Open Access

Emerging Microbes and Infections, volume 10, issue 1, pages 1790-1806

Long-term humoral immunogenicity, safety and protective efficacy of inactivated vaccine against COVID-19 (CoviVac) in preclinical studies

Kozlovskaya Liubov I. ^{1, 2}

Piniaeva Anastasia N. ²

Ignatyev Georgy M. ²

Gordeychuk Ilya V. ^{1, 2}

Volok Viktor P. ^{2, 3}

Rogova Yulia V. ²

Shishova Anna A. ^{1, 2}

Kovpak Anastasia A. ²

Ivin Yury Yu. ²

Antonova Liliya P. ²

Mefyod Kirill M. ²

Prokosheva Lyubov S. ²

Sibirkina Anna S. ²

Tarasova Yuliya Yu. ²

Bayurova Ekaterina O. ²

Gancharova Olga S. ²

Illarionova Victoria V. ²

Glukhov Grigory S. ³

Sokolova Olga S. ³

Shaitan Konstantin V. ³

Moysenovich Anastasia M. ³

Gulyaev Stanislav A. ²

Gulyaeva Tatiana V. ²

Moroz Andrey V. ²

Gmyl Larissa V. ²

Ipatova Elena G. ²

Kirpichnikov Mikhail P. ³

Egorov Alexey M. ^{2, 3}

Siniugina Aleksandra A. ²

Ishmukhametov Aydar A. ^{1, 2}

Hide authors affiliations Show authors affiliations: 3 affiliations

Institute for Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, Moscow, Russia |

Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Moscow, Russia |

Department of Biology, Lomonosov Moscow State University, Moscow, Russia |

Publication type: Journal Article

Publication date: 2021-01-01

Springer Nature

Journal: Emerging Microbes and Infections

Quartile SCImago

Quartile WOS

Impact factor: 13.2

ISSN: 22221751

DOI: 10.1080/22221751.2021.1971569

Copy DOI

PubMed ID: 34427172

Drug Discovery

General Medicine

Microbiology

Infectious Diseases

Immunology

Epidemiology

Parasitology

Virology

Abstract

ABSTRACT The unprecedented in recent history global COVID-19 pandemic urged the implementation of all existing vaccine platforms to ensure the availability of the vaccines against COVID-19 to every country in the world. Despite the multitude of high-quality papers describing clinical trials of different vaccine products, basic detailed data on general toxicity, reproductive toxicity, immunogenicity, protective efficacy and durability of immune response in animal models are scarce. Here, we developed a β-propiolactone-inactivated whole virion vaccine CoviVac and assessed its safety, protective efficacy, immunogenicity and stability of the immune response in rodents and non-human primates. The vaccine showed no signs of acute/chronic, reproductive, embryo- and fetotoxicity, or teratogenic effects, as well as no allergenic properties in studied animal species. The vaccine induced stable and robust humoral immune response both in form of specific anti-SARS-CoV-2 IgG and NAbs in mice, Syrian hamsters, and common marmosets. The NAb levels did not decrease significantly over the course of one year. The course of two immunizations protected Syrian hamsters from severe pneumonia upon intranasal challenge with the live virus. Robustness of the vaccine manufacturing process was demonstrated as well. These data encouraged further evaluation of CoviVac in clinical trials.

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Citations by journals

	1 2 3 4 5
Viruses	Viruses, 5, 9.09% Viruses 5 publications, 9.09%
Vaccines	Vaccines, 4, 7.27% Vaccines 4 publications, 7.27%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 3, 5.45% International Journal of Molecular Sciences 3 publications, 5.45%
Epidemiology and Vaccinal Prevention (Epidemiologiya i Vaktsinoprofilaktika)	Epidemiology and Vaccinal Prevention (Epidemiologiya i Vaktsinoprofilaktika), 2, 3.64% Epidemiology and Vaccinal Prevention (Epidemiologiya i Vaktsinoprofilaktika) 2 publications, 3.64%
Medical academic journal	Medical academic journal, 2, 3.64% Medical academic journal 2 publications, 3.64%
Microscopy Research and Technique	Microscopy Research and Technique, 1, 1.82% Microscopy Research and Technique 1 publication, 1.82%
Journal of microbiology epidemiology immunobiology	Journal of microbiology epidemiology immunobiology, 1, 1.82% Journal of microbiology epidemiology immunobiology 1 publication, 1.82%
Immunotherapy	Immunotherapy, 1, 1.82% Immunotherapy 1 publication, 1.82%
Toxicologic Pathology	Toxicologic Pathology, 1, 1.82% Toxicologic Pathology 1 publication, 1.82%
International Journal of Environmental Research and Public Health	International Journal of Environmental Research and Public Health, 1, 1.82% International Journal of Environmental Research and Public Health 1 publication, 1.82%
Frontiers in Drug Discovery	Frontiers in Drug Discovery, 1, 1.82% Frontiers in Drug Discovery 1 publication, 1.82%
Frontiers in Materials	Frontiers in Materials, 1, 1.82% Frontiers in Materials 1 publication, 1.82%
Pharmaceutics	Pharmaceutics, 1, 1.82% Pharmaceutics 1 publication, 1.82%
COVID	COVID, 1, 1.82% COVID 1 publication, 1.82%
Pathogens	Pathogens, 1, 1.82% Pathogens 1 publication, 1.82%
Cellular and Molecular Biology Letters	Cellular and Molecular Biology Letters, 1, 1.82% Cellular and Molecular Biology Letters 1 publication, 1.82%
Archives of Virology	Archives of Virology, 1, 1.82% Archives of Virology 1 publication, 1.82%
BMC Public Health	BMC Public Health, 1, 1.82% BMC Public Health 1 publication, 1.82%
Respiratory Research	Respiratory Research, 1, 1.82% Respiratory Research 1 publication, 1.82%
Infection, Genetics and Evolution	Infection, Genetics and Evolution, 1, 1.82% Infection, Genetics and Evolution 1 publication, 1.82%
Vaccine	Vaccine, 1, 1.82% Vaccine 1 publication, 1.82%
Journal of Drug Delivery Science and Technology	Journal of Drug Delivery Science and Technology, 1, 1.82% Journal of Drug Delivery Science and Technology 1 publication, 1.82%
Journal of Controlled Release	Journal of Controlled Release, 1, 1.82% Journal of Controlled Release 1 publication, 1.82%
iScience	iScience, 1, 1.82% iScience 1 publication, 1.82%
Molecular Biology	Molecular Biology, 1, 1.82% Molecular Biology 1 publication, 1.82%
Health Science Reports	Health Science Reports, 1, 1.82% Health Science Reports 1 publication, 1.82%
Herald of the Russian Academy of Sciences	Herald of the Russian Academy of Sciences, 1, 1.82% Herald of the Russian Academy of Sciences 1 publication, 1.82%
Acta Naturae	Acta Naturae, 1, 1.82% Acta Naturae 1 publication, 1.82%
Cardiovascular Therapy and Prevention (Russian Federation)	Cardiovascular Therapy and Prevention (Russian Federation), 1, 1.82% Cardiovascular Therapy and Prevention (Russian Federation) 1 publication, 1.82%
	1 2 3 4 5

Citations by publishers

	2 4 6 8 10 12 14 16
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 16, 29.09% Multidisciplinary Digital Publishing Institute (MDPI) 16 publications, 29.09%
Elsevier	Elsevier, 6, 10.91% Elsevier 6 publications, 10.91%
Springer Nature	Springer Nature, 5, 9.09% Springer Nature 5 publications, 9.09%
Wiley	Wiley, 4, 7.27% Wiley 4 publications, 7.27%
Frontiers Media S.A.	Frontiers Media S.A., 2, 3.64% Frontiers Media S.A. 2 publications, 3.64%
Pleiades Publishing	Pleiades Publishing, 2, 3.64% Pleiades Publishing 2 publications, 3.64%
National Association of the Specialists in Control of Health Care-Associated Infections	National Association of the Specialists in Control of Health Care-Associated Infections, 2, 3.64% National Association of the Specialists in Control of Health Care-Associated Infections 2 publications, 3.64%
Eco-Vector LLC	Eco-Vector LLC, 2, 3.64% Eco-Vector LLC 2 publications, 3.64%
Central Research Institute for Epidemiology	Central Research Institute for Epidemiology, 1, 1.82% Central Research Institute for Epidemiology 1 publication, 1.82%
Future Medicine	Future Medicine, 1, 1.82% Future Medicine 1 publication, 1.82%
SAGE	SAGE, 1, 1.82% SAGE 1 publication, 1.82%
Acta Naturae Ltd	Acta Naturae Ltd, 1, 1.82% Acta Naturae Ltd 1 publication, 1.82%
Russian Society of Cardiology	Russian Society of Cardiology, 1, 1.82% Russian Society of Cardiology 1 publication, 1.82%
Scientific Center for Expert Evaluation of Medicinal Products (SCEEMP)	Scientific Center for Expert Evaluation of Medicinal Products (SCEEMP), 1, 1.82% Scientific Center for Expert Evaluation of Medicinal Products (SCEEMP) 1 publication, 1.82%
Saint Petersburg Pasteur Institute	Saint Petersburg Pasteur Institute, 1, 1.82% Saint Petersburg Pasteur Institute 1 publication, 1.82%
Alfmed LLC	Alfmed LLC, 1, 1.82% Alfmed LLC 1 publication, 1.82%
Sovero Press Publishing House	Sovero Press Publishing House, 1, 1.82% Sovero Press Publishing House 1 publication, 1.82%
National Library of Serbia	National Library of Serbia, 1, 1.82% National Library of Serbia 1 publication, 1.82%
Reaviz Medical University	Reaviz Medical University, 1, 1.82% Reaviz Medical University 1 publication, 1.82%
	2 4 6 8 10 12 14 16

We do not take into account publications that without a DOI.
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Kozlovskaya L. I. et al. Long-term humoral immunogenicity, safety and protective efficacy of inactivated vaccine against COVID-19 (CoviVac) in preclinical studies // Emerging Microbes and Infections. 2021. Vol. 10. No. 1. pp. 1790-1806.

GOST all authors (up to 50) Copy

Kozlovskaya L. I., Piniaeva A. N., Ignatyev G. M., Gordeychuk I. V., Volok V. P., Rogova Y. V., Shishova A. A., Kovpak A. A., Ivin Y. Y., Antonova L. P., Mefyod K. M., Prokosheva L. S., Sibirkina A. S., Tarasova Y. Y., Bayurova E. O., Gancharova O. S., Illarionova V. V., Glukhov G. S., Sokolova O. S., Shaitan K. V., Moysenovich A. M., Gulyaev S. A., Gulyaeva T. V., Moroz A. V., Gmyl L. V., Ipatova E. G., Kirpichnikov M. P., Egorov A. M., Siniugina A. A., Ishmukhametov A. A. Long-term humoral immunogenicity, safety and protective efficacy of inactivated vaccine against COVID-19 (CoviVac) in preclinical studies // Emerging Microbes and Infections. 2021. Vol. 10. No. 1. pp. 1790-1806.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1080/22221751.2021.1971569

UR - https://doi.org/10.1080%2F22221751.2021.1971569

TI - Long-term humoral immunogenicity, safety and protective efficacy of inactivated vaccine against COVID-19 (CoviVac) in preclinical studies

T2 - Emerging Microbes and Infections

AU - Kozlovskaya, Liubov I.

AU - Piniaeva, Anastasia N.

AU - Ignatyev, Georgy M.

AU - Gordeychuk, Ilya V.

AU - Volok, Viktor P.

AU - Rogova, Yulia V.

AU - Shishova, Anna A.

AU - Kovpak, Anastasia A.

AU - Ivin, Yury Yu.

AU - Antonova, Liliya P.

AU - Mefyod, Kirill M.

AU - Prokosheva, Lyubov S.

AU - Sibirkina, Anna S.

AU - Tarasova, Yuliya Yu.

AU - Bayurova, Ekaterina O.

AU - Gancharova, Olga S.

AU - Illarionova, Victoria V.

AU - Glukhov, Grigory S.

AU - Sokolova, Olga S.

AU - Shaitan, Konstantin V.

AU - Moysenovich, Anastasia M.

AU - Gulyaev, Stanislav A.

AU - Gulyaeva, Tatiana V.

AU - Moroz, Andrey V.

AU - Gmyl, Larissa V.

AU - Ipatova, Elena G.

AU - Kirpichnikov, Mikhail P.

AU - Egorov, Alexey M.

AU - Siniugina, Aleksandra A.

AU - Ishmukhametov, Aydar A.

PY - 2021

DA - 2021/01/01 00:00:00

PB - Springer Nature

SP - 1790-1806

IS - 1

VL - 10

PMID - 34427172

SN - 2222-1751

ER -

BibTex |

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BibTex Copy

@article{2021_Kozlovskaya,

author = {Liubov I. Kozlovskaya and Anastasia N. Piniaeva and Georgy M. Ignatyev and Ilya V. Gordeychuk and Viktor P. Volok and Yulia V. Rogova and Anna A. Shishova and Anastasia A. Kovpak and Yury Yu. Ivin and Liliya P. Antonova and Kirill M. Mefyod and Lyubov S. Prokosheva and Anna S. Sibirkina and Yuliya Yu. Tarasova and Ekaterina O. Bayurova and Olga S. Gancharova and Victoria V. Illarionova and Grigory S. Glukhov and Olga S. Sokolova and Konstantin V. Shaitan and Anastasia M. Moysenovich and Stanislav A. Gulyaev and Tatiana V. Gulyaeva and Andrey V. Moroz and Larissa V. Gmyl and Elena G. Ipatova and Mikhail P. Kirpichnikov and Alexey M. Egorov and Aleksandra A. Siniugina and Aydar A. Ishmukhametov},

title = {Long-term humoral immunogenicity, safety and protective efficacy of inactivated vaccine against COVID-19 (CoviVac) in preclinical studies},

journal = {Emerging Microbes and Infections},

year = {2021},

volume = {10},

publisher = {Springer Nature},

month = {jan},

url = {https://doi.org/10.1080%2F22221751.2021.1971569},

number = {1},

pages = {1790--1806},

doi = {10.1080/22221751.2021.1971569}

}

MLA

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MLA Copy

Kozlovskaya, Liubov I., et al. “Long-term humoral immunogenicity, safety and protective efficacy of inactivated vaccine against COVID-19 (CoviVac) in preclinical studies.” Emerging Microbes and Infections, vol. 10, no. 1, Jan. 2021, pp. 1790-1806. https://doi.org/10.1080%2F22221751.2021.1971569.

Found error?

Publisher

Springer Nature

Journal

Emerging Microbes and Infections

Quartile SCImago

Quartile WOS

Impact factor

13.2

ISSN

22221751 (Print)

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