Open Access

eLife

, volume 9 , pages 1-32

Secondary ossification center induces and protects growth plate structure

Meng Xie ¹

Pavel Gol'din ²

Anna Nele Herdina ^{1, 3}

Jordi Estefa ⁴

Ekaterina V Medvedeva ⁵

Lei Li ¹

Phillip T Newton ^{1, 6}

Svetlana Kotova ^{5, 7}

Boris Shavkuta ⁵

Aditya Saxena ⁸

Lauren T Shumate ⁹

Brian Metscher ¹⁰

Karl Großschmidt ¹¹

Shigeki Nishimori ⁹

Anastasia Akovantseva ¹²

Anna P Usanova ⁵

Anastasiia D Kurenkova ⁵

Anoop Kumar ¹³

Irene Linares Arregui ¹⁴

Paul Tafforeau ¹⁵

Kaj Fried ¹⁶

Mattias Carlström ¹

András Simon ¹³

Christian Gasser ¹⁴

HENRY M. KRONENBERG ⁹

Murat Bastepe ⁹

Kimberly Cooper ⁸

Peter Timashev ^{5, 7, 12, 17}

Sophie Sanchez ^{4, 15, 18}

I. Adameyko ^{1, 19}

Anders Eriksson ²⁰

Andrei S. Chagin ^{1, 5}

Hide authors affiliations Show authors affiliations: 20 affiliations

Department of Physiology and Pharmacology, Karolinska Institutet, STOCKHOLM, Sweden |

Department of Evolutionary Morphology, Schmalhausen Institute of Zoology of NAS of Ukraine, Kiev, Ukraine |

Division of Anatomy, MIC, Medical University of Vienna, Vienna, Austria |

⁴

Science for Life Laboratory and Uppsala University, Subdepartment of Evolution and Development, Department of Organismal Biology, Uppsala, Sweden |

⁵

Institute for Regenerative Medicine, Sechenov University, Moscow, Russian Federation |

⁶

Department of Women’s and Children’s Health, Karolinska Institutet and Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Solna, Sweden

Karolinska Institute

Karolinska University Hospital

⁷

Semenov Institute of Chemical Physics, Moscow, Russian Federation |

⁸

Division of Biological Sciences, University of California San Diego, San Diego, United States |

⁹

Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, United States

Harvard University

Massachusetts General Hospital

¹⁰

Department of Theoretical Biology, University of Vienna, Vienna, Austria |

¹¹

Bone and Biomaterials Research, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria |

¹²

Institute of Photonic Technologies, Research center "Crystallography and Photonics", Moscow, Russian Federation

Kurchatov Complex of Crystallography and Photonics of NRC «Kurchatov Institute»

Institute of Photon Technologies

¹³

Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden |

¹⁴

Department of Solid Mechanics, KTH Royal Institute of Technology, Stockholm, Sweden |

¹⁵

European Synchrotron Radiation Facility, Grenoble, France |

¹⁶

Department of Neuroscience, Karolinska institutet, Stockholm, Sweden |

¹⁷

Chemistry Department, Lomonosov Moscow State University, Leninskiye Gory 1-3, Moscow, Russian Federation |

¹⁸

Sorbonne Université – CR2P – MNHN, CNRS, UPMC, Paris, France

Sorbonne University

Muséum national d'Histoire naturelle

¹⁹

Department of Neuroimmunology, Medical University of Vienna, Vienna, Austria |

²⁰

Department of Mechanics, KTH Royal Institute of Technology, Stockholm, Sweden |

Publication type: Journal Article

Publication date: 2020-10-01

eLife Sciences Publications

eLife

scimago Q1

SJR: 3.379

CiteScore: —

Impact factor: —

ISSN: 2050084X

DOI: 10.7554/eLife.55212

Copy DOI

PubMed ID: 33063669

General Biochemistry, Genetics and Molecular Biology

General Medicine

General Immunology and Microbiology

General Neuroscience

Abstract

Growth plate and articular cartilage constitute a single anatomical entity early in development but later separate into two distinct structures by the secondary ossification center (SOC). The reason for such separation remains unknown. We found that evolutionarily SOC appears in animals conquering the land - amniotes. Analysis of the ossification pattern in mammals with specialized extremities (whales, bats, jerboa) revealed that SOC development correlates with the extent of mechanical loads. Mathematical modeling revealed that SOC reduces mechanical stress within the growth plate. Functional experiments revealed the high vulnerability of hypertrophic chondrocytes to mechanical stress and showed that SOC protects these cells from apoptosis caused by extensive loading. Atomic force microscopy showed that hypertrophic chondrocytes are the least mechanically stiff cells within the growth plate. Altogether, these findings suggest that SOC has evolved to protect the hypertrophic chondrocytes from the high mechanical stress encountered in the terrestrial environment.

Found

1 citation

Kurenkova Anastasiia

PhD in Biological/biomedical sciences

12 publications, 161 citations

h-index: 5

Sechenov First Moscow State Medical University

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GOST Copy

Xie M. et al. Secondary ossification center induces and protects growth plate structure // eLife. 2020. Vol. 9. pp. 1-32.

GOST all authors (up to 50) Copy

Xie M., Gol'din P., Herdina A. N., Estefa J., Medvedeva E. V., Li L., Newton P. T., Kotova S., Shavkuta B., Saxena A., Shumate L. T., Metscher B., Großschmidt K., Nishimori S., Akovantseva A., Usanova A. P., Kurenkova A. D., Kumar A., Arregui I. L., Tafforeau P., Fried K., Carlström M., Simon A., Gasser C., KRONENBERG H. M., Bastepe M., Cooper K., Timashev P., Sanchez S., Adameyko I., Eriksson A., Chagin A. S. Secondary ossification center induces and protects growth plate structure // eLife. 2020. Vol. 9. pp. 1-32.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.7554/eLife.55212

UR - https://doi.org/10.7554/eLife.55212

TI - Secondary ossification center induces and protects growth plate structure

T2 - eLife

AU - Xie, Meng

AU - Gol'din, Pavel

AU - Herdina, Anna Nele

AU - Estefa, Jordi

AU - Medvedeva, Ekaterina V

AU - Li, Lei

AU - Newton, Phillip T

AU - Kotova, Svetlana

AU - Shavkuta, Boris

AU - Saxena, Aditya

AU - Shumate, Lauren T

AU - Metscher, Brian

AU - Großschmidt, Karl

AU - Nishimori, Shigeki

AU - Akovantseva, Anastasia

AU - Usanova, Anna P

AU - Kurenkova, Anastasiia D

AU - Kumar, Anoop

AU - Arregui, Irene Linares

AU - Tafforeau, Paul

AU - Fried, Kaj

AU - Carlström, Mattias

AU - Simon, András

AU - Gasser, Christian

AU - KRONENBERG, HENRY M.

AU - Bastepe, Murat

AU - Cooper, Kimberly

AU - Timashev, Peter

AU - Sanchez, Sophie

AU - Adameyko, I.

AU - Eriksson, Anders

AU - Chagin, Andrei S.

PY - 2020

DA - 2020/10/01

PB - eLife Sciences Publications

SP - 1-32

VL - 9

PMID - 33063669

SN - 2050-084X

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2020_Xie,

author = {Meng Xie and Pavel Gol'din and Anna Nele Herdina and Jordi Estefa and Ekaterina V Medvedeva and Lei Li and Phillip T Newton and Svetlana Kotova and Boris Shavkuta and Aditya Saxena and Lauren T Shumate and Brian Metscher and Karl Großschmidt and Shigeki Nishimori and Anastasia Akovantseva and Anna P Usanova and Anastasiia D Kurenkova and Anoop Kumar and Irene Linares Arregui and Paul Tafforeau and Kaj Fried and Mattias Carlström and András Simon and Christian Gasser and HENRY M. KRONENBERG and Murat Bastepe and Kimberly Cooper and Peter Timashev and Sophie Sanchez and I. Adameyko and Anders Eriksson and Andrei S. Chagin},

title = {Secondary ossification center induces and protects growth plate structure},

journal = {eLife},

year = {2020},

volume = {9},

publisher = {eLife Sciences Publications},

month = {oct},

url = {https://doi.org/10.7554/eLife.55212},

pages = {1--32},

doi = {10.7554/eLife.55212}

}

Publisher

eLife Sciences Publications

Journal

eLife

scimago Q1

SJR

3.379

CiteScore

—

Impact factor

—

ISSN

2050084X (Print, Electronic)

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