Journal of Shanghai Jiaotong University (Science)

MicroRNA (miRNA)-processing machinery may modify the risk of primary Sjögren's syndrome (pSS) by altering miRNA expression profiles. Inflammatory cytokines and reactive oxygen species (ROS) are also involved in pSS; however, the role of altered miRNAs expression in its pathogenesis is still unclear. We aimed to evaluate the relationship between single-nucleotide polymorphisms (SNPs) in miRNA processing machinery genes, including XPO5 (rs11077), RAN (rs14035), Dicer (rs3742330), TNRC6B (rs9623117), GEMIN3 (rs197412), and GEMIN4 (rs2740348), and the risk of pSS in female patients. The potential associations of cytokines and ROS with pSS-susceptible SNPs were also evaluated.

A 36-year-old man presented to a respiratory medicine clinic for evaluation of a cough and yellow, purulent sputum for > 20 years. The cough had worsened since asthma was diagnosed 3 months prior. He had a history of chronic sinusitis. The physical examination showed that the heart was within the right thorax. A chest radiograph showed increased lung texture with multiple cystic translucencies in both lungs (Figure 1, white arrow) and transposition of the heart (Panel A, blue arrow). Computed tomography (CT) of the chest revealed bronchiectasis (Panel B, white arrow) and a right-sided heart (Panel B, blue arrow). An abdominal color ultrasound showed that the liver was situated on the left and the spleen was situated on the right. In addition, CT of the head showed mucosal thickening (Panel C, white arrow) and a low-density shadow filling the paranasal sinuses (Panel C, blue arrow). Kartagener's syndrome is a hereditary disease with the following typical symptoms: situs inversus; bronchiectasis; and chronic infections of the nasal mucosa. Bronchiectasis and recurrent lung infections can develop into end-stage lung diseases. The patient underwent a double lung transplant and was discharged in stable condition 1 month postoperatively. The patient was doing well at the 5-year follow-up evaluation. Panel D shows the most recent chest CT scan.

Whether Astragalus membranaceus is an effective drug in treatment of ulcerative colitis (UC) and how it exhibit activity effect on UC is unclear.

To explore the ideas and research progress in diagnosing and treating hypercalcemic crisis in patients with cancer.