Open Access

Pharmaceutics

, volume 13 , issue 12 , pages 1995

Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

Raphaëlle Youf ¹

Max Müller ²

Ali Balasini ³

Franck Thétiot ⁴

Mareike Müller ²

Alizé Hascoët ¹

U. Jonas ³

Holger Schönherr ²

G. Lemercier ⁵

T. Montier ^{1, 6}

Tony Le Gall ¹

Hide authors affiliations Show authors affiliations: 6 affiliations

Univ Brest, INSERM, EFS, UMR 1078, GGB-GTCA, F-29200 Brest, France

French Institute of Health and Medical Research

University of Western Brittany

Physical Chemistry I & Research Center of Micro- and Nanochemistry and (Bio)Technology of Micro and Nanochemistry and Engineering (Cμ), Department of Chemistry and Biology, University of Siegen, Adolf-Reichwein-Straße 2, 57076 Siegen, Germany |

Macromolecular Chemistry, Department of Chemistry and Biology, University of Siegen, Adolf-Reichwein-Straße 2, 57076 Siegen, Germany |

⁴

Unité Mixte de Recherche (UMR), Centre National de la Recherche Scientifique (CNRS) 6521, Université de Brest (UBO), CS 93837, 29238 Brest, France |

⁵

Coordination Chemistry Team, Unité Mixte de Recherche (UMR), Centre National de la Recherche Scientifique (CNRS) 7312, Institut de Chimie Moléculaire de Reims (ICMR), Université de Reims Champagne-Ardenne, BP 1039, CEDEX 2, 51687 Reims, France |

⁶

CHRU de Brest, Service de Génétique Médicale et de Biologie de la Reproduction, Centre de Référence des Maladies Rares Maladies Neuromusculaires, 29200 Brest, France |

Publication type: Journal Article

Publication date: 2021-11-24

MDPI

Pharmaceutics

scimago Q1

wos Q1

SJR: 1.075

CiteScore: 10.0

Impact factor: 5.5

ISSN: 19994923

DOI: 10.3390/pharmaceutics13121995

Copy DOI

PubMed ID: 34959277

Pharmaceutical Science

Abstract

Antimicrobial photodynamic therapy (aPDT) has become a fundamental tool in modern therapeutics, notably due to the expanding versatility of photosensitizers (PSs) and the numerous possibilities to combine aPDT with other antimicrobial treatments to combat localized infections. After revisiting the basic principles of aPDT, this review first highlights the current state of the art of curative or preventive aPDT applications with relevant clinical trials. In addition, the most recent developments in photochemistry and photophysics as well as advanced carrier systems in the context of aPDT are provided, with a focus on the latest generations of efficient and versatile PSs and the progress towards hybrid-multicomponent systems. In particular, deeper insight into combinatory aPDT approaches is afforded, involving non-radiative or other light-based modalities. Selected aPDT perspectives are outlined, pointing out new strategies to target and treat microorganisms. Finally, the review works out the evolution of the conceptually simple PDT methodology towards a much more sophisticated, integrated, and innovative technology as an important element of potent antimicrobial strategies.

Found

1 citation

Nikolskaya Elena

🤝

PhD in Chemistry

64 publications, 423 citations

h-index: 11

Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences

Research interests

Nanomaterials

Nanotechnology

Personalized medicine

Targeted drug delivery

1 citation

Gradov Oleg

🤝

152 publications, 254 citations, 8 reviews

h-index: 8

N.N. Semenov Federal Research Center for Chemical Physics of the Russian Academy of Sciences

1 citation

Antina Elena

DSc in Chemistry

207 publications, 2 282 citations

h-index: 22

G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences

1 citation

Bychkova Anna

🥼

PhD in Chemistry

62 publications, 509 citations

h-index: 14

Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences

Research interests

Biophysics

Colloidal chemistry

Electronic magnetic resonance

The structure of proteins

1 citation

Kuzmin Vladimir

393 publications, 2 927 citations

h-index: 27

Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences

1 citation

Eremeeva Yulia

11 publications, 42 citations

h-index: 4

G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences

Research interests

Absorption spectroscopy

Antimicrobial resistance

BODIPY

Luminescence

Top-30

Journals

	2 4 6 8 10
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 10, 7.69% International Journal of Molecular Sciences 10 publications, 7.69%
Pharmaceutics	Pharmaceutics, 9, 6.92% Pharmaceutics 9 publications, 6.92%
Photodiagnosis and Photodynamic Therapy	Photodiagnosis and Photodynamic Therapy, 7, 5.38% Photodiagnosis and Photodynamic Therapy 7 publications, 5.38%
Microorganisms	Microorganisms, 4, 3.08% Microorganisms 4 publications, 3.08%
Photochemical and Photobiological Sciences	Photochemical and Photobiological Sciences, 4, 3.08% Photochemical and Photobiological Sciences 4 publications, 3.08%
Molecules	Molecules, 3, 2.31% Molecules 3 publications, 2.31%
Photochemistry and Photobiology	Photochemistry and Photobiology, 3, 2.31% Photochemistry and Photobiology 3 publications, 2.31%
Antibiotics	Antibiotics, 2, 1.54% Antibiotics 2 publications, 1.54%
Scientific Reports	Scientific Reports, 2, 1.54% Scientific Reports 2 publications, 1.54%
International Journal of Pharmaceutics	International Journal of Pharmaceutics, 2, 1.54% International Journal of Pharmaceutics 2 publications, 1.54%
Journal of Dental Sciences	Journal of Dental Sciences, 2, 1.54% Journal of Dental Sciences 2 publications, 1.54%
Cureus	Cureus, 2, 1.54% Cureus 2 publications, 1.54%
ACS Applied Bio Materials	ACS Applied Bio Materials, 2, 1.54% ACS Applied Bio Materials 2 publications, 1.54%
Photonics	Photonics, 1, 0.77% Photonics 1 publication, 0.77%
Polymers	Polymers, 1, 0.77% Polymers 1 publication, 0.77%
Photochem	Photochem, 1, 0.77% Photochem 1 publication, 0.77%
BMC Research Notes	BMC Research Notes, 1, 0.77% BMC Research Notes 1 publication, 0.77%
Biofilm	Biofilm, 1, 0.77% Biofilm 1 publication, 0.77%
International Biodeterioration and Biodegradation	International Biodeterioration and Biodegradation, 1, 0.77% International Biodeterioration and Biodegradation 1 publication, 0.77%
Arabian Journal of Chemistry	Arabian Journal of Chemistry, 1, 0.77% Arabian Journal of Chemistry 1 publication, 0.77%
Frontiers in Microbiology	Frontiers in Microbiology, 1, 0.77% Frontiers in Microbiology 1 publication, 0.77%
Inorganic Chemistry	Inorganic Chemistry, 1, 0.77% Inorganic Chemistry 1 publication, 0.77%
ACS Applied Polymer Materials	ACS Applied Polymer Materials, 1, 0.77% ACS Applied Polymer Materials 1 publication, 0.77%
ACS Omega	ACS Omega, 1, 0.77% ACS Omega 1 publication, 0.77%
Pharmaceuticals	Pharmaceuticals, 1, 0.77% Pharmaceuticals 1 publication, 0.77%
Synthetic Metals	Synthetic Metals, 1, 0.77% Synthetic Metals 1 publication, 0.77%
Bioengineering	Bioengineering, 1, 0.77% Bioengineering 1 publication, 0.77%
European Polymer Journal	European Polymer Journal, 1, 0.77% European Polymer Journal 1 publication, 0.77%
Journal of the American Chemical Society	Journal of the American Chemical Society, 1, 0.77% Journal of the American Chemical Society 1 publication, 0.77%
	2 4 6 8 10

Publishers

	5 10 15 20 25 30 35 40
MDPI	MDPI, 38, 29.23% MDPI 38 publications, 29.23%
Elsevier	Elsevier, 33, 25.38% Elsevier 33 publications, 25.38%
Wiley	Wiley, 15, 11.54% Wiley 15 publications, 11.54%
Springer Nature	Springer Nature, 13, 10% Springer Nature 13 publications, 10%
American Chemical Society (ACS)	American Chemical Society (ACS), 9, 6.92% American Chemical Society (ACS) 9 publications, 6.92%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 6, 4.62% Royal Society of Chemistry (RSC) 6 publications, 4.62%
Frontiers Media S.A.	Frontiers Media S.A., 4, 3.08% Frontiers Media S.A. 4 publications, 3.08%
Taylor & Francis	Taylor & Francis, 2, 1.54% Taylor & Francis 2 publications, 1.54%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 2, 1.54% Cold Spring Harbor Laboratory 2 publications, 1.54%
King Saud University	King Saud University, 1, 0.77% King Saud University 1 publication, 0.77%
Institute of Electrical and Electronics Engineers (IEEE)	Institute of Electrical and Electronics Engineers (IEEE), 1, 0.77% Institute of Electrical and Electronics Engineers (IEEE) 1 publication, 0.77%
IntechOpen	IntechOpen, 1, 0.77% IntechOpen 1 publication, 0.77%
OOO Zhurnal "Mendeleevskie Soobshcheniya"	OOO Zhurnal "Mendeleevskie Soobshcheniya", 1, 0.77% OOO Zhurnal "Mendeleevskie Soobshcheniya" 1 publication, 0.77%
SPIE-Intl Soc Optical Eng	SPIE-Intl Soc Optical Eng, 1, 0.77% SPIE-Intl Soc Optical Eng 1 publication, 0.77%
Eco-Vector LLC	Eco-Vector LLC, 1, 0.77% Eco-Vector LLC 1 publication, 0.77%
World Scientific	World Scientific, 1, 0.77% World Scientific 1 publication, 0.77%
Medknow	Medknow, 1, 0.77% Medknow 1 publication, 0.77%
	5 10 15 20 25 30 35 40

We do not take into account publications without a DOI.
Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

PDF

Metrics

130

Cite this

GOST |

Cite this

GOST Copy

Youf R. et al. Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies // Pharmaceutics. 2021. Vol. 13. No. 12. p. 1995.

GOST all authors (up to 50) Copy

Youf R., Müller M., Balasini A., Thétiot F., Müller M., Hascoët A., Jonas U., Schönherr H., Lemercier G., Montier T., Le Gall T. Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies // Pharmaceutics. 2021. Vol. 13. No. 12. p. 1995.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.3390/pharmaceutics13121995

UR - https://doi.org/10.3390/pharmaceutics13121995

TI - Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

T2 - Pharmaceutics

AU - Youf, Raphaëlle

AU - Müller, Max

AU - Balasini, Ali

AU - Thétiot, Franck

AU - Müller, Mareike

AU - Hascoët, Alizé

AU - Jonas, U.

AU - Schönherr, Holger

AU - Lemercier, G.

AU - Montier, T.

AU - Le Gall, Tony

PY - 2021

DA - 2021/11/24

PB - MDPI

SP - 1995

IS - 12

VL - 13

PMID - 34959277

SN - 1999-4923

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2021_Youf,

author = {Raphaëlle Youf and Max Müller and Ali Balasini and Franck Thétiot and Mareike Müller and Alizé Hascoët and U. Jonas and Holger Schönherr and G. Lemercier and T. Montier and Tony Le Gall},

title = {Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies},

journal = {Pharmaceutics},

year = {2021},

volume = {13},

publisher = {MDPI},

month = {nov},

url = {https://doi.org/10.3390/pharmaceutics13121995},

number = {12},

pages = {1995},

doi = {10.3390/pharmaceutics13121995}

}

MLA

Cite this

MLA Copy

Youf, Raphaëlle, et al. “Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies.” Pharmaceutics, vol. 13, no. 12, Nov. 2021, p. 1995. https://doi.org/10.3390/pharmaceutics13121995.

Publisher

MDPI

Journal

Pharmaceutics

scimago Q1

wos Q1

SJR

1.075

CiteScore

10.0

Impact factor

5.5

ISSN

19994923 (Print, Electronic)