Laboratory of Genetic and Environmental Determinants of the Human Life Cycle

1. To study the prevalence of abdominal obesity in people aged 35-74 years in the Novosibirsk region (urban and rural residents). 2. To study the prevalence of therapeutic diseases and risk factors (coronary heart disease, hypertension, hyperHC, hyperHC-LDL, type 2 diabetes) in people with abdominal obesity in comparison with people without abdominal obesity. 3. To study blood levels of adipokines in people with common therapeutic diseases on the background of abdominal obesity and without it. 4. To study the nutritional characteristics of the examined individuals, including their associations with the presence of risk factors and with the level of blood adipokines. 5. To search for associations of blood levels of adipokines with the presence of common therapeutic diseases against the background of abdominal obesity in young people. 6. To search for associations of risk factors in people aged 35-74 with the development of cardiovascular diseases and type 2 diabetes mellitus in the long-term 5-year period. 7. To search for associations of blood levels of adipokines in people 35-74 years old with abdominal obesity with the development of cardiovascular diseases, diabetes mellitus in the long-term 5-year period. 8. To develop a clinical and biochemical riskometer to assess the risk of developing cardiovascular diseases and diabetes mellitus in people aged 35-74 years in the long-term 5-year period.

The purpose of the work: To study the clinical, laboratory and genetic aspects of the phenotypes of postcovid syndrome. Research objectives 1. To study the clinical features of the formation of postcovid syndrome phenotypes in patients who have undergone COVID-19. 2. To study the laboratory parameters of various phenotypes of postcovid syndrome in patients who have undergone COVID-19. 3. To establish associations of clinical and laboratory parameters with various phenotypes of postcovid syndrome. 4. To study the genetic aspects of various phenotypes of postcovid syndrome in patients who have undergone COVID-19.

To study the associations of the severity of postcovid syndrome (long covid) with the presence of obesity, including abdominal obesity, and with adipocytokines and metabolic hormones in COVID-19 convalescents. Research objectives 1. To determine the criteria and signs of different degrees of severity of postcovid syndrome in COVID-19 convalescents. 2. To study the associations of severity of postcovid syndrome with the presence of obesity, including abdominal, as well as other metabolic disorders, including lipid, in COVID-19 convalescents. 3. To study the associations of severity of postcovid syndrome with blood levels of adipokines and metabolic hormones in COVID-19 convalescents to clarify and complement the etiopathogenesis of postcovid syndrome.