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Pharmaceutics, том 14, издание 3, номер публикации: 575

Development of Submicrocapsules Based on Co-Assembled Like-Charged Silica Nanoparticles and Detonation Nanodiamonds and Polyelectrolyte Layers

Palamarchuk Konstantin V. 1
Borodina Tatiana N. 2
Kostenko Anastasia V. 1, 3
Kamyshinsky Roman A. 1, 2, 3
Palamarchuk Natalya P. 1, 3
Yudina Elena B. 4
Тип документаJournal Article
Дата публикации2022-03-05
ИздательMultidisciplinary Digital Publishing Institute (MDPI)
Название журналаPharmaceutics
Квартиль по SCImagoQ1
Квартиль по Web of ScienceQ1
Импакт-фактор 20216.53
Pharmaceutical Science
Краткое описание

Capsules with shells based on nanoparticles of different nature co-assembled at the interface of liquid phases of emulsion are promising carriers of lipophilic drugs. To obtain such capsules, theoretically using the Derjaguin–Landau–Verwey–Overbeek (DLVO) theory and experimentally using dynamic light-scattering (DLS) and transmission electron microscopy (TEM) methods, the interaction of like-charged silica nanoparticles and detonation nanodiamonds in an aqueous solution was studied and their ratios selected for the formation of submicron-sized colloidosomes. The resulting colloidosomes were modified with additional layers of nanoparticles and polyelectrolytes, applying LbL technology. As a model anti-cancer drug, thymoquinone was loaded into the developed capsules, demonstrating a significant delay of the release as a result of colloidosome surface modification. Fluorescence flow cytometry and confocal laser scanning microscopy showed efficient internalization of the capsules by MCF7 cancer cells. The obtained results demonstrated a high potential for nanomedicine application in the field of the drug-delivery system development.

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1. Palamarchuk K. V. и др. Development of Submicrocapsules Based on Co-Assembled Like-Charged Silica Nanoparticles and Detonation Nanodiamonds and Polyelectrolyte Layers // Pharmaceutics. 2022. Т. 14. № 3. С. 575.


DO - 10.3390/pharmaceutics14030575

UR -

TI - Development of Submicrocapsules Based on Co-Assembled Like-Charged Silica Nanoparticles and Detonation Nanodiamonds and Polyelectrolyte Layers

T2 - Pharmaceutics

AU - Palamarchuk, Konstantin V.

AU - Borodina, Tatiana N.

AU - Kostenko, Anastasia V.

AU - Chesnokov, Yury M.

AU - Kamyshinsky, Roman A.

AU - Palamarchuk, Natalya P.

AU - Yudina, Elena B.

AU - Nikolskaya, Elena D.

AU - Yabbarov, Nikita G.

AU - Mollaeva, Mariia R.

AU - Bukreeva, Tatiana V.

PY - 2022

DA - 2022/03/05


SP - 575

IS - 3

VL - 14

SN - 1999-4923

ER -

BibTex |


doi = {10.3390/pharmaceutics14030575},

url = {},

year = 2022,

month = {mar},

publisher = {{MDPI} {AG}},

volume = {14},

number = {3},

pages = {575},

author = {Konstantin V. Palamarchuk and Tatiana N. Borodina and Anastasia V. Kostenko and Yury M. Chesnokov and Roman A. Kamyshinsky and Natalya P. Palamarchuk and Elena B. Yudina and Elena D. Nikolskaya and Nikita G. Yabbarov and Mariia R. Mollaeva and Tatiana V. Bukreeva},

title = {Development of Submicrocapsules Based on Co-Assembled Like-Charged Silica Nanoparticles and Detonation Nanodiamonds and Polyelectrolyte Layers},

journal = {Pharmaceutics}


Palamarchuk, Konstantin V., et al. “Development of Submicrocapsules Based on Co-Assembled Like-Charged Silica Nanoparticles and Detonation Nanodiamonds and Polyelectrolyte Layers.” Pharmaceutics, vol. 14, no. 3, Mar. 2022, p. 575. Crossref,