Open Access
Molecular Medicine, volume 26, issue 1, publication number 51
Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases
Pravednikova Anna E
1, 2
,
Shevchenko Sergey Y
1
,
Kerchev Victor V
2
,
Skhirtladze Manana R
2
,
Larina Svetlana N
2
,
Kachaev Zaur M.
1
,
Shidlovskii Y. V.
1, 2
Publication type: Journal Article
Publication date: 2020-05-25
Journal:
Molecular Medicine
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.7
ISSN: 10761551, 15283658
PubMed ID:
32450815
Molecular Biology
Genetics
Molecular Medicine
Genetics (clinical)
Abstract
The hereditary aspect of obesity is a major focus of modern medical genetics. The genetic background is known to determine a higher-than-average prevalence of obesity in certain regions, like Oceania. There is evidence that dysfunction of brown adipose tissue (BAT) may be a risk factor for obesity and type 2 diabetes (T2D). A significant number of studies in the field focus on the UCP family. The Ucp genes code for electron transport carriers. UCP1 (thermogenin) is the most abundant protein of the UCP superfamily and is expressed in BAT, contributing to its capability of generating heat. Single nucleotide polymorphisms (SNPs) of Ucp1–Ucp3 were recently associated with risk of cardiometabolic diseases. This review covers the main Ucp SNPs A–3826G, A–1766G, A–112C, Met229Leu, Ala64Thr (Ucp1), Ala55Val, G–866A (Ucp2), and C–55 T (Ucp3), which may be associated with the development of obesity, disturbance in lipid metabolism, T2D, and cardiovascular diseases.
Citations by journals
|
1
|
|
|
Moscow University Biological Sciences Bulletin
|
Moscow University Biological Sciences Bulletin
1 publication, 5.26%
|
|
PLoS ONE
|
PLoS ONE
1 publication, 5.26%
|
|
Scientific Reports
|
Scientific Reports
1 publication, 5.26%
|
|
Chemosphere
|
Chemosphere
1 publication, 5.26%
|
|
Biochemical Pharmacology
|
Biochemical Pharmacology
1 publication, 5.26%
|
|
Environmental Pollution
|
Environmental Pollution
1 publication, 5.26%
|
|
Diabetes Research and Clinical Practice
|
Diabetes Research and Clinical Practice
1 publication, 5.26%
|
|
Obesity Science and Practice
|
Obesity Science and Practice
1 publication, 5.26%
|
|
International Journal of Hyperthermia
|
International Journal of Hyperthermia
1 publication, 5.26%
|
|
BioMed Research International
|
BioMed Research International
1 publication, 5.26%
|
|
Plants
|
Plants
1 publication, 5.26%
|
|
Vestnik Archeologii, Antropologii i Etnografii
|
Vestnik Archeologii, Antropologii i Etnografii
1 publication, 5.26%
|
|
Philosophical Transactions of the Royal Society B: Biological Sciences
|
Philosophical Transactions of the Royal Society B: Biological Sciences
1 publication, 5.26%
|
|
Nature
|
Nature
1 publication, 5.26%
|
|
Biochimie
|
Biochimie
1 publication, 5.26%
|
|
Journal of Ethnopharmacology
|
Journal of Ethnopharmacology
1 publication, 5.26%
|
|
1
|
Citations by publishers
|
1
2
3
4
5
6
|
|
|
Elsevier
|
Elsevier
6 publications, 31.58%
|
|
Springer Nature
|
Springer Nature
2 publications, 10.53%
|
|
Pleiades Publishing
|
Pleiades Publishing
1 publication, 5.26%
|
|
Public Library of Science (PLoS)
|
Public Library of Science (PLoS)
1 publication, 5.26%
|
|
Wiley
|
Wiley
1 publication, 5.26%
|
|
Taylor & Francis
|
Taylor & Francis
1 publication, 5.26%
|
|
Hindawi Limited
|
Hindawi Limited
1 publication, 5.26%
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 5.26%
|
|
Tyumen Scientific Center of the SB RAS
|
Tyumen Scientific Center of the SB RAS
1 publication, 5.26%
|
|
The Royal Society
|
The Royal Society
1 publication, 5.26%
|
|
1
2
3
4
5
6
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2021,2022,2023,2024],"ids":[0,0,0,0],"codes":[0,0,0,0],"imageUrls":["","","",""],"datasets":[{"label":"Citations number","data":[8,3,6,2],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["42.11","15.79","31.58","10.53"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Moscow University Biological Sciences Bulletin","PLoS ONE","Scientific Reports","Chemosphere","Biochemical Pharmacology","Environmental Pollution","Diabetes Research and Clinical Practice","Obesity Science and Practice","International Journal of Hyperthermia","BioMed Research International","Plants","Vestnik Archeologii, Antropologii i Etnografii","Philosophical Transactions of the Royal Society B: Biological Sciences","Nature","Biochimie","Journal of Ethnopharmacology"],"ids":[12722,24963,13767,22418,20448,13439,7600,21616,10351,8750,17251,24301,4020,14611,4794,13298],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/hqfzhQAjTGlNSRs6yzFNITgjSMm9Jr2QuotJHIvE_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/ZBUMg4H437EJp4gzpvY3U1kqJ6RFXGX4YO2wbYwb_medium.webp","\/storage\/images\/resized\/BHBStD1OkQqtKFRRjS5njgNe7bXCAEgaDQVK7GTA_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp"],"datasets":[{"label":"","data":[1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[5.26,5.26,5.26,5.26,5.26,5.26,5.26,5.26,5.26,5.26,5.26,5.26,5.26,5.26,5.26,5.26],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Elsevier","Springer Nature","Pleiades Publishing","Public Library of Science (PLoS)","Wiley","Taylor & Francis","Hindawi Limited","Multidisciplinary Digital Publishing Institute (MDPI)","Tyumen Scientific Center of the SB RAS","The Royal Society"],"ids":[17,8,101,344,11,18,6921,202,6664,259],"codes":[0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/PRGhlgB4OKRltSNtT39eA6wlnOTGRap1QQ6FQHih_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/hqfzhQAjTGlNSRs6yzFNITgjSMm9Jr2QuotJHIvE_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/ZBUMg4H437EJp4gzpvY3U1kqJ6RFXGX4YO2wbYwb_medium.webp","\/storage\/images\/resized\/BHBStD1OkQqtKFRRjS5njgNe7bXCAEgaDQVK7GTA_medium.webp"],"datasets":[{"label":"","data":[6,2,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[31.58,10.53,5.26,5.26,5.26,5.26,5.26,5.26,5.26,5.26],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex
Cite this
GOST
Copy
Pravednikova A. E. et al. Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases // Molecular Medicine. 2020. Vol. 26. No. 1. 51
GOST all authors (up to 50)
Copy
Pravednikova A. E., Shevchenko S. Y., Kerchev V. V., Skhirtladze M. R., Larina S. N., Kachaev Z. M., Egorov A. D., Shidlovskii Y. V. Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases // Molecular Medicine. 2020. Vol. 26. No. 1. 51
Cite this
RIS
Copy
TY - JOUR
DO - 10.1186/s10020-020-00180-4
UR - https://doi.org/10.1186%2Fs10020-020-00180-4
TI - Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases
T2 - Molecular Medicine
AU - Shevchenko, Sergey Y
AU - Kerchev, Victor V
AU - Skhirtladze, Manana R
AU - Larina, Svetlana N
AU - Egorov, Alexander D
AU - Shidlovskii, Y. V.
AU - Pravednikova, Anna E
AU - Kachaev, Zaur M.
PY - 2020
DA - 2020/05/25 00:00:00
PB - Feinstein Institute for Medical Research
IS - 1
VL - 26
PMID - 32450815
SN - 1076-1551
SN - 1528-3658
ER -
Cite this
BibTex
Copy
@article{2020_Pravednikova,
author = {Sergey Y Shevchenko and Victor V Kerchev and Manana R Skhirtladze and Svetlana N Larina and Alexander D Egorov and Y. V. Shidlovskii and Anna E Pravednikova and Zaur M. Kachaev},
title = {Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases},
journal = {Molecular Medicine},
year = {2020},
volume = {26},
publisher = {Feinstein Institute for Medical Research},
month = {may},
url = {https://doi.org/10.1186%2Fs10020-020-00180-4},
number = {1},
doi = {10.1186/s10020-020-00180-4}
}