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An effective one-pot access to polynuclear dispiroheterocyclic structures comprising pyrrolidinyloxindole and imidazothiazolotriazine moieties via a 1,3-dipolar cycloaddition strategy

Izmest’ev A.N., Gazieva G.A., Sigay N.V., Serkov S.A., Karnoukhova V.A., Kachala V.V., Shashkov A.S., Zanin I.E., Kravchenko A.N., Makhova N.N.
Тип документаJournal Article
Дата публикации2016-10-24
Название журналаBeilstein Journal of Organic Chemistry
ИздательBeilstein-Institut
КвартильQ2
ISSN18605397
  • Organic Chemistry
Краткое описание

An effective and highly regio- and diastereoselective one-pot method for the synthesis of new polynuclear dispiroheterocyclic systems with five stereogenic centers (dispiro[imidazo[4,5-e]thiazolo[3,2-b]-1,2,4-triazine-6,3′-pyrrolidine-2′,3′′-indoles]) comprising pyrrolidinyloxindole and imidazo[4,5-e]thiazolo[3,2-b]-1,2,4-triazine moieties has been developed. The method relies on a 1,3-dipolar cycloaddition of azomethine ylides generated in situ from isatin derivatives and sarcosine to 6-benzylideneimidazo[4,5-e]thiazolo[3,2-b]-1,2,4-triazine-2,7-diones.

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1. Izmest’ev A.N. и др. An effective one-pot access to polynuclear dispiroheterocyclic structures comprising pyrrolidinyloxindole and imidazothiazolotriazine moieties via a 1,3-dipolar cycloaddition strategy // Beilstein Journal of Organic Chemistry. 2016. Т. 12. С. 2240–2249.
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TY - JOUR

DO - 10.3762/bjoc.12.216

UR - http://dx.doi.org/10.3762/bjoc.12.216

TI - An effective one-pot access to polynuclear dispiroheterocyclic structures comprising pyrrolidinyloxindole and imidazothiazolotriazine moieties via a 1,3-dipolar cycloaddition strategy

T2 - Beilstein Journal of Organic Chemistry

AU - Izmest’ev, Alexei N

AU - Gazieva, Galina A

AU - Sigay, Natalya V

AU - Serkov, Sergei A

AU - Karnoukhova, Valentina A

AU - Kachala, Vadim V

AU - Shashkov, Alexander S

AU - Zanin, Igor E

AU - Kravchenko, Angelina N

AU - Makhova, Nina N

PY - 2016

DA - 2016/10/24

PB - Beilstein Institut

SP - 2240-2249

VL - 12

SN - 1860-5397

ER -

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@article{2016,

doi = {10.3762/bjoc.12.216},

url = {https://doi.org/10.3762%2Fbjoc.12.216},

year = 2016,

month = {oct},

publisher = {Beilstein Institut},

volume = {12},

pages = {2240--2249},

author = {Alexei N Izmest'ev and Galina A Gazieva and Natalya V Sigay and Sergei A Serkov and Valentina A Karnoukhova and Vadim V Kachala and Alexander S Shashkov and Igor E Zanin and Angelina N Kravchenko and Nina N Makhova},

title = {An effective one-pot access to polynuclear dispiroheterocyclic structures comprising pyrrolidinyloxindole and imidazothiazolotriazine moieties via a 1,3-dipolar cycloaddition strategy}

}

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Izmest’ev, Alexei N et al. “An Effective One-Pot Access to Polynuclear Dispiroheterocyclic Structures Comprising Pyrrolidinyloxindole and Imidazothiazolotriazine Moieties via a 1,3-Dipolar Cycloaddition Strategy.” Beilstein Journal of Organic Chemistry 12 (2016): 2240–2249. Crossref. Web.