results show that protopine and its metabolites regulate physiological activities by acting on STAT3, SRC, CASP3, MTOR, MMP9, ESR1, and other targets, involving PI3K‐Akt signaling pathway, FoxO signaling pathway, and TNF signaling pathway, etc.ConclusionsThe metabolic features of protopine and its potential mechanisms for anticough effects were outlined, providing data for further anticough pharmacological validation of protopine.
Q2

Fast Pyrolysis of Cigarette and Cigar Leaves: Differential Analysis of Their Heavy Products by Ultrahigh‐Resolution Mass Spectrometry
Zhu Z., Zhang C., Shi Y., Zou P., Ding N., Zong K., Jia L., Guo D.
ABSTRACTRationaleThe cigars have characteristic flavors in smoke when compared with cigarettes, and cigars from various origins also have a difference in taste. However, little information can be found about the difference in chemical components of smokes between cigar and cigarette as well as between cigars, so it is interesting to compare their pyrolysis product distribution.MethodsThe cigarette and cigar leaves were pyrolyzed in a microfluidized‐bed reactor, and the pyrolysis vapors were condensed and collected using cold traps. Mass spectrometric analysis of condensed liquids was performed utilizing electrospray ionization‐orbitrap mass spectrometry in both positive and negative ion modes.ResultsThe mass spectra of condensable pyrolysis products of three tobacco leaves were obtained by Orbitrap‐MS in both positive and negative ESI modes. The DBE values (to carbon atom number) and the relative distribution (to nitrogen or oxygen atom number) of different products were carefully compared and discussed.ConclusionThe main difference in pyrolysis products between cigarette and cigar leaves relates to N1–N2 class compounds in high‐mass range as well as highly unsaturated nitrogenated compounds, while the one between two cigar leaves is associated with CxHyOzN5–9 and C30‐50HyOzNw compounds. Besides, the oxygenated products that fall into the H/C > 2 and O/C < 1 ranges are also characteristic for Dominican cigar.
Q2

Pioneering Mass Spectrometry: A Tribute to My Mentor Jean‐François Muller and His Enduring Legacy
Frache G.
ABSTRACTProfessor Jean‐François Muller, a distinguished figure in the field of mass spectrometry, made significant contributions to the advancement of analytical chemistry and its applications. As the founding director of the Laboratory of Mass Spectrometry and Laser Chemistry at the University of Metz, Muller played a pivotal role in establishing Metz as a leading center for mass spectrometry research. His pioneering work, particularly in the development of matrix‐assisted laser desorption/ionization (MALDI) instrumentation and Fourier transform ion cyclotron resonance mass Spectrometry (FTICR MS), has had a profound impact on various scientific disciplines. This article commemorates Professor Muller's illustrious career and highlights his collaborative efforts with industrial partners such as Total, which led to groundbreaking advancements in MS analysis. I will delve into the key findings of my thesis which focused on instrumental developments for MALDI analysis and imaging, as well as personal reminiscences and the impact of his inspiring mentorship.
Q2

Systematic Analysis of the Chemical Components of Gentiana urnula Harry Sm Using SIRIUS and Liquid Chromatography High‐Resolution Mass Spectrometry
Yan Z., Ning J., Luo Z., Li D., Wang H., Xie X.
ABSTRACTRationaleGentiana urnula Harry Sm is a frequently utilized traditional Chinese medicine (TCM) with applications in the treatment of a range of ailments including jaundice, gastrointestinal ulcers, and influenza. Despite its widespread uses, there is a lack of comprehensive researches on the chemical composition.MethodsThis study integrated SIRIUS, quantitative structure‐retention relationship (QSRR), and liquid chromatography high‐resolution mass spectrometry (LC‐HRMS) to identify the compounds in Gentiana urnula Harry Sm.ResultsA total of 213 compounds were identified with high confidence based on retention time (tR), MS1, and MS/MS. Among the 213 compounds, 26 compounds were positively identified firstly in Gentiana urnula Harry Sm. More than 5000 compounds were classified based on MS/MS. Spatial distribution revealed the similarities in compound between roots and stems, while differences were observed between leaves and flowers.ConclusionsThis study lays the foundation for further investigations into the biological activity and pharmacological mechanism of Gentiana urnula Harry Sm.
Q2

Part B: SLICE‐MSI—A Machine Learning Interface for System Suitability Testing of Mass Spectrometry Imaging Platforms
Kibbe R., Mills Q., Sohn A., Muddiman D.
ABSTRACTRationaleThe field of mass spectrometry imaging is currently devoid of standardized protocols or commercially available products designed for system suitability testing of MSI platforms. Machine learning is an approach that can quickly and effectively identify complex patterns in data and use them to make informed classifications, but there is a technical barrier to implementing these algorithms. Here we package the machine learning algorithms into a user‐friendly interface to make community‐wide implementation of this protocol possible.MethodsThe software package is built entirely in the Python language using the PySimpleGUI library for the construction of the interface, Pandas and Numpy libraries for data formatting and manipulation, and the Scikit‐Learn library for the implementation of machine learning algorithms. Training data is collected on an instrument under clean and compromised conditions that can then be used to evaluate model performance and to train models prior to interrogating unknown samples before, during, or after experiments.ResultsDetailed instructions are provided for the effective use of the SLICE‐MSI software package to use machine learning to evaluate instrument condition of MSI platforms. File formatting and generalizable steps are clearly described to make the implementation of this package easy for multiple labs and different MSI platform configurations.ConclusionsIn this protocol, we demonstrate SLICE‐MSI, a machine learning graphical user interface for efficient and easy implementation of QC instrument classification of mass spectrometry imaging platforms.
Q2

Part A: Implementing an Analyte Panel and Sampling Protocol for Quality Control in Mass Spectrometry Imaging
Mills Q., Kibbe R., Sohn A., Percy A., Backiel K., Muddiman D.
ABSTRACTRationaleWhile quality control (QC) and system suitability testing (SST) methods are commonly employed in mass spectrometry, the field of mass spectrometry imaging (MSI) currently lacks any universally accepted QC/SST protocols. These methods can prevent the loss of precious samples due to suboptimal instrument conditions and/or data quality, but they are more challenging to implement on MSI platforms. Herein, a panel of analytes is conveniently analyzed in a setup that reflects a typical MSI imaging experiment, and guidance is provided for downstream QC/SST evaluation.MethodsThe analyte panel will be commercially available and consists of three pairs of unlabeled (NAT) analytes and their stable isotope–labeled (SIL) analogues; a deviation from the standard procedure is also included, which incorporates a polymer to expand m/z coverage. The NAT three‐plex (or four‐plex with the added polymer) is analyzed as a droplet on a slide, and the SIL three‐plex is doped into the electrospray solvent, isolating the NAT and SIL compounds to different source components. Datasets are collected on clean and compromised instruments to inform QC/SST software and later evaluate instrument conditions or isolated metrics of data quality.ResultsA procedure was created for QC/SST analysis on MSI platforms, which can be optionally paired with the freely available software Supervised Learning for Instrument Classification and Evaluation for Mass Spectrometry Imaging (SLICE‐MSI) to classify the condition of the instrument. The SIL data may be monitored separately during imaging experiments for continuous evaluation of electrospray stability. The protocol highlights areas that may be adapted for other ionization sources for widespread use.ConclusionsThe protocol described herein uses a panel of NAT and SIL compounds to offer an objective and accurate determination of QC/SST on MSI platforms.
Q2

Determination of Collisional Cross Section Using Microscale High‐Field Asymmetric Waveform ion Mobility Spectroscopy–Mass Spectrometry (FAIMS‐MS)
Krasnova K., Creaser C., Reynolds J.
ABSTRACTRationaleCollisional cross sections (CCS) are an important characteristic of gas‐phase ions that are measured using ion mobility‐mass spectrometry (IMS). Typically, CCS measurements are performed with drift‐tube IMS or travelling‐wave IMS. However. in a high‐field asymmetric waveform ion mobility (FAIMS) device, ion heating effects make CCS determination more challenging. This research explores whether CCS can be predicted with microscale FAIMS by using known CCS standards.MethodsAn Owlstone ultraFAIMS microscale FAIMS spectrometer was coupled to an Orbitrap Exactive mass spectrometer. Two different CCS standard mixtures (tetraalkylammonium halides [TAAHs] and poly‐DL‐alanine oligomers) were used to evaluate the system's potential to determine CCS. Test peptide bradykinin acetate and substance P were used to evaluate CCS determination accuracy for singly and doubly charged peptide species using external calibration with a series of poly‐DL‐alanine peptides for +1, +2 charge states.ResultsCalibrations with excellent correlation coefficients (R2 = 0.99) for both TAAHs and poly‐DL‐alanine were obtained. Good accuracy of determination was achieved for bradykinin [M + 2H]2+ with a ± 0.5% difference between experimental and published CCS at a dispersion field (DF) strength of 250 Td; the model proved less accurate for bradykinin [M + H]+ (±1.4% at 240 Td). The accuracy of determination for the [M + H]+ and [M + 2H]2+ ions of substance P was within ± 5% and ± 3% at 250 Td, respectively, while at higher DF values, accuracy decreased to approximately 5%.ConclusionsDistinct relationships were observed between CCS and transmission CF with both calibrants. Optimum accuracy was obtained at DF 240–260 Td. At lower DF, accuracy is reduced by insufficient resolution of analyte ions from solvent cluster adducts, while at higher DF values, poor transmission becomes a factor. Nevertheless, these data suggest microscale FAIMS can conduct CCS measurements with reasonable accuracy when the compound being measured has similar structural features to the CCS standards used.
Q2

Improved Protective Effects and Pharmacokinetics of Huperzine A Derivative H14 in Soman Poisoning: A Comparative Study With Huperzine A in Rats
Yang G., Cui Y., Zong X., Jin Q., Zhang Y., Li L., Liu D., Chen X., Wang C., Wei J.
ABSTRACTRationaleN‐[2‐Hydroxy‐3,5‐dimethylbenzilidene]‐Hup A (H14) is a derivative of huperzine A (Hup A) that demonstrates superior protective effects against soman (GD) compared to Hup A. This study aims to evaluate the protective efficacy of H14 pretreatment against GD in rats and to provide an analytical framework for the pharmacokinetic evaluation of H14 in experimental animals.MethodsThe study employed protective ratios (PR) as an evaluation criterion to assess the efficacy of H14 and Hup A in preventing GD in vivo. Liquid–liquid extraction techniques were utilized to extract H14 and its metabolite, Hup A, from plasma. The extracted plasma samples were then analyzed using an ultra‐high‐performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) method for the simultaneous quantification of H14 and Hup A.ResultsThe PR values for the 6‐ and 12‐h Hup A groups were 1.26 and 1.08, respectively. In contrast, the 6, 12, and 24‐h H14 groups demonstrated PR values of 2.81, 1.98, and 1.18, respectively, indicating extended protective capabilities compared to Hup A. All validation parameters for the UHPLC–MS/MS method, including linearity, specificity, precision, accuracy, matrix effect, and stability, met the acceptance criteria established by FDA guidelines. The pharmacokinetic analysis indicates that H14, after conversion to Hup A in vivo, significantly extends the duration of Hup A concentrations in the body, leading to more effective prevention of GD poisoning compared to Hup A alone.ConclusionsH14 demonstrates superior efficacy in preventing GD poisoning compared to Hup A. Furthermore, this analytical approach offers a reliable and efficient method for the pharmacokinetic evaluation of H14 in experimental animals.
Q2

Covalent Organic Framework Nanofilm‐Assisted Laser Desorption Ionization Mass Spectrometry for the Determination of Benzophenone Derivatives in Personal Care Products
Yan L., Zheng W., Lin Z.
ABSTRACTRationalBenzophenone derivatives, commonly used as UV filters in personal care products (PCPs), are widely prevalent and raise concerns due to their endocrine‐disrupting effects. Sensitive and efficient analytical methods are in demand for their detection. In this study, we developed a TAPB‐DMTP‐covalent organic framework (COF) nanofilm‐assisted laser desorption ionization mass spectrometry (LDI‐MS) method for the quantitative analysis of 2,4‐dihydroxybenzophenone (BP‐1) in PCPs.MethodsThe TAPB‐DMTP‐COF nanofilm was synthesized on indium tin oxide (ITO) glass and utilized as an LDI‐MS substrate. The performance of TAPB‐DMTP‐COF nanofilm‐assisted LDI‐MS for analyzing small molecules (e.g., benzophenone derivatives, phthalates, amino acids, sugars, and nucleosides) was compared to conventional organic matrices (α‐cyano‐4‐hydroxycinnamic acid [CHCA], 2,5‐dihydroxybenzoic acid [DHB], and sinapinic acid [SA]). The reproducibility, salt resistance, sensitivity, and stability of the method were further evaluated. Finally, the technique was applied to quantify BP‐1 in PCPs.ResultsThe TAPB‐DMTP‐COF nanofilm‐assisted LDI‐MS provided stronger mass spectral signals and cleaner backgrounds for small molecules compared to CHCA, DHB, and SA. The method exhibited high reproducibility (RSD = 6.10%) and stability for up to 30 days. BP‐1 in PCPs was quantified with excellent linearity (1–20 μg/mL, r = 0.9993), a low detection limit (0.3 μg/mL), and recovery rates of 94.2%–104.4%, demonstrating the potential of TAPB‐DMTP‐COF nanofilm for sensitive and reliable small‐molecule analysis.ConclusionTAPB‐DMTP‐COF nanofilm‐assisted LDI‐MS offered the advantages of rapid analysis, clean backgrounds, and reproducibility for detecting small molecules, including benzophenone derivatives. This method successfully quantified BP‐1 in PCPs, highlighting its suitability for analyzing complex samples.
Q2

Assessing Matrix and Nonmatrix, Single, and Multipoint Calibration of Trace Elements Using LA‐ICP‐MS on a Tropical Speleothem
Sekhon N., Gao A., Mallick S., Partin J., Cardenas M. ., Ibarra D.
ABSTRACTRationaleSuites of trace elements are routinely used in speleothems as proxies to understand periods of past climate change. Laser ablation techniques are regularly implemented to acquire high resolution (50‐μm) trace element concentrations in carbonate archives for paleoclimatology. There exists limited research investigating Laser Ablation‐Inductively Coupled Plasma‐Mass Spectrometry (LA‐ICP‐MS) protocols using speleothem samples. This study investigates the difference between using matrix (carbonate) and nonmatrix (silicate) matched reference materials and the utility of 1‐point versus multiple point calibration curves.MethodsFollowing an extensive review of published literature on speleothem LA‐ICP‐MS analyses, we conducted two laser ablation experimental runs 8 months apart on a 2.7‐cm section of a natural speleothem using matrix and nonmatrix matched reference materials. We used a 193‐nm wavelength Analyte G2 laser attached to a X‐Series‐2 ICP‐MS, a silicate reference material, and three carbonate reference materials. Next, we calculated concentrations using a 1‐point calibration curve, a 2‐point calibration curve, and a 3‐point calibration curve.ResultsThe analysis of matrix and nonmatrix matched reference materials demonstrates that the trends of trace elements/Ca are minimally impacted by the matrix material of the standard. We also show that 2‐ and 3‐point calibration curves bracket the range of sample concentrations compared to a 1‐point (silicate) calibration curve. The calculated cave‐air temperatures using Mg/Ca concentrations fall within error of each other regardless of the calibration curve approach applied.ConclusionsOur experiments provide a proof of concept on the conventional setup of standards during LA‐ICP‐MS speleothem analysis. We suggest the use of at minimum a 2‐point (silicate plus carbonate or carbonates) calibration curve that crucially bracket the range of sample concentrations rather than relying on a 1‐point silicate standard that does not bracket the sample concentration. Finally, our results have implications for both speleothem studies that use LA‐ICP‐MS analytical techniques and additional carbonate archives.
Q2

Exploration of Active Substances and Its Potential Mechanism of Gancao Fuzi Decoction on Inflammatory Based on Metabolomics and Network Pharmacology
Geng W., Liu S., Dong H., Arachchige B., Qi D., Wang X.
ABSTRACTGancao Fuzi decoction (GCFZT) is a traditional Chinese formula, which has been commonly used in clinical practice to treat inflammatory diseases. However, the active substance of GCFZT in the treatment of inflammation is not fully clarified. In this study, we used orthogonal experiments to design different GCFZT formulations, resulting in a total of 16 GCFZT formulations. Subsequently, UPLC‐Q‐TOF‐MS/MS was used to analyze the chemical composition of different formulations, and the anti‐inflammatory activity differences of these formulations were evaluated through an LPS‐induced RAW264.7 inflammatory cell model. Combined with machine learning algorithms such as PLS‐DA and RF, four main active substances in GCFZT were screened. Finally, network pharmacology techniques were used to investigate the potential anti‐inflammatory mechanisms of these main active substances, and the results showed that GCFZT mainly regulates the expression of core targets such as ALOX5, NFKB1, and TLR4 through main active substances such as chlorogenic acid, riboflavin, and formononetin, thereby affecting the NF kappa B signaling pathway, the Toll‐like receptor signaling pathway, and the Th17 cell differentiation. This study provides a reference for the anti‐inflammatory mechanism of GCFZT and a scientific basis for its clinical application.
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Journal of Composites Science
4 citations, 0.21%
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Angewandte Chemie
4 citations, 0.21%
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Journal of Polymer Science
4 citations, 0.21%
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Batteries & Supercaps
4 citations, 0.21%
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Advanced Synthesis and Catalysis
3 citations, 0.16%
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Clean Technologies and Environmental Policy
3 citations, 0.16%
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Catalysis in Industry
3 citations, 0.16%
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IOP Conference Series: Earth and Environmental Science
3 citations, 0.16%
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Frontiers in Chemistry
3 citations, 0.16%
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Chemistry of Materials
3 citations, 0.16%
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Separation Science and Technology
3 citations, 0.16%
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ChemistrySelect
3 citations, 0.16%
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Citing publishers
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Elsevier
620 citations, 32.87%
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MDPI
364 citations, 19.3%
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Springer Nature
229 citations, 12.14%
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Wiley
159 citations, 8.43%
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Royal Society of Chemistry (RSC)
129 citations, 6.84%
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American Chemical Society (ACS)
122 citations, 6.47%
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Taylor & Francis
37 citations, 1.96%
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Institute of Electrical and Electronics Engineers (IEEE)
24 citations, 1.27%
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Frontiers Media S.A.
19 citations, 1.01%
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IOP Publishing
15 citations, 0.8%
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SAGE
10 citations, 0.53%
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Pleiades Publishing
9 citations, 0.48%
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Walter de Gruyter
8 citations, 0.42%
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The Electrochemical Society
8 citations, 0.42%
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American Society of Civil Engineers (ASCE)
6 citations, 0.32%
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Emerald
5 citations, 0.27%
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Bentham Science Publishers Ltd.
5 citations, 0.27%
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Trans Tech Publications
5 citations, 0.27%
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AIP Publishing
5 citations, 0.27%
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Korean Society of Industrial Engineering Chemistry
3 citations, 0.16%
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Cold Spring Harbor Laboratory
3 citations, 0.16%
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Kalvis
3 citations, 0.16%
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Bulletin of Chemical Reaction Engineering and Catalysis
3 citations, 0.16%
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EDP Sciences
2 citations, 0.11%
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American Association for the Advancement of Science (AAAS)
2 citations, 0.11%
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Center of Biomass and Renewable Energy Scientia Academy
2 citations, 0.11%
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Beilstein-Institut
2 citations, 0.11%
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Science in China Press
2 citations, 0.11%
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Hindawi Limited
2 citations, 0.11%
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Canadian Science Publishing
2 citations, 0.11%
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Oriental Scientific Publishing Company
2 citations, 0.11%
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SciELO
2 citations, 0.11%
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Research Square Platform LLC
2 citations, 0.11%
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World Scientific
1 citation, 0.05%
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Georg Thieme Verlag KG
1 citation, 0.05%
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King Saud University
1 citation, 0.05%
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The Royal Society
1 citation, 0.05%
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Public Library of Science (PLoS)
1 citation, 0.05%
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American Institute of Mathematical Sciences (AIMS)
1 citation, 0.05%
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Scientific Publishers
1 citation, 0.05%
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Korean Society of Environmental Engineers
1 citation, 0.05%
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Ivanovo State University of Chemistry and Technology
1 citation, 0.05%
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Portland Press
1 citation, 0.05%
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Universidade Federal do Rio de Janeiro
1 citation, 0.05%
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Tsinghua University Press
1 citation, 0.05%
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Chinese Academy of Sciences
1 citation, 0.05%
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Wageningen Academic Publishers
1 citation, 0.05%
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American Society of Animal Science
1 citation, 0.05%
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Lviv Polytechnic National University
1 citation, 0.05%
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Saint-Petersburg Mining University
1 citation, 0.05%
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International Association for Food Protection
1 citation, 0.05%
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1 citation, 0.05%
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Japan Association of Solvent Extraction
1 citation, 0.05%
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Kemerovo State University
1 citation, 0.05%
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Asian Journal of Chemistry
1 citation, 0.05%
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S K Press V.O.S.
1 citation, 0.05%
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Medknow
1 citation, 0.05%
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Annual Reviews
1 citation, 0.05%
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ASME International
1 citation, 0.05%
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Thomas Telford
1 citation, 0.05%
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Social Science Electronic Publishing
1 citation, 0.05%
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Centre for Evaluation in Education and Science (CEON/CEES)
1 citation, 0.05%
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IGI Global
1 citation, 0.05%
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IntechOpen
1 citation, 0.05%
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World Scientific and Engineering Academy and Society (WSEAS)
1 citation, 0.05%
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Tecno Scientifica Publishing
1 citation, 0.05%
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Publishing organizations
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University of York
5 publications, 3.29%
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University of Porto
4 publications, 2.63%
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University of Bath
3 publications, 1.97%
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Central Salt and Marine Chemicals Research Institute
2 publications, 1.32%
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Ural Federal University
1 publication, 0.66%
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University of Delhi
1 publication, 0.66%
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Indian Institute of Technology Madras
1 publication, 0.66%
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Indian Institute of Technology Guwahati
1 publication, 0.66%
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Jawaharlal Nehru University
1 publication, 0.66%
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Banaras Hindu University
1 publication, 0.66%
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Aligarh Muslim University
1 publication, 0.66%
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Indian Institute of Chemical Technology
1 publication, 0.66%
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University of Allahabad
1 publication, 0.66%
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Amity University, Noida
1 publication, 0.66%
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Amity University, Gurgaon
1 publication, 0.66%
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Vignan's Foundation for Science, Technology & Research
1 publication, 0.66%
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Gandhi Institute of Technology and Management
1 publication, 0.66%
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Qatar University
1 publication, 0.66%
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Umeå University
1 publication, 0.66%
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Lulea University of Technology
1 publication, 0.66%
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Polytechnic University of Milan
1 publication, 0.66%
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University of Bologna
1 publication, 0.66%
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Åbo Akademi University
1 publication, 0.66%
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National University of Singapore
1 publication, 0.66%
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University of Salerno
1 publication, 0.66%
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Roma Tre University
1 publication, 0.66%
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Royal Melbourne Institute of Technology
1 publication, 0.66%
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Arizona State University
1 publication, 0.66%
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North Carolina State University
1 publication, 0.66%
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Lawrence Livermore National Laboratory
1 publication, 0.66%
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Osaka University
1 publication, 0.66%
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Hunan University
1 publication, 0.66%
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Federal University of São Carlos
1 publication, 0.66%
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National Technical University of Athens
1 publication, 0.66%
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University of West Attica
1 publication, 0.66%
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National Hellenic Research Foundation
1 publication, 0.66%
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McMaster University
1 publication, 0.66%
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Universidad de León
1 publication, 0.66%
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Leuphana University of Lüneburg
1 publication, 0.66%
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Johannes Gutenberg University Mainz
1 publication, 0.66%
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Mie University
1 publication, 0.66%
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Saitama University
1 publication, 0.66%
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University of Coimbra
1 publication, 0.66%
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Universidade Estadual de Campinas
1 publication, 0.66%
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University of Texas at El Paso
1 publication, 0.66%
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University of Maribor
1 publication, 0.66%
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Universidad Complutense de Madrid
1 publication, 0.66%
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University of Calgary
1 publication, 0.66%
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University of Cádiz
1 publication, 0.66%
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Texas Tech University
1 publication, 0.66%
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AgroParisTech
1 publication, 0.66%
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CentraleSupélec
1 publication, 0.66%
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Université Paris-Saclay
1 publication, 0.66%
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University College Dublin
1 publication, 0.66%
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Heriot-Watt University
1 publication, 0.66%
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Show all (25 more) | |
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Publishing countries
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USA
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USA, 26, 17.11%
USA
26 publications, 17.11%
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India
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India, 19, 12.5%
India
19 publications, 12.5%
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Portugal
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Portugal, 16, 10.53%
Portugal
16 publications, 10.53%
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United Kingdom
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United Kingdom, 13, 8.55%
United Kingdom
13 publications, 8.55%
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Italy
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Italy, 13, 8.55%
Italy
13 publications, 8.55%
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Germany
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Germany, 10, 6.58%
Germany
10 publications, 6.58%
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France
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France, 8, 5.26%
France
8 publications, 5.26%
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China
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China, 8, 5.26%
China
8 publications, 5.26%
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Canada
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Canada, 8, 5.26%
Canada
8 publications, 5.26%
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Australia
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Australia, 7, 4.61%
Australia
7 publications, 4.61%
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Spain
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Spain, 7, 4.61%
Spain
7 publications, 4.61%
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Brazil
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Brazil, 5, 3.29%
Brazil
5 publications, 3.29%
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Greece
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Greece, 3, 1.97%
Greece
3 publications, 1.97%
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Mexico
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Mexico, 3, 1.97%
Mexico
3 publications, 1.97%
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Finland
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Finland, 3, 1.97%
Finland
3 publications, 1.97%
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Japan
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Japan, 3, 1.97%
Japan
3 publications, 1.97%
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Netherlands
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Netherlands, 2, 1.32%
Netherlands
2 publications, 1.32%
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Pakistan
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Pakistan, 2, 1.32%
Pakistan
2 publications, 1.32%
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Switzerland
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Switzerland, 2, 1.32%
Switzerland
2 publications, 1.32%
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Sweden
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Sweden, 2, 1.32%
Sweden
2 publications, 1.32%
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Russia
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Russia, 1, 0.66%
Russia
1 publication, 0.66%
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Ukraine
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Ukraine, 1, 0.66%
Ukraine
1 publication, 0.66%
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Argentina
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Argentina, 1, 0.66%
Argentina
1 publication, 0.66%
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Denmark
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Denmark, 1, 0.66%
Denmark
1 publication, 0.66%
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Egypt
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Egypt, 1, 0.66%
Egypt
1 publication, 0.66%
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Zambia
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Zambia, 1, 0.66%
Zambia
1 publication, 0.66%
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Israel
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Israel, 1, 0.66%
Israel
1 publication, 0.66%
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Iraq
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Iraq, 1, 0.66%
Iraq
1 publication, 0.66%
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Ireland
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Ireland, 1, 0.66%
Ireland
1 publication, 0.66%
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Qatar
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Qatar, 1, 0.66%
Qatar
1 publication, 0.66%
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Democratic Republic of the Congo
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Democratic Republic of the Congo, 1, 0.66%
Democratic Republic of the Congo
1 publication, 0.66%
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Nepal
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Nepal, 1, 0.66%
Nepal
1 publication, 0.66%
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Nigeria
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Nigeria, 1, 0.66%
Nigeria
1 publication, 0.66%
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Poland
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Poland, 1, 0.66%
Poland
1 publication, 0.66%
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Romania
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Romania, 1, 0.66%
Romania
1 publication, 0.66%
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Singapore
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Singapore, 1, 0.66%
Singapore
1 publication, 0.66%
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Slovenia
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Slovenia, 1, 0.66%
Slovenia
1 publication, 0.66%
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Philippines
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Philippines, 1, 0.66%
Philippines
1 publication, 0.66%
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Sri Lanka
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Sri Lanka, 1, 0.66%
Sri Lanka
1 publication, 0.66%
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South Africa
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South Africa, 1, 0.66%
South Africa
1 publication, 0.66%
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Show all (10 more) | |
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1 profile journal article
Marta Elena
🥼 🤝
146 publications,
2 039 citations
h-index: 23